ID A0A7P0TB80_HUMAN Unreviewed; 422 AA. AC A0A7P0TB80; DT 02-JUN-2021, integrated into UniProtKB/TrEMBL. DT 02-JUN-2021, sequence version 1. DT 14-DEC-2022, entry version 6. DE SubName: Full=Vacuolar protein sorting-associated protein 53 homolog {ECO:0000313|Ensembl:ENSP00000506475.1}; GN Name=VPS53 {ECO:0000313|Ensembl:ENSP00000506475.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000506475.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000506475.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the RT human lineage."; RL Nature 440:1045-1049(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000506475.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2022) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Endosome membrane CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004150}. Membrane CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004170}. CC -!- SIMILARITY: Belongs to the VPS53 family. CC {ECO:0000256|ARBA:ARBA00008628}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC015853; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC027455; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877627; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877635; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; A0A7P0TB80; -. DR SMR; A0A7P0TB80; -. DR PeptideAtlas; A0A7P0TB80; -. DR Ensembl; ENST00000681133.1; ENSP00000506475.1; ENSG00000141252.21. DR HGNC; HGNC:25608; VPS53. DR GeneTree; ENSGT00390000015165; -. DR Proteomes; UP000005640; Chromosome 17. DR Bgee; ENSG00000141252; Expressed in sural nerve and 105 other tissues. DR GO; GO:0005829; C:cytosol; IEA:GOC. DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0000938; C:GARP complex; IEA:InterPro. DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro. DR InterPro; IPR039766; Vps53. DR InterPro; IPR007234; Vps53_N. DR PANTHER; PTHR12820; VACUOLAR SORTING PROTEIN 53; 1. DR Pfam; PF04100; Vps53_N; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Endosome {ECO:0000256|ARBA:ARBA00022753}; KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Proteomics identification {ECO:0007829|EPD:A0A7P0TB80, KW ECO:0007829|MaxQB:A0A7P0TB80}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 41..400 FT /note="Vps53_N" FT /evidence="ECO:0000259|Pfam:PF04100" FT REGION 373..392 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 97..138 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 422 AA; 48550 MW; 2A0CB3BE2F7EF46F CRC64; MMEEEELEFV EELEAVLQLT PEVQLAIEQV FPSQDPLDRA DFNAVEYINT LFPTEQSLAN IDEVVNKIRL KIRRLDDNIR TVVRGQTNVG QDGRQALEEA QKAIQQLFGK IKDIKDKAEK SEQMVKEITR DIKQLDHAKR HLTTSITTLN HLHMLAGGVD SLEAMTRRRQ YGEVANLLQG VMNVLEHFHK YMGIPQIRQL SERVKAAQTE LGQQILADFE EAFPSQGTKR PGGPSNVLRD ACLVANILDP RIKQEIIKKF IKQHLSEYLV LFQENQDVAW LDKIDRRYAW IKRQLVDYEE KYGRMFPREW CMAERIAVEF CHVTRAELAK IMRTRAKEIE VKLLLFAIQR TTNFEGFLAK RFSGCTLTDG TLKKLESPPP STNPFLEDEP TPEMEELATE KGDLDQVSLV CVTTGNLPNV RF //