ID A0A7N4PTY6_SARHA Unreviewed; 442 AA. AC A0A7N4PTY6; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 03-AUG-2022, entry version 4. DE RecName: Full=Annexin {ECO:0000256|RuleBase:RU003540}; GN Name=ANXA2 {ECO:0000313|Ensembl:ENSSHAP00000043545}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000043545, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000043545, ECO:0000313|Proteomes:UP000007648} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J., RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C., RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P., RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M., RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M., RA Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered marsupial RT Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000043545} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2021) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}. CC Secreted, extracellular space, extracellular matrix, basement membrane CC {ECO:0000256|ARBA:ARBA00004302}. CC -!- DOMAIN: A pair of annexin repeats may form one binding site for calcium CC and phospholipid. {ECO:0000256|RuleBase:RU003540}. CC -!- SIMILARITY: Belongs to the annexin family. CC {ECO:0000256|ARBA:ARBA00007831, ECO:0000256|RuleBase:RU003540}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSSHAT00000032872.1; ENSSHAP00000043545.1; ENSSHAG00000015232.2. DR GeneTree; ENSGT00940000154257; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW. DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro. DR GO; GO:0004859; F:phospholipase inhibitor activity; IEA:InterPro. DR Gene3D; 1.10.220.10; -; 4. DR InterPro; IPR001464; Annexin. DR InterPro; IPR018502; Annexin_repeat. DR InterPro; IPR018252; Annexin_repeat_CS. DR InterPro; IPR037104; Annexin_sf. DR InterPro; IPR002389; ANX2. DR PANTHER; PTHR10502:SF18; PTHR10502:SF18; 1. DR Pfam; PF00191; Annexin; 4. DR PRINTS; PR00196; ANNEXIN. DR PRINTS; PR00198; ANNEXINII. DR SMART; SM00335; ANX; 4. DR SUPFAM; SSF47874; SSF47874; 1. DR PROSITE; PS00223; ANNEXIN_1; 2. DR PROSITE; PS51897; ANNEXIN_2; 4. PE 3: Inferred from homology; KW Annexin {ECO:0000256|ARBA:ARBA00023216, ECO:0000256|RuleBase:RU003540}; KW Basement membrane {ECO:0000256|ARBA:ARBA00022869}; KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU003540}; KW Calcium/phospholipid-binding {ECO:0000256|ARBA:ARBA00023302, KW ECO:0000256|RuleBase:RU003540}; KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU003540}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}. SQ SEQUENCE 442 AA; 49978 MW; A0624289098E090C CRC64; MFPATVCVCV WVSHYESGEV LGSGRRGEGK GGGPGRGGAG TLLLLRMWQS IKTPPKTSRL CLKPDKLPAL SVLGAASFKM STVHEILCKL NLEGDHSTPA SAYGSVKAYN NFDAERDAIN IEAAIKTKDL KFEAIRKDEI VKEMDWIRKY MKGVDEVTIV NILTNRSNEQ RQDIAFAYQR RTKKELASAL KSALSGHLET VILGLLKTPA QYDASELKAS MKGLGTDEDS LIEIICSRTN QELYEINKVY REMYKTELEK DIISDTSGDF RKLMVALAKG KRAEDGSVID YELIDQDARE LYDAGVKRKG TDVPKWISIM TERSVCHLQK VFERYKSYSP YDMLESIKKE VKGDLENAFL NLVQCIQNKP LYFADRLYDS MKGKGTRDKV LIRIMVSRSE VDMLKIRSEF KRKYGKSLYY FIQQDTKGDY QKALLYLCGG DD //