ID A0A7L1UN52_PHANI Unreviewed; 173 AA. AC A0A7L1UN52; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 03-MAY-2023, entry version 9. DE RecName: Full=Cyclin-H {ECO:0000256|ARBA:ARBA00019496}; DE Flags: Fragment; GN Name=Ccnh {ECO:0000313|EMBL:NXO74311.1}; GN ORFNames=PHANIT_R07138 {ECO:0000313|EMBL:NXO74311.1}; OS Phainopepla nitens (Phainopepla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Bombycillidae; Phainopepla. OX NCBI_TaxID=161653 {ECO:0000313|EMBL:NXO74311.1, ECO:0000313|Proteomes:UP000579685}; RN [1] {ECO:0000313|EMBL:NXO74311.1, ECO:0000313|Proteomes:UP000579685} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B10K-DU-002-32 {ECO:0000313|EMBL:NXO74311.1}; RC TISSUE=Muscle {ECO:0000313|EMBL:NXO74311.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Regulates CDK7, the catalytic subunit of the CDK-activating CC kinase (CAK) enzymatic complex. CAK activates the cyclin-associated CC kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK CC complexed to the core-TFIIH basal transcription factor activates RNA CC polymerase II by serine phosphorylation of the repetitive C-terminal CC domain (CTD) of its large subunit (POLR2A), allowing its escape from CC the promoter and elongation of the transcripts. Involved in cell cycle CC control and in RNA transcription by RNA polymerase II. Its expression CC and activity are constant throughout the cell cycle. CC {ECO:0000256|ARBA:ARBA00025343}. CC -!- SUBUNIT: Associates primarily with CDK7 and MAT1 to form the CAK CC complex. CAK can further associate with the core-TFIIH to form the CC TFIIH basal transcription factor. {ECO:0000256|ARBA:ARBA00026042}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NXO74311.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VXBQ01017513; NXO74311.1; -; Genomic_DNA. DR AlphaFoldDB; A0A7L1UN52; -. DR Proteomes; UP000579685; Unassembled WGS sequence. DR GO; GO:0070985; C:transcription factor TFIIK complex; IEA:InterPro. DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro. DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro. DR CDD; cd20524; CYCLIN_CCNH_rpt1; 1. DR CDD; cd20525; CYCLIN_CCNH_rpt2; 1. DR Gene3D; 1.10.472.10; Cyclin-like; 2. DR InterPro; IPR036915; Cyclin-like_sf. DR InterPro; IPR043198; Cyclin/Ssn8. DR InterPro; IPR031658; Cyclin_C_2. DR InterPro; IPR006671; Cyclin_N. DR InterPro; IPR027081; CyclinH/Ccl1. DR PANTHER; PTHR10026; CYCLIN; 1. DR PANTHER; PTHR10026:SF8; CYCLIN-H; 1. DR Pfam; PF16899; Cyclin_C_2; 1. DR Pfam; PF00134; Cyclin_N; 1. DR SUPFAM; SSF47954; Cyclin-like; 2. DR TIGRFAMs; TIGR00569; ccl1; 1. PE 4: Predicted; KW Reference proteome {ECO:0000313|Proteomes:UP000579685}. FT DOMAIN 2..78 FT /note="Cyclin N-terminal" FT /evidence="ECO:0000259|Pfam:PF00134" FT DOMAIN 82..163 FT /note="Cyclin C-terminal" FT /evidence="ECO:0000259|Pfam:PF16899" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NXO74311.1" FT NON_TER 173 FT /evidence="ECO:0000313|EMBL:NXO74311.1" SQ SEQUENCE 173 AA; 19867 MW; 468A1D737F90D5DC CRC64; GTACMYFKRF YLNNSVMEYH PRIIMLTCAF LACKVDEFNV SSAQFVGNLR ESPVGQEKAL EQILEYELLL IQQLNFHLII HNPYRPFEGF LIDIKTRYPV LENPEVLRKT ADDFLNRVAL TDAYLLFTPS QIALTAILSS GSRAGINMES YLSESLMLKE NRSSLSRLLD DMK //