ID A0A7M7STY2_STRPU Unreviewed; 485 AA. AC A0A7M7STY2; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 03-MAY-2023, entry version 6. DE RecName: Full=O-acyltransferase {ECO:0000256|PIRNR:PIRNR000439}; OS Strongylocentrotus purpuratus (Purple sea urchin). OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea; OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae; OC Strongylocentrotus. OX NCBI_TaxID=7668 {ECO:0000313|EnsemblMetazoa:XP_030831201, ECO:0000313|Proteomes:UP000007110}; RN [1] {ECO:0000313|Proteomes:UP000007110} RP NUCLEOTIDE SEQUENCE. RA Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y., RA Muzny D.M., Worley K.C., Gibbs R.A.; RT "Genome sequencing for Strongylocentrotus purpuratus."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EnsemblMetazoa:XP_030831201} RP IDENTIFICATION. RG EnsemblMetazoa; RL Submitted (JAN-2021) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) CC = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O; Xref=Rhea:RHEA:38379, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, CC ChEBI:CHEBI:52323, ChEBI:CHEBI:53753; CC Evidence={ECO:0000256|ARBA:ARBA00000645}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38380; CC Evidence={ECO:0000256|ARBA:ARBA00000645}; CC -!- CATALYTIC ACTIVITY: CC Reaction=(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = CC 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38219, CC ChEBI:CHEBI:52333, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, CC ChEBI:CHEBI:57387; Evidence={ECO:0000256|ARBA:ARBA00000389}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38220; CC Evidence={ECO:0000256|ARBA:ARBA00000389}; CC -!- CATALYTIC ACTIVITY: CC Reaction=(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = CC 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38435, CC ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, CC ChEBI:CHEBI:75735; Evidence={ECO:0000256|ARBA:ARBA00000883}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38436; CC Evidence={ECO:0000256|ARBA:ARBA00000883}; CC -!- CATALYTIC ACTIVITY: CC Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di- CC (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:37915, CC ChEBI:CHEBI:52323, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, CC ChEBI:CHEBI:75342; Evidence={ECO:0000256|ARBA:ARBA00001009}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37916; CC Evidence={ECO:0000256|ARBA:ARBA00001009}; CC -!- CATALYTIC ACTIVITY: CC Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O- CC (9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA; CC Xref=Rhea:RHEA:55340, ChEBI:CHEBI:34116, ChEBI:CHEBI:57287, CC ChEBI:CHEBI:57387, ChEBI:CHEBI:138734; CC Evidence={ECO:0000256|ARBA:ARBA00000304}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55341; CC Evidence={ECO:0000256|ARBA:ARBA00000304}; CC -!- CATALYTIC ACTIVITY: CC Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z- CC octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z- CC octadecenoyl)glycerol + CoA; Xref=Rhea:RHEA:55344, ChEBI:CHEBI:57287, CC ChEBI:CHEBI:57387, ChEBI:CHEBI:138734, ChEBI:CHEBI:138735; CC Evidence={ECO:0000256|ARBA:ARBA00000605}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55345; CC Evidence={ECO:0000256|ARBA:ARBA00000605}; CC -!- CATALYTIC ACTIVITY: CC Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z- CC eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)- CC eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA; CC Xref=Rhea:RHEA:38307, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, CC ChEBI:CHEBI:75728, ChEBI:CHEBI:75729; CC Evidence={ECO:0000256|ARBA:ARBA00001100}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38308; CC Evidence={ECO:0000256|ARBA:ARBA00001100}; CC -!- CATALYTIC ACTIVITY: CC Reaction=(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = CC 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38439, CC ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, CC ChEBI:CHEBI:75824; Evidence={ECO:0000256|ARBA:ARBA00001338}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38440; CC Evidence={ECO:0000256|ARBA:ARBA00001338}; CC -!- CATALYTIC ACTIVITY: CC Reaction=(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di- CC (9Z-octadecenoyl)-sn-glycerol + CoA; Xref=Rhea:RHEA:37911, CC ChEBI:CHEBI:52333, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, CC ChEBI:CHEBI:73990; Evidence={ECO:0000256|ARBA:ARBA00001793}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37912; CC Evidence={ECO:0000256|ARBA:ARBA00001793}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2- CC di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA; CC Xref=Rhea:RHEA:38163, ChEBI:CHEBI:52333, ChEBI:CHEBI:57287, CC ChEBI:CHEBI:57379, ChEBI:CHEBI:75583; CC Evidence={ECO:0000256|ARBA:ARBA00001349}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38164; CC Evidence={ECO:0000256|ARBA:ARBA00001349}; CC -!- CATALYTIC ACTIVITY: CC Reaction=13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl CC hexadecanoate + CoA; Xref=Rhea:RHEA:55296, ChEBI:CHEBI:45479, CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:138722; CC Evidence={ECO:0000256|ARBA:ARBA00000895}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55297; CC Evidence={ECO:0000256|ARBA:ARBA00000895}; CC -!- CATALYTIC ACTIVITY: CC Reaction=2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1- CC hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA; CC Xref=Rhea:RHEA:38071, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, CC ChEBI:CHEBI:73990, ChEBI:CHEBI:75466; CC Evidence={ECO:0000256|ARBA:ARBA00001313}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38072; CC Evidence={ECO:0000256|ARBA:ARBA00001313}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol CC + CoA; Xref=Rhea:RHEA:10868, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287, CC ChEBI:CHEBI:58342, ChEBI:CHEBI:64615; EC=2.3.1.20; CC Evidence={ECO:0000256|ARBA:ARBA00001150}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10869; CC Evidence={ECO:0000256|ARBA:ARBA00001150}; CC -!- CATALYTIC ACTIVITY: CC Reaction=all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CC CoA; Xref=Rhea:RHEA:11488, ChEBI:CHEBI:17336, ChEBI:CHEBI:57287, CC ChEBI:CHEBI:58342, ChEBI:CHEBI:63410; EC=2.3.1.76; CC Evidence={ECO:0000256|ARBA:ARBA00000633}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11489; CC Evidence={ECO:0000256|ARBA:ARBA00000633}; CC -!- CATALYTIC ACTIVITY: CC Reaction=all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl CC hexadecanoate + CoA; Xref=Rhea:RHEA:38175, ChEBI:CHEBI:17336, CC ChEBI:CHEBI:17616, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; CC Evidence={ECO:0000256|ARBA:ARBA00001764}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38176; CC Evidence={ECO:0000256|ARBA:ARBA00001764}; CC -!- CATALYTIC ACTIVITY: CC Reaction=hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl CC hexadecanoate; Xref=Rhea:RHEA:38167, ChEBI:CHEBI:16125, CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75584; CC Evidence={ECO:0000256|ARBA:ARBA00001796}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38168; CC Evidence={ECO:0000256|ARBA:ARBA00001796}; CC -!- CATALYTIC ACTIVITY: CC Reaction=hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O- CC dihexadecanoyl-1,2-hexadecanediol + 2 CoA; Xref=Rhea:RHEA:38211, CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75586, CC ChEBI:CHEBI:75608; Evidence={ECO:0000256|ARBA:ARBA00001118}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38212; CC Evidence={ECO:0000256|ARBA:ARBA00001118}; CC -!- CATALYTIC ACTIVITY: CC Reaction=hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl CC hexadecanoate + CoA; Xref=Rhea:RHEA:38171, ChEBI:CHEBI:57287, CC ChEBI:CHEBI:57379, ChEBI:CHEBI:75586, ChEBI:CHEBI:75587; CC Evidence={ECO:0000256|ARBA:ARBA00000174}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38172; CC Evidence={ECO:0000256|ARBA:ARBA00000174}; CC -!- PATHWAY: Lipid metabolism; glycerolipid metabolism. CC {ECO:0000256|ARBA:ARBA00005175}. CC -!- SUBUNIT: Homodimer or homotetramer; both forms have similar enzymatic CC activities. {ECO:0000256|ARBA:ARBA00023610}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|PIRNR:PIRNR000439}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477, CC ECO:0000256|PIRNR:PIRNR000439}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the membrane-bound acyltransferase family. CC Sterol o-acyltransferase subfamily. {ECO:0000256|ARBA:ARBA00009010, CC ECO:0000256|PIRNR:PIRNR000439}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A7M7STY2; -. DR EnsemblMetazoa; XM_030975341; XP_030831201; LOC575003. DR EnsemblMetazoa; XM_030975342; XP_030831202; LOC575003. DR OMA; SCLSHDS; -. DR UniPathway; UPA00230; -. DR Proteomes; UP000007110; Unassembled WGS sequence. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central. DR GO; GO:0004144; F:diacylglycerol O-acyltransferase activity; IBA:GO_Central. DR GO; GO:0050252; F:retinol O-fatty-acyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0019432; P:triglyceride biosynthetic process; IBA:GO_Central. DR InterPro; IPR027251; Diacylglycerol_acylTrfase1. DR InterPro; IPR004299; MBOAT_fam. DR InterPro; IPR014371; Oat_ACAT_DAG_ARE. DR PANTHER; PTHR10408:SF7; DIACYLGLYCEROL O-ACYLTRANSFERASE 1; 1. DR PANTHER; PTHR10408; STEROL O-ACYLTRANSFERASE; 1. DR Pfam; PF03062; MBOAT; 1. DR PIRSF; PIRSF000439; Oat_ACAT_DAG_ARE; 1. DR PIRSF; PIRSF500231; Oat_dag; 1. PE 3: Inferred from homology; KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315, KW ECO:0000256|PIRNR:PIRNR000439}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824, KW ECO:0000256|PIRNR:PIRNR000439}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR000439}; KW Reference proteome {ECO:0000313|Proteomes:UP000007110}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000439}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 46..67 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 87..108 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 120..144 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 150..171 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 276..302 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 322..343 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 399..424 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 444..466 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT REGION 1..30 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 182..230 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..28 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 409 FT /evidence="ECO:0000256|PIRSR:PIRSR000439-1" SQ SEQUENCE 485 AA; 56307 MW; 1DFD8E8C660A98F0 CRC64; MAEQMGDNKK HTSGQDASVK RPDVPIHKPR DSLLSNSSGF NNYRGFLNLC IVLLAMSSSR LVLENLIKYG IIMDPIKWFS VFLQDPYSWP NFTLLILLNG FILYAFWLEK LMLKAYIQER TMTVLVTLNV MTVFIFPVIV ILYYKPNPVG SFASLGTYSI AFLKLISYAA VNKWCRDAQS STSKKSKKSA NSSDDSLSRN SPRRHSTPQP RKRVTNRRRS EGSNEEANGE QAELVEYPNN LTLNDMCYFM MVPTLCYELN FPRTKRIRKR FLIRRIIELV FLVQLCLCLV QQWIVPTVLN ALAPFTSLDT KRMLERVLKL AVPNHICWLI FFYSFFHSWL NVLGEVTKFA DRNFYQDWWN AETISYFWKN WNIPVHKWCL RHLYFPLRSK GVDQQKAQII VFLVSAIFHE YLVSIPLQMF RLWAFGGMLA QLPLVKLTSK VKGHWGNVLV WLSLIIGQPV AVLMYFHDYY VMHAAINVNG TSTTP //