ID A0A7K9X6B4_9GRUI Unreviewed; 425 AA. AC A0A7K9X6B4; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 19-JAN-2022, entry version 4. DE RecName: Full=Hedgehog protein {ECO:0000256|RuleBase:RU280812}; DE Flags: Fragment; GN Name=Shh {ECO:0000313|EMBL:NXI92852.1}; GN ORFNames=PSOCRE_R04203 {ECO:0000313|EMBL:NXI92852.1}; OS Psophia crepitans (common trumpeter). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Psophiidae; Psophia. OX NCBI_TaxID=54359 {ECO:0000313|EMBL:NXI92852.1, ECO:0000313|Proteomes:UP000587472}; RN [1] {ECO:0000313|EMBL:NXI92852.1, ECO:0000313|Proteomes:UP000587472} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B10K-DU-001-60 {ECO:0000313|EMBL:NXI92852.1}; RC TISSUE=Muscle {ECO:0000313|EMBL:NXI92852.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Intercellular signal essential for a variety of patterning CC events during development. {ECO:0000256|RuleBase:RU280812}. CC -!- SIMILARITY: Belongs to the hedgehog family. CC {ECO:0000256|ARBA:ARBA00010649, ECO:0000256|RuleBase:RU280812}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NXI92852.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VWZZ01002220; NXI92852.1; -; Genomic_DNA. DR Proteomes; UP000587472; Unassembled WGS sequence. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0007267; P:cell-cell signaling; IEA:InterPro. DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro. DR GO; GO:0016540; P:protein autoprocessing; IEA:InterPro. DR GO; GO:0048731; P:system development; IEA:UniProt. DR Gene3D; 3.30.1380.10; -; 1. DR InterPro; IPR001657; Hedgehog. DR InterPro; IPR001767; Hedgehog_Hint. DR InterPro; IPR009045; Hedgehog_sig/DD-Pept_Zn-bd_sf. DR InterPro; IPR000320; Hedgehog_signalling_dom. DR InterPro; IPR003586; Hint_dom_C. DR InterPro; IPR003587; Hint_dom_N. DR InterPro; IPR036844; Hint_dom_sf. DR InterPro; IPR006141; Intein_N. DR Pfam; PF01085; HH_signal; 1. DR Pfam; PF01079; Hint; 1. DR PIRSF; PIRSF009400; Peptidase_C46; 1. DR PRINTS; PR00632; SONICHHOG. DR SMART; SM00305; HintC; 1. DR SMART; SM00306; HintN; 1. DR SUPFAM; SSF51294; SSF51294; 1. DR SUPFAM; SSF55166; SSF55166; 1. DR PROSITE; PS50817; INTEIN_N_TER; 1. PE 3: Inferred from homology; KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813, KW ECO:0000256|RuleBase:RU280812}; KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR009400-2}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, KW ECO:0000256|RuleBase:RU280812}; KW Developmental protein {ECO:0000256|ARBA:ARBA00022473, KW ECO:0000256|RuleBase:RU280812}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU280812}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280812}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|PIRSR:PIRSR009400-2}; KW Palmitate {ECO:0000256|ARBA:ARBA00023139}; KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU280812}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280812}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR009400-2}. FT SIGNAL 1..26 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 27..425 FT /note="Hedgehog protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5029675991" FT DOMAIN 199..309 FT /note="HintN" FT /evidence="ECO:0000259|SMART:SM00306" FT DOMAIN 312..357 FT /note="HintC" FT /evidence="ECO:0000259|SMART:SM00305" FT METAL 92 FT /note="Calcium 1" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-2" FT METAL 93 FT /note="Calcium 1" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-2" FT METAL 93 FT /note="Calcium 2" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-2" FT METAL 98 FT /note="Calcium 1" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-2" FT METAL 128 FT /note="Calcium 1; via carbonyl oxygen" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-2" FT METAL 129 FT /note="Calcium 1" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-2" FT METAL 129 FT /note="Calcium 2" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-2" FT METAL 132 FT /note="Calcium 2" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-2" FT METAL 134 FT /note="Calcium 2" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-2" FT METAL 143 FT /note="Zinc" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-2" FT METAL 150 FT /note="Zinc" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-2" FT METAL 185 FT /note="Zinc" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-2" FT SITE 200..201 FT /note="Cleavage; by autolysis" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-1" FT SITE 246 FT /note="Involved in cholesterol transfer" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-1" FT SITE 270 FT /note="Involved in auto-cleavage" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-1" FT SITE 273 FT /note="Essential for auto-cleavage" FT /evidence="ECO:0000256|PIRSR:PIRSR009400-1" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NXI92852.1" FT NON_TER 425 FT /evidence="ECO:0000313|EMBL:NXI92852.1" SQ SEQUENCE 425 AA; 46572 MW; AF755EAA68F51E94 CRC64; MDEMLLLTRI LLVGFICALL VSSGLTCGPG RGIGKRRHPK KLTPLAYKQF IPNVAEKTLG ASGRYEGKIT RNSERFKELT PNYNPDIIFK DEENTGADRL MTQRCKDKLN ALAISVMNQW PGVKLRVTEG WDEDGHHSEE ALHYEGRAVD ITTSDRDRSK YGMLARLAVE AGFDWVYYES KAHIHCSVKA ENSVAAKSGG CFPGSATVHL EQGGTKLVKD LSPGDRVLAA DAEGRLLYSD FLAFLDREDG SHKLFYVIET RQPRARLLLT AAHLVFVAPQ HNQSQEGTPS SRALFASHIR PGQRVYVLGE GGQQLLPAAV HSVSLREEAS GAYAPLTAQG TILINRVLAS CYAVIEEHSW AHWAFAPFRL LQGMLAALCP SAGGVPVGAP ADSGIHWYSR LLYRIGSWVL DSDSLHPLGM VVPSS //