ID   A0A7K9X6B4_9GRUI        Unreviewed;       425 AA.
AC   A0A7K9X6B4;
DT   07-APR-2021, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 1.
DT   02-JUN-2021, entry version 2.
DE   RecName: Full=Hedgehog protein {ECO:0000256|RuleBase:RU280812};
DE   Flags: Fragment;
GN   Name=Shh {ECO:0000313|EMBL:NXI92852.1};
GN   ORFNames=PSOCRE_R04203 {ECO:0000313|EMBL:NXI92852.1};
OS   Psophia crepitans (common trumpeter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Gruiformes; Psophiidae; Psophia.
OX   NCBI_TaxID=54359 {ECO:0000313|EMBL:NXI92852.1, ECO:0000313|Proteomes:UP000587472};
RN   [1] {ECO:0000313|EMBL:NXI92852.1, ECO:0000313|Proteomes:UP000587472}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B10K-DU-001-60 {ECO:0000313|EMBL:NXI92852.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:NXI92852.1};
RA   Zhang G.;
RT   "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Intercellular signal essential for a variety of patterning
CC       events during development. {ECO:0000256|RuleBase:RU280812}.
CC   -!- SIMILARITY: Belongs to the hedgehog family.
CC       {ECO:0000256|ARBA:ARBA00010649, ECO:0000256|RuleBase:RU280812}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:NXI92852.1}.
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DR   EMBL; VWZZ01002220; NXI92852.1; -; Genomic_DNA.
DR   Proteomes; UP000587472; Unassembled WGS sequence.
DR   Gene3D; 3.30.1380.10; -; 1.
DR   InterPro; IPR001657; Hedgehog.
DR   InterPro; IPR001767; Hedgehog_Hint.
DR   InterPro; IPR009045; Hedgehog_sig/DD-Pept_Zn-bd_sf.
DR   InterPro; IPR000320; Hedgehog_signalling_dom.
DR   InterPro; IPR003586; Hint_dom_C.
DR   InterPro; IPR003587; Hint_dom_N.
DR   InterPro; IPR036844; Hint_dom_sf.
DR   InterPro; IPR006141; Intein_N.
DR   Pfam; PF01085; HH_signal; 1.
DR   Pfam; PF01079; Hint; 1.
DR   PIRSF; PIRSF009400; Peptidase_C46; 1.
DR   PRINTS; PR00632; SONICHHOG.
DR   SMART; SM00305; HintC; 1.
DR   SMART; SM00306; HintN; 1.
DR   SUPFAM; SSF51294; SSF51294; 1.
DR   SUPFAM; SSF55166; SSF55166; 1.
DR   PROSITE; PS50817; INTEIN_N_TER; 1.
PE   3: Inferred from homology;
KW   Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813,
KW   ECO:0000256|RuleBase:RU280812}; Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU280812};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|RuleBase:RU280812};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU280812};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280812};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU280812};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280812}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..425
FT                   /note="Hedgehog protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5029675991"
FT   DOMAIN          199..309
FT                   /note="HintN"
FT                   /evidence="ECO:0000259|SMART:SM00306"
FT   DOMAIN          312..357
FT                   /note="HintC"
FT                   /evidence="ECO:0000259|SMART:SM00305"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:NXI92852.1"
FT   NON_TER         425
FT                   /evidence="ECO:0000313|EMBL:NXI92852.1"
SQ   SEQUENCE   425 AA;  46572 MW;  AF755EAA68F51E94 CRC64;
     MDEMLLLTRI LLVGFICALL VSSGLTCGPG RGIGKRRHPK KLTPLAYKQF IPNVAEKTLG
     ASGRYEGKIT RNSERFKELT PNYNPDIIFK DEENTGADRL MTQRCKDKLN ALAISVMNQW
     PGVKLRVTEG WDEDGHHSEE ALHYEGRAVD ITTSDRDRSK YGMLARLAVE AGFDWVYYES
     KAHIHCSVKA ENSVAAKSGG CFPGSATVHL EQGGTKLVKD LSPGDRVLAA DAEGRLLYSD
     FLAFLDREDG SHKLFYVIET RQPRARLLLT AAHLVFVAPQ HNQSQEGTPS SRALFASHIR
     PGQRVYVLGE GGQQLLPAAV HSVSLREEAS GAYAPLTAQG TILINRVLAS CYAVIEEHSW
     AHWAFAPFRL LQGMLAALCP SAGGVPVGAP ADSGIHWYSR LLYRIGSWVL DSDSLHPLGM
     VVPSS
//