ID A0A7M3RDA6_SPIER Unreviewed; 410 AA. AC A0A7M3RDA6; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 19-JAN-2022, entry version 4. DE RecName: Full=Inhibitor of kappa B-like protein {ECO:0000256|ARBA:ARBA00016262}; DE AltName: Full=NF-kappa-B inhibitor-like protein 1 {ECO:0000256|ARBA:ARBA00014259}; DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 {ECO:0000256|ARBA:ARBA00013990}; GN ORFNames=SERJ2_LOCUS17986 {ECO:0000313|EMBL:VZI37100.1}; OS Spirometra erinaceieuropaei (Tapeworm) (Spirometra erinacei). OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda; OC Eucestoda; Diphyllobothriidea; Diphyllobothriidae; Spirometra. OX NCBI_TaxID=99802 {ECO:0000313|EMBL:VZI37100.1, ECO:0000313|Proteomes:UP000550142}; RN [1] {ECO:0000313|EMBL:VZI37100.1, ECO:0000313|Proteomes:UP000550142} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SerJ.yamaguchi {ECO:0000313|EMBL:VZI37100.1}; RA Kikuchi T.; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the regulation of innate immune response. Acts as CC negative regulator of Toll-like receptor and interferon-regulatory CC factor (IRF) signaling pathways. Contributes to the negative regulation CC of transcriptional activation of NF-kappa-B target genes in response to CC endogenous proinflammatory stimuli. {ECO:0000256|ARBA:ARBA00024751}. CC -!- SUBUNIT: Interacts with CACTIN (via N-terminal domain); the interaction CC occurs in a proinflammatory-independent manner. CC {ECO:0000256|ARBA:ARBA00011310}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:VZI37100.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CACRXP010000466; VZI37100.1; -; Genomic_DNA. DR Proteomes; UP000550142; Unassembled WGS sequence. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:InterPro. DR Gene3D; 1.25.40.20; -; 1. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR InterPro; IPR038753; NFKBIL1. DR PANTHER; PTHR15263; PTHR15263; 1. DR Pfam; PF13637; Ank_4; 1. DR SUPFAM; SSF48403; SSF48403; 1. DR PROSITE; PS50088; ANK_REPEAT; 1. PE 4: Predicted; KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}; KW Reference proteome {ECO:0000313|Proteomes:UP000550142}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}. FT REPEAT 70..102 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REGION 182..203 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 410 AA; 46446 MW; BFAF555FC435649B CRC64; MRPIWVQSLK SPDESKALSK ILLKLVKKGR LRRLQALLRE SVAHDVGSTT SASCNGAAAV YLLASIVDKR GRRLLHIACE QGHLRMLRFL VELGLPIEVF DKAGNSPAHS CLKYGVRFHR FAKCCELLVA LLARNTELLY VRNNAGVSPV SLLESLWRLS PLHEREKGDE ILMDFQELTD EFSSEPPTGF AATPTSSRET GTSNVEWNQR LLDELRFSQT SHEDYFSGFV ETDTSEDPFE TIRIEYERRH RRPTVNTRQT PTTSSAASVE QERQQFFQRH AEGLRKRGFL FTAAPARKSQ LSEFLSQWQA FLSDHEPLTL GNLSHIPWLP VAEGDVPGLL RFVGHNFASL RQLQVDWHPD RFFSRLAPRL ASEDVRRALT GRVNAISQLL NEGVAELRRH KADTQTAPNS //