ID A0A7L2MCQ9_9PASS Unreviewed; 1004 AA. AC A0A7L2MCQ9; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 02-JUN-2021, entry version 2. DE RecName: Full=Trifunctional purine biosynthetic protein adenosine-3 {ECO:0000256|RuleBase:RU363089}; DE Includes: DE RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|RuleBase:RU363089}; DE EC=6.3.4.13 {ECO:0000256|RuleBase:RU363089}; DE AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|RuleBase:RU363089}; DE Short=GARS {ECO:0000256|RuleBase:RU363089}; DE AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|RuleBase:RU363089}; DE Includes: DE RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase {ECO:0000256|RuleBase:RU363089}; DE EC=6.3.3.1 {ECO:0000256|RuleBase:RU363089}; DE AltName: Full=AIR synthase {ECO:0000256|RuleBase:RU363089}; DE Short=AIRS {ECO:0000256|RuleBase:RU363089}; DE AltName: Full=Phosphoribosyl-aminoimidazole synthetase {ECO:0000256|RuleBase:RU363089}; DE Includes: DE RecName: Full=Phosphoribosylglycinamide formyltransferase {ECO:0000256|RuleBase:RU363089}; DE EC=2.1.2.2 {ECO:0000256|RuleBase:RU363089}; DE AltName: Full=5'-phosphoribosylglycinamide transformylase {ECO:0000256|RuleBase:RU363089}; DE AltName: Full=GAR transformylase {ECO:0000256|RuleBase:RU363089}; DE Short=GART {ECO:0000256|RuleBase:RU363089}; DE Flags: Fragment; GN Name=Gart {ECO:0000313|EMBL:NXR57720.1}; GN ORFNames=RHASIB_R11283 {ECO:0000313|EMBL:NXR57720.1}; OS Rhadina sibilatrix. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Phylloscopidae; OC Rhadina. OX NCBI_TaxID=2585818 {ECO:0000313|EMBL:NXR57720.1, ECO:0000313|Proteomes:UP000587697}; RN [1] {ECO:0000313|EMBL:NXR57720.1, ECO:0000313|Proteomes:UP000587697} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B10K-DU-002-26 {ECO:0000313|EMBL:NXR57720.1}; RC TISSUE=Muscle {ECO:0000313|EMBL:NXR57720.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D- CC ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)- CC formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide; CC Xref=Rhea:RHEA:15053, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453, CC ChEBI:CHEBI:57454, ChEBI:CHEBI:143788, ChEBI:CHEBI:147286; CC EC=2.1.2.2; Evidence={ECO:0000256|ARBA:ARBA00001429, CC ECO:0000256|RuleBase:RU363089}; CC -!- CATALYTIC ACTIVITY: CC Reaction=2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP CC = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + CC phosphate; Xref=Rhea:RHEA:23032, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:137981, CC ChEBI:CHEBI:147287, ChEBI:CHEBI:456216; EC=6.3.3.1; CC Evidence={ECO:0000256|ARBA:ARBA00023392, CC ECO:0000256|RuleBase:RU363089}; CC -!- CATALYTIC ACTIVITY: CC Reaction=5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + CC N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate; CC Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58681, CC ChEBI:CHEBI:143788, ChEBI:CHEBI:456216; EC=6.3.4.13; CC Evidence={ECO:0000256|ARBA:ARBA00001484, CC ECO:0000256|RuleBase:RU363089}; CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5- CC amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5- CC phospho-D-ribosyl)glycinamide: step 2/2. CC {ECO:0000256|ARBA:ARBA00004686, ECO:0000256|RuleBase:RU363089}. CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)- CC (5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1- CC diphosphate: step 2/2. {ECO:0000256|ARBA:ARBA00005174, CC ECO:0000256|RuleBase:RU363089}. CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)- CC formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D- CC ribosyl)glycinamide (10-formyl THF route): step 1/1. CC {ECO:0000256|ARBA:ARBA00005054, ECO:0000256|RuleBase:RU363089}. CC -!- SIMILARITY: In the C-terminal section; belongs to the GART family. CC {ECO:0000256|ARBA:ARBA00008630, ECO:0000256|RuleBase:RU363089}. CC -!- SIMILARITY: In the N-terminal section; belongs to the GARS family. CC {ECO:0000256|ARBA:ARBA00007423, ECO:0000256|RuleBase:RU363089}. CC -!- SIMILARITY: In the central section; belongs to the AIR synthase family. CC {ECO:0000256|ARBA:ARBA00008696, ECO:0000256|RuleBase:RU363089}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NXR57720.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VWYO01000865; NXR57720.1; -; Genomic_DNA. DR UniPathway; UPA00074; UER00125. DR Proteomes; UP000587697; Unassembled WGS sequence. DR CDD; cd08645; FMT_core_GART; 1. DR CDD; cd02196; PurM; 1. DR Gene3D; 3.30.1330.10; -; 1. DR Gene3D; 3.30.1490.20; -; 1. DR Gene3D; 3.90.600.10; -; 1. DR Gene3D; 3.90.650.10; -; 1. DR HAMAP; MF_00741; AIRS; 1. DR HAMAP; MF_00138; GARS; 1. DR HAMAP; MF_01930; PurN; 1. DR InterPro; IPR011761; ATP-grasp. DR InterPro; IPR013815; ATP_grasp_subdomain_1. DR InterPro; IPR002376; Formyl_transf_N. DR InterPro; IPR036477; Formyl_transf_N_sf. DR InterPro; IPR004607; GART. DR InterPro; IPR001555; GART_AS. DR InterPro; IPR016185; PreATP-grasp_dom_sf. DR InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp. DR InterPro; IPR000115; PRibGlycinamide_synth. DR InterPro; IPR020560; PRibGlycinamide_synth_C-dom. DR InterPro; IPR037123; PRibGlycinamide_synth_C_sf. DR InterPro; IPR020559; PRibGlycinamide_synth_CS. DR InterPro; IPR020562; PRibGlycinamide_synth_N. DR InterPro; IPR010918; PurM-like_C_dom. DR InterPro; IPR036676; PurM-like_C_sf. DR InterPro; IPR016188; PurM-like_N. DR InterPro; IPR036921; PurM-like_N_sf. DR InterPro; IPR004733; PurM_cligase. DR InterPro; IPR011054; Rudment_hybrid_motif. DR PANTHER; PTHR10520; PTHR10520; 1. DR Pfam; PF00586; AIRS; 1. DR Pfam; PF02769; AIRS_C; 1. DR Pfam; PF00551; Formyl_trans_N; 1. DR Pfam; PF01071; GARS_A; 1. DR Pfam; PF02843; GARS_C; 1. DR Pfam; PF02844; GARS_N; 1. DR SMART; SM01210; GARS_C; 1. DR SUPFAM; SSF51246; SSF51246; 1. DR SUPFAM; SSF52440; SSF52440; 1. DR SUPFAM; SSF53328; SSF53328; 1. DR SUPFAM; SSF55326; SSF55326; 1. DR SUPFAM; SSF56042; SSF56042; 1. DR TIGRFAMs; TIGR00877; purD; 1. DR TIGRFAMs; TIGR00878; purM; 1. DR TIGRFAMs; TIGR00639; PurN; 1. DR PROSITE; PS50975; ATP_GRASP; 1. DR PROSITE; PS00184; GARS; 1. DR PROSITE; PS00373; GART; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU00409}; KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363089}; KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|RuleBase:RU363089}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|RuleBase:RU363089}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268, KW ECO:0000256|RuleBase:RU363089}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU00409}; KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755, KW ECO:0000256|RuleBase:RU363089}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 113..320 FT /note="ATP-grasp" FT /evidence="ECO:0000259|PROSITE:PS50975" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NXR57720.1" FT NON_TER 1004 FT /evidence="ECO:0000313|EMBL:NXR57720.1" SQ SEQUENCE 1004 AA; 106889 MW; 4E03108F63D3A050 CRC64; RAMAERVLVI GSGGREHALA WKLAQSPHVK HVFVAPGNAG TADSGKISNS AVPVSDHAAV AQFCRDQDIR LVVVGPEAPL AAGIVDDLTA AGIRCFGPTA KAAQLESSKS FTKAFLDRHE IPTARWKSFT DPKAACAFIN SATFPALVVK ASGLAAGKGV IVASTKEEAC KAVTEIMQDK SFGTAGETVV VEELLEGEEI SCLCFSDGVT IAPMPPAQDH KRLMDGDEGP NTGGMGAYSP APQISKDLLQ KIRETVLQKT VDGMRKEGVP YLGVLYAGLM LTKDGPKVLE FNCRFGDPEC QVILPLLRSD LYEVMQAVIN RRLASSMPAW KEDSAAVTVV MASQGYPGAY PKGLEITGLA KAKQLGLEVF HAGTALKDGR VVTSGGRVLT VTAIKEDLPA ALREANLGVA AIHFQGAIYR RDIGYRAIAF LRQSRGLTYK NSGVDIEAGN TLVQKIKPFA AATSRSGCNA ELGGFAGLFD LKAAGYRDPI LVSGTDGVGT KLKIAQECQK HDTIGQDLVA MCVNDILAQG AEPLFFLDYF ACGKLDVEVA QGVIAGIADA CRKSGCALLG GETAEMPGMY PPGEYDLAGF AVGAVERGQM LPQLDRITEG DVVIGVASSG VHSNGFSLVR KIVEKSSLDF SSRVGVSGDQ TLGELLLTPT KLYSKSLLPV LRSGHVKAYA HITGGGLLEN IPRVLPDSCG VVLDALTWKI PEIFCWLHKE GNLSEEEMAR TFNCGVGAVL VVQKEMAQQV LKDIQAHESA WLIGKVVSLQ KGSDNVKVLN LHRALQANRS LCVHSHIQGK IQTGKVKVAV LISGTGTNLE ALINSTKKDT SYAQIVLVIS NKAGVEGLRK AERAGIPTRV VEHTRYPSRE EFDSAVDKVL EEFSVELICL AGFMRILSGP FVKKWEGKIL NIHPSLLPSF KGAHAHRLVL QAGVRVTGCT VHFVAEEVDA GAIIFQEAVP VKPGDTEATL AERVKEAEHR AFPAALQLVA SGAVRVGEAG KIYW //