ID A0A7K9EYS2_STEPR Unreviewed; 760 AA. AC A0A7K9EYS2; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 03-MAY-2023, entry version 10. DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221}; DE Flags: Fragment; GN Name=Clcn4 {ECO:0000313|EMBL:NXG81739.1}; GN ORFNames=STEPAR_R14140 {ECO:0000313|EMBL:NXG81739.1}; OS Stercorarius parasiticus (Parasitic jaeger) (Arctic skua). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Charadriiformes; Stercorariidae; OC Stercorarius. OX NCBI_TaxID=54059 {ECO:0000313|EMBL:NXG81739.1, ECO:0000313|Proteomes:UP000532908}; RN [1] {ECO:0000313|EMBL:NXG81739.1, ECO:0000313|Proteomes:UP000532908} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B10K-DU-001-20 {ECO:0000313|EMBL:NXG81739.1}; RC TISSUE=Muscle {ECO:0000313|EMBL:NXG81739.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141, CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}. CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. CC {ECO:0000256|RuleBase:RU361221}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NXG81739.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VWZL01000222; NXG81739.1; -; Genomic_DNA. DR AlphaFoldDB; A0A7K9EYS2; -. DR Proteomes; UP000532908; Unassembled WGS sequence. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule. DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1. DR CDD; cd03684; ClC_3_like; 1. DR Gene3D; 3.10.580.20; -; 1. DR Gene3D; 3.90.1280.20; -; 1. DR Gene3D; 1.10.3080.10; Clc chloride channel; 1. DR InterPro; IPR000644; CBS_dom. DR InterPro; IPR046342; CBS_dom_sf. DR InterPro; IPR014743; Cl-channel_core. DR InterPro; IPR001807; Cl-channel_volt-gated. DR InterPro; IPR002246; Cl_channel-4. DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1. DR PANTHER; PTHR45711:SF2; H(+)/CL(-) EXCHANGE TRANSPORTER 4; 1. DR Pfam; PF00571; CBS; 2. DR Pfam; PF00654; Voltage_CLC; 1. DR PRINTS; PR00762; CLCHANNEL. DR PRINTS; PR01115; CLCHANNEL4. DR SMART; SM00116; CBS; 2. DR SUPFAM; SSF54631; CBS-domain pair; 1. DR SUPFAM; SSF81340; Clc chloride channel; 1. DR PROSITE; PS51371; CBS; 2. PE 3: Inferred from homology; KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE- KW ProRule:PRU00703}; Chloride {ECO:0000256|RuleBase:RU361221}; KW Ion transport {ECO:0000256|RuleBase:RU361221}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221}; KW Reference proteome {ECO:0000313|Proteomes:UP000532908}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU361221}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}. FT TRANSMEM 68..92 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 153..175 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 195..215 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 227..243 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 255..279 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 332..356 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 368..385 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 441..461 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 468..487 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 515..540 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT DOMAIN 600..664 FT /note="CBS" FT /evidence="ECO:0000259|PROSITE:PS51371" FT DOMAIN 697..755 FT /note="CBS" FT /evidence="ECO:0000259|PROSITE:PS51371" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NXG81739.1" FT NON_TER 760 FT /evidence="ECO:0000313|EMBL:NXG81739.1" SQ SEQUENCE 760 AA; 84927 MW; 7021B696F7502D68 CRC64; MVNAGDMNGS GNLMDFLDEP FPDVGTYEDF HTIDWLREKS RDTDRHRKIT SKSKESIWEF IKSLLDAWSG WVVMLLIGLL AGTLAGVIDL AVDWMTDLKE GVCLSAFWYS HEQCCWTSNE TTFDDRDKCP LWQKWSELLV SQSEGASAYI LNYFLYIMWA LCFAFLAVSL VRVFAPYACG SGIPEIKTIL SGFIIRGYLG KWTLLIKTVT LVLVVSSGLS LGKEGPLVHV ACCCGNFFSS LFSKYSKNEG KRREVLSAAA AAGVSVAFGA PIGGVLFSLE EVSYYFPLKT LWRSFFAALV AAFTLRSINP FGNSRLVLFY VEYHTPWYMA ELFPFILLGV FGGLWGTLFI RCNIAWCRRR KTTRLGKYPV LEVIVITAIT AIIAYPNPYT RRSTSELISE LFNDCGALES SQLCDYINDP NMTRPVDDIP DRPAGPGVYT AMWQLALALV FKIVITIFTF GMKIPSGLFI PSMAVGAMAG RMVGIGVEQL AYHHHDWIIF RNWCRPGADC VTPGLYAMVG AAACLGGVTR MTVSLVVIMF ELTGGLEYIV PLMAAAVTSK WVADAFGKEG IYEAHIHLNG YPFLDVKDEF THRTLATDVM RPRRGEAPLS VLTQDSMTVE DVETLIKETD YNGFPVVVSK DSERLIGFAQ RRELILAIKN ARQRQDGVVS NSIVYFTEDP PELPPNSPHP LKLRRILNLS PFTVTDHTPM ETVVDIFRKL GLRQCLVTRS GRLLGIITKK DVLRHMAQMA NQDPESIMFN //