ID   A0A7M7STY2_STRPU        Unreviewed;       485 AA.
AC   A0A7M7STY2;
DT   07-APR-2021, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 1.
DT   28-JUN-2023, entry version 7.
DE   RecName: Full=O-acyltransferase {ECO:0000256|PIRNR:PIRNR000439};
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668 {ECO:0000313|EnsemblMetazoa:XP_030831201, ECO:0000313|Proteomes:UP000007110};
RN   [1] {ECO:0000313|Proteomes:UP000007110}
RP   NUCLEOTIDE SEQUENCE.
RA   Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y.,
RA   Muzny D.M., Worley K.C., Gibbs R.A.;
RT   "Genome sequencing for Strongylocentrotus purpuratus.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:XP_030831201}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JAN-2021) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+)
CC         = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O; Xref=Rhea:RHEA:38379,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823,
CC         ChEBI:CHEBI:52323, ChEBI:CHEBI:53753;
CC         Evidence={ECO:0000256|ARBA:ARBA00000645};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38380;
CC         Evidence={ECO:0000256|ARBA:ARBA00000645};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol =
CC         1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38219,
CC         ChEBI:CHEBI:52333, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57387; Evidence={ECO:0000256|ARBA:ARBA00000389};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38220;
CC         Evidence={ECO:0000256|ARBA:ARBA00000389};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol =
CC         1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38435,
CC         ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387,
CC         ChEBI:CHEBI:75735; Evidence={ECO:0000256|ARBA:ARBA00000883};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38436;
CC         Evidence={ECO:0000256|ARBA:ARBA00000883};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-
CC         (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:37915,
CC         ChEBI:CHEBI:52323, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387,
CC         ChEBI:CHEBI:75342; Evidence={ECO:0000256|ARBA:ARBA00001009};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37916;
CC         Evidence={ECO:0000256|ARBA:ARBA00001009};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-
CC         (9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA;
CC         Xref=Rhea:RHEA:55340, ChEBI:CHEBI:34116, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57387, ChEBI:CHEBI:138734;
CC         Evidence={ECO:0000256|ARBA:ARBA00000304};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55341;
CC         Evidence={ECO:0000256|ARBA:ARBA00000304};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-
CC         octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-
CC         octadecenoyl)glycerol + CoA; Xref=Rhea:RHEA:55344, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57387, ChEBI:CHEBI:138734, ChEBI:CHEBI:138735;
CC         Evidence={ECO:0000256|ARBA:ARBA00000605};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55345;
CC         Evidence={ECO:0000256|ARBA:ARBA00000605};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-
CC         eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-
CC         eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA;
CC         Xref=Rhea:RHEA:38307, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387,
CC         ChEBI:CHEBI:75728, ChEBI:CHEBI:75729;
CC         Evidence={ECO:0000256|ARBA:ARBA00001100};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38308;
CC         Evidence={ECO:0000256|ARBA:ARBA00001100};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol =
CC         1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38439,
CC         ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387,
CC         ChEBI:CHEBI:75824; Evidence={ECO:0000256|ARBA:ARBA00001338};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38440;
CC         Evidence={ECO:0000256|ARBA:ARBA00001338};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-
CC         (9Z-octadecenoyl)-sn-glycerol + CoA; Xref=Rhea:RHEA:37911,
CC         ChEBI:CHEBI:52333, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387,
CC         ChEBI:CHEBI:73990; Evidence={ECO:0000256|ARBA:ARBA00001793};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37912;
CC         Evidence={ECO:0000256|ARBA:ARBA00001793};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-
CC         di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA;
CC         Xref=Rhea:RHEA:38163, ChEBI:CHEBI:52333, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57379, ChEBI:CHEBI:75583;
CC         Evidence={ECO:0000256|ARBA:ARBA00001349};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38164;
CC         Evidence={ECO:0000256|ARBA:ARBA00001349};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl
CC         hexadecanoate + CoA; Xref=Rhea:RHEA:55296, ChEBI:CHEBI:45479,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:138722;
CC         Evidence={ECO:0000256|ARBA:ARBA00000895};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55297;
CC         Evidence={ECO:0000256|ARBA:ARBA00000895};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-
CC         hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA;
CC         Xref=Rhea:RHEA:38071, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379,
CC         ChEBI:CHEBI:73990, ChEBI:CHEBI:75466;
CC         Evidence={ECO:0000256|ARBA:ARBA00001313};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38072;
CC         Evidence={ECO:0000256|ARBA:ARBA00001313};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol
CC         + CoA; Xref=Rhea:RHEA:10868, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:58342, ChEBI:CHEBI:64615; EC=2.3.1.20;
CC         Evidence={ECO:0000256|ARBA:ARBA00001150};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10869;
CC         Evidence={ECO:0000256|ARBA:ARBA00001150};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester +
CC         CoA; Xref=Rhea:RHEA:11488, ChEBI:CHEBI:17336, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:58342, ChEBI:CHEBI:63410; EC=2.3.1.76;
CC         Evidence={ECO:0000256|ARBA:ARBA00000633};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11489;
CC         Evidence={ECO:0000256|ARBA:ARBA00000633};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl
CC         hexadecanoate + CoA; Xref=Rhea:RHEA:38175, ChEBI:CHEBI:17336,
CC         ChEBI:CHEBI:17616, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379;
CC         Evidence={ECO:0000256|ARBA:ARBA00001764};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38176;
CC         Evidence={ECO:0000256|ARBA:ARBA00001764};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl
CC         hexadecanoate; Xref=Rhea:RHEA:38167, ChEBI:CHEBI:16125,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75584;
CC         Evidence={ECO:0000256|ARBA:ARBA00001796};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38168;
CC         Evidence={ECO:0000256|ARBA:ARBA00001796};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-
CC         dihexadecanoyl-1,2-hexadecanediol + 2 CoA; Xref=Rhea:RHEA:38211,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75586,
CC         ChEBI:CHEBI:75608; Evidence={ECO:0000256|ARBA:ARBA00001118};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38212;
CC         Evidence={ECO:0000256|ARBA:ARBA00001118};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl
CC         hexadecanoate + CoA; Xref=Rhea:RHEA:38171, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57379, ChEBI:CHEBI:75586, ChEBI:CHEBI:75587;
CC         Evidence={ECO:0000256|ARBA:ARBA00000174};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38172;
CC         Evidence={ECO:0000256|ARBA:ARBA00000174};
CC   -!- PATHWAY: Lipid metabolism; glycerolipid metabolism.
CC       {ECO:0000256|ARBA:ARBA00005175}.
CC   -!- SUBUNIT: Homodimer or homotetramer; both forms have similar enzymatic
CC       activities. {ECO:0000256|ARBA:ARBA00023610}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|PIRNR:PIRNR000439}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC       ECO:0000256|PIRNR:PIRNR000439}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
CC       Sterol o-acyltransferase subfamily. {ECO:0000256|ARBA:ARBA00009010,
CC       ECO:0000256|PIRNR:PIRNR000439}.
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DR   AlphaFoldDB; A0A7M7STY2; -.
DR   EnsemblMetazoa; XM_030975341; XP_030831201; LOC575003.
DR   EnsemblMetazoa; XM_030975342; XP_030831202; LOC575003.
DR   InParanoid; A0A7M7STY2; -.
DR   OMA; SCLSHDS; -.
DR   UniPathway; UPA00230; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0004144; F:diacylglycerol O-acyltransferase activity; IBA:GO_Central.
DR   GO; GO:0050252; F:retinol O-fatty-acyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019432; P:triglyceride biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR027251; Diacylglycerol_acylTrfase1.
DR   InterPro; IPR004299; MBOAT_fam.
DR   InterPro; IPR014371; Oat_ACAT_DAG_ARE.
DR   PANTHER; PTHR10408:SF7; DIACYLGLYCEROL O-ACYLTRANSFERASE 1; 1.
DR   PANTHER; PTHR10408; STEROL O-ACYLTRANSFERASE; 1.
DR   Pfam; PF03062; MBOAT; 1.
DR   PIRSF; PIRSF000439; Oat_ACAT_DAG_ARE; 1.
DR   PIRSF; PIRSF500231; Oat_dag; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|PIRNR:PIRNR000439};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|PIRNR:PIRNR000439};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR000439};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007110};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000439};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        46..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        87..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        120..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        150..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        276..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        322..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        399..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        444..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          182..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        409
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000439-1"
SQ   SEQUENCE   485 AA;  56307 MW;  1DFD8E8C660A98F0 CRC64;
     MAEQMGDNKK HTSGQDASVK RPDVPIHKPR DSLLSNSSGF NNYRGFLNLC IVLLAMSSSR
     LVLENLIKYG IIMDPIKWFS VFLQDPYSWP NFTLLILLNG FILYAFWLEK LMLKAYIQER
     TMTVLVTLNV MTVFIFPVIV ILYYKPNPVG SFASLGTYSI AFLKLISYAA VNKWCRDAQS
     STSKKSKKSA NSSDDSLSRN SPRRHSTPQP RKRVTNRRRS EGSNEEANGE QAELVEYPNN
     LTLNDMCYFM MVPTLCYELN FPRTKRIRKR FLIRRIIELV FLVQLCLCLV QQWIVPTVLN
     ALAPFTSLDT KRMLERVLKL AVPNHICWLI FFYSFFHSWL NVLGEVTKFA DRNFYQDWWN
     AETISYFWKN WNIPVHKWCL RHLYFPLRSK GVDQQKAQII VFLVSAIFHE YLVSIPLQMF
     RLWAFGGMLA QLPLVKLTSK VKGHWGNVLV WLSLIIGQPV AVLMYFHDYY VMHAAINVNG
     TSTTP
//