ID   A0A7L1UN52_PHANI        Unreviewed;       173 AA.
AC   A0A7L1UN52;
DT   07-APR-2021, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 1.
DT   24-JAN-2024, entry version 11.
DE   RecName: Full=Cyclin-H {ECO:0000256|ARBA:ARBA00019496};
DE   Flags: Fragment;
GN   Name=Ccnh {ECO:0000313|EMBL:NXO74311.1};
GN   ORFNames=PHANIT_R07138 {ECO:0000313|EMBL:NXO74311.1};
OS   Phainopepla nitens (Phainopepla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Bombycillidae; Phainopepla.
OX   NCBI_TaxID=161653 {ECO:0000313|EMBL:NXO74311.1, ECO:0000313|Proteomes:UP000579685};
RN   [1] {ECO:0000313|EMBL:NXO74311.1, ECO:0000313|Proteomes:UP000579685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B10K-DU-002-32 {ECO:0000313|EMBL:NXO74311.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:NXO74311.1};
RA   Zhang G.;
RT   "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates CDK7, the catalytic subunit of the CDK-activating
CC       kinase (CAK) enzymatic complex. CAK activates the cyclin-associated
CC       kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK
CC       complexed to the core-TFIIH basal transcription factor activates RNA
CC       polymerase II by serine phosphorylation of the repetitive C-terminal
CC       domain (CTD) of its large subunit (POLR2A), allowing its escape from
CC       the promoter and elongation of the transcripts. Involved in cell cycle
CC       control and in RNA transcription by RNA polymerase II. Its expression
CC       and activity are constant throughout the cell cycle.
CC       {ECO:0000256|ARBA:ARBA00025343}.
CC   -!- SUBUNIT: Associates primarily with CDK7 and MAT1 to form the CAK
CC       complex. CAK can further associate with the core-TFIIH to form the
CC       TFIIH basal transcription factor. {ECO:0000256|ARBA:ARBA00026042}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000256|ARBA:ARBA00008638}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:NXO74311.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; VXBQ01017513; NXO74311.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A7L1UN52; -.
DR   Proteomes; UP000579685; Unassembled WGS sequence.
DR   GO; GO:0070985; C:transcription factor TFIIK complex; IEA:InterPro.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd20524; CYCLIN_CCNH_rpt1; 1.
DR   CDD; cd20525; CYCLIN_CCNH_rpt2; 1.
DR   Gene3D; 1.10.472.10; Cyclin-like; 2.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR031658; Cyclin_C_2.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR027081; CyclinH/Ccl1.
DR   NCBIfam; TIGR00569; ccl1; 1.
DR   PANTHER; PTHR10026; CYCLIN; 1.
DR   PANTHER; PTHR10026:SF8; CYCLIN-H; 1.
DR   Pfam; PF16899; Cyclin_C_2; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SUPFAM; SSF47954; Cyclin-like; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000579685}.
FT   DOMAIN          2..78
FT                   /note="Cyclin N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00134"
FT   DOMAIN          82..172
FT                   /note="Cyclin C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16899"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:NXO74311.1"
FT   NON_TER         173
FT                   /evidence="ECO:0000313|EMBL:NXO74311.1"
SQ   SEQUENCE   173 AA;  19867 MW;  468A1D737F90D5DC CRC64;
     GTACMYFKRF YLNNSVMEYH PRIIMLTCAF LACKVDEFNV SSAQFVGNLR ESPVGQEKAL
     EQILEYELLL IQQLNFHLII HNPYRPFEGF LIDIKTRYPV LENPEVLRKT ADDFLNRVAL
     TDAYLLFTPS QIALTAILSS GSRAGINMES YLSESLMLKE NRSSLSRLLD DMK
//