ID A0A7L2PVC2_9PASS Unreviewed; 715 AA. AC A0A7L2PVC2; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 25-MAY-2022, entry version 5. DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365}; DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728}; DE Flags: Fragment; GN Name=Mpeg1 {ECO:0000313|EMBL:NXR88580.1}; GN ORFNames=HYPCIN_R09901 {ECO:0000313|EMBL:NXR88580.1}; OS Hypocryptadius cinnamomeus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Zosteropidae; OC Hypocryptadius. OX NCBI_TaxID=589841 {ECO:0000313|EMBL:NXR88580.1, ECO:0000313|Proteomes:UP000574191}; RN [1] {ECO:0000313|EMBL:NXR88580.1, ECO:0000313|Proteomes:UP000574191} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B10K-DU-002-83 {ECO:0000313|EMBL:NXR88580.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane CC {ECO:0000256|ARBA:ARBA00004358}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004358}. Membrane CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the MPEG1 family. CC {ECO:0000256|ARBA:ARBA00007256}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NXR88580.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VYZP01025230; NXR88580.1; -; Genomic_DNA. DR Proteomes; UP000574191; Unassembled WGS sequence. DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR InterPro; IPR020864; MACPF. DR InterPro; IPR039707; MPEG1. DR PANTHER; PTHR31463; PTHR31463; 1. DR Pfam; PF01823; MACPF; 1. DR SMART; SM00457; MACPF; 1. DR PROSITE; PS51412; MACPF_2; 1. PE 3: Inferred from homology; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000574191}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}. FT SIGNAL 1..21 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 22..715 FT /note="Macrophage-expressed gene 1 protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5029541539" FT TRANSMEM 653..674 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 32..347 FT /note="MACPF" FT /evidence="ECO:0000259|PROSITE:PS51412" FT REGION 689..715 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NXR88580.1" FT NON_TER 715 FT /evidence="ECO:0000313|EMBL:NXR88580.1" SQ SEQUENCE 715 AA; 77649 MW; 94DFEDC7FE905E60 CRC64; MGWGLWGASL TWALLAWVTG AEQPQELSSS SGVGVCSKTL KLSRLEVLPG GGWDNLRNLD MGRVINLGYS QCKTTEDGSY LIPDEIFTIP RKQSNLDINS EIIESWKDYQ SITSASINLE LSLFSSINGK FSSDFHRTKT HQVRDKAVTT RVQVRNLVYT AKIDPEAALD KAFKKQLLTI ASHLENNQTQ MADFLAEVLV LNYGTHAITS VDAGATLVQE DQIKATFLKD SWATRNTVTA SAGVAFHSIV NVGTKESLDI SSGFTKQYLD NRTNSRVESI GGTPFYPGIT LKAWQERIHN QLVALDRSGL PLYYFIKPSA LPELPVPTVR RVAQRVELAI RRYYTFNTAL GCTDASSPNF NFHANTDDGS CEGTMANFTF GGVFQECVGL GGPDTDTLCR ALEQRNPLTG AFSCPASYTP VLLGVQEREE GHSHLECHNK CTLGIFCHRK CQDVFWLSRV QFSTYWCAAS GPVAPNSGYL FGGLFSTHGA NPITGAQSCP SGYFPLKLFG ELRVCVSQDY EAGAEYAVPF GGFFSCQTGN PLAGQHRGTA EDPHAKGCPP GFSQHLALIS DSCQVQFCVQ AGLLTGGSLP PARLPPFTRP PANLPAVDTL LVRDGDNTWV RDGQSHVWRL ARPEEVQFAA EMVRGRGLSG GEVAGVTVAV LAGLATSLGM AWYGHRRYRA RGYRALGAGD SPAPASPEHS TVLSMGEGYQ QELEG //