ID A0A7N4P2I9_SARHA Unreviewed; 544 AA. AC A0A7N4P2I9; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 27-MAR-2024, entry version 11. DE RecName: Full=C-type lectin domain-containing protein {ECO:0000259|PROSITE:PS50041}; GN Name=DGCR2 {ECO:0000313|Ensembl:ENSSHAP00000031754.1}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000031754.1, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000031754.1, ECO:0000313|Proteomes:UP000007648} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J., RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C., RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P., RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M., RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M., RA Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered marsupial RT Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000031754.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A7N4P2I9; -. DR Ensembl; ENSSHAT00000048284.1; ENSSHAP00000031754.1; ENSSHAG00000006909.2. DR GeneTree; ENSGT00390000017655; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. DR CDD; cd03599; CLECT_DGCR2_like; 1. DR CDD; cd00112; LDLa; 1. DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1. DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1. DR InterPro; IPR001304; C-type_lectin-like. DR InterPro; IPR016186; C-type_lectin-like/link_sf. DR InterPro; IPR016187; CTDL_fold. DR InterPro; IPR034010; DGCR2-like_CTLD. DR InterPro; IPR042378; IDD. DR InterPro; IPR036055; LDL_receptor-like_sf. DR InterPro; IPR023415; LDLR_class-A_CS. DR InterPro; IPR002172; LDrepeatLR_classA_rpt. DR InterPro; IPR001007; VWF_dom. DR PANTHER; PTHR15256; INTEGRAL MEMBRANE PROTEIN DGCR2/IDD; 1. DR PANTHER; PTHR15256:SF6; INTEGRAL MEMBRANE PROTEIN DGCR2_IDD; 1. DR Pfam; PF00057; Ldl_recept_a; 1. DR Pfam; PF00059; Lectin_C; 1. DR SMART; SM00034; CLECT; 1. DR SMART; SM00192; LDLa; 1. DR SMART; SM00214; VWC; 1. DR SUPFAM; SSF56436; C-type lectin-like; 1. DR SUPFAM; SSF57424; LDL receptor-like module; 1. DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1. DR PROSITE; PS01209; LDLRA_1; 1. DR PROSITE; PS50068; LDLRA_2; 1. PE 4: Predicted; KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE- KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 24..544 FT /note="C-type lectin domain-containing protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5029672104" FT TRANSMEM 347..367 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 123..265 FT /note="C-type lectin" FT /evidence="ECO:0000259|PROSITE:PS50041" FT REGION 62..93 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 433..544 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 73..93 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 433..453 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 51..66 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" SQ SEQUENCE 544 AA; 59944 MW; 943BDFA82190870F CRC64; MVPQADSGAF VLLFLLVLTG TEPLRPESRC NPGQFACRSG AIQCIPLSWQ CDGRGTCEDE SDEVGCPDVP GDQRSYHGKE AMDSRPSRGR GDKTRFHTVN VAQPVRFSSF LGKCLTGWHH YEGTASCYKV YLNGENYWDA VQTCQRVNGS LVAFTTDEEL RFVLAQEWDL QERTFGWKDQ RKFWVGYQYV ITGRNRSLEG RWEVAHKGPS EVFLPPDPIF ASAVPENDNV LCAQLQCFHF PTLRHHDLHS WYAENCYEKS SFLCKRSQTC VDIKDNVVGE GYHFTPKGND PCLSCTCHNG EPEMCVAALC EGPQGCQQYD KDPKECCKFM CLDPDGSSLF DSMASGMRLI VSCISSFLIL SLLLFMVHRL RQRRRERIES LIGANLHHFN LGRRIPGFDY GPDGFGTGLT PLHLSDDGEG GAFHFHDPPP PYTAYKYPDI QHPDDPPPPY EASVDPGSTL CASPDGVCPQ VAQSDPPSLG DSEASPQLPE GPPPPSVGPS PAELDDSADS STLLVPPDTP LSENGPAETL GGSRPSLCSL NTIV //