ID   A0A7L4L9T0_9CORV        Unreviewed;       897 AA.
AC   A0A7L4L9T0;
DT   07-APR-2021, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 1.
DT   24-JUL-2024, entry version 10.
DE   SubName: Full=ITIH2 inhibitor {ECO:0000313|EMBL:NXY61718.1};
DE   Flags: Fragment;
GN   Name=Itih2 {ECO:0000313|EMBL:NXY61718.1};
GN   ORFNames=CALWIL_R11125 {ECO:0000313|EMBL:NXY61718.1};
OS   Callaeas wilsoni (North Island kokako).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Callaeidae;
OC   Callaeas.
OX   NCBI_TaxID=1347786 {ECO:0000313|EMBL:NXY61718.1, ECO:0000313|Proteomes:UP000576729};
RN   [1] {ECO:0000313|EMBL:NXY61718.1, ECO:0000313|Proteomes:UP000576729}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B10K-OTA-212792 {ECO:0000313|EMBL:NXY61718.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:NXY61718.1};
RA   Zhang G.;
RT   "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the ITIH family.
CC       {ECO:0000256|ARBA:ARBA00010158}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:NXY61718.1}.
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DR   EMBL; VWPU01014281; NXY61718.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A7L4L9T0; -.
DR   Proteomes; UP000576729; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR050934; ITIH.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF14; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2; 1.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000576729};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          7..136
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          261..444
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:NXY61718.1"
FT   NON_TER         897
FT                   /evidence="ECO:0000313|EMBL:NXY61718.1"
SQ   SEQUENCE   897 AA;  100595 MW;  7BB2F09D637FB6EA CRC64;
     FQRSTSDWGY VGDLVEDDDK IGLYSYKVQS TITSRLANTM IQAKMVNNAK RPQPIMFDVQ
     VPKGAFIDNF TMDINGITFT SHIREKSEAR KMYAQAKAKG KAAGIVRSNA LDMENFQTEV
     NVPPGMRIQF QLHYHEMIRR KLSSYEHVIS VKPGRLAKHM EVDVRIIEPQ GLRYVHVPNS
     LGDHFDGITT ISKGEKKAHV SFKPTMAQQR KCPKCSSTAV DGNFVVQYDV NRETTGGELE
     IFNGYFIHFF APENLDPLPK NILFVIDVSG SMWGLKMKQT IEAMKAILSE LRAADQFSLI
     DFNHNVRCWR DNLVSATPSQ VEDAKKYIQT IHPNGGTNIN EALLRATFIL NEAKSLGMLD
     PNSVSMIVLV SDGDPTVGEL KLTTIQKNVK QSIKDEFSLF CLGIGFDVDY DFLQRIATDN
     RGMAQRIFGN QETSLQMKNF YNQVSTPLLK KIQFNYPQES VSDVTQSSFH NYFGGSEIVV
     AGKVDTENLQ HLESVVTATA ANAELVMETL RDVEELDGFM KKDKYADPEF TRKLWAYLTV
     NQMMAERNAA PTAALKRNIT KSILQMSLDH HIVTPFTAML IENAEKDEIM LADQPKDPRK
     GCCPGTLGLT PNAPNNNKGI PAWANVTAVP VSFMPEQRSP PVSSLSINRV DNDPHFIIHL
     PKSQRNICFN INSEPGKILN LVSDPGTGVV VNGQLVGAKK AENEKLNTYF GKIGFYFKKK
     GLKVEITTET ITLKDGSYAT TLTWADTGHI IRKQLLISVK KESNVTITVG EEMSFMVLLH
     RVWKKHPVNV DFLGIYIPPE NQFSPAAHGL IGQFASEPEV SIHHQTPGQA PEKPQAIMEV
     KGNKFTVTRG VQKDYRTDRV LGTDVLCWFV HNSGKGFIDG HYRDYLVPHL YSFMKKP
//