ID A0A7K7ZIT9_9PASE Unreviewed; 715 AA. AC A0A7K7ZIT9; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 02-OCT-2024, entry version 12. DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365}; DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728}; DE Flags: Fragment; GN Name=Mpeg1 {ECO:0000313|EMBL:NXA89158.1}; GN ORFNames=MELVER_R01450 {ECO:0000313|EMBL:NXA89158.1}; OS Melanocharis versteri (Fan-tailed berrypecker). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Melanocharitidae; Melanocharis. OX NCBI_TaxID=254552 {ECO:0000313|EMBL:NXA89158.1, ECO:0000313|Proteomes:UP000538725}; RN [1] {ECO:0000313|EMBL:NXA89158.1, ECO:0000313|Proteomes:UP000538725} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B10K-DU-029-37 {ECO:0000313|EMBL:NXA89158.1}; RC TISSUE=Liver {ECO:0000313|EMBL:NXA89158.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane CC {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004439}. Cytoplasmic vesicle, phagosome CC membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004265}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the MPEG1 family. CC {ECO:0000256|ARBA:ARBA00007256}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NXA89158.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VZTG01003302; NXA89158.1; -; Genomic_DNA. DR AlphaFoldDB; A0A7K7ZIT9; -. DR Proteomes; UP000538725; Unassembled WGS sequence. DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR CDD; cd22579; MPEG1_P2; 1. DR InterPro; IPR020864; MACPF. DR InterPro; IPR039707; MPEG1. DR PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1. DR PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1. DR Pfam; PF01823; MACPF; 1. DR SMART; SM00457; MACPF; 1. DR PROSITE; PS51412; MACPF_2; 1. PE 3: Inferred from homology; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130}; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00023130}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000538725}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}. FT SIGNAL 1..21 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 22..715 FT /note="Macrophage-expressed gene 1 protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5029859621" FT TRANSMEM 653..674 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 32..347 FT /note="MACPF" FT /evidence="ECO:0000259|PROSITE:PS51412" FT REGION 688..715 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NXA89158.1" FT NON_TER 715 FT /evidence="ECO:0000313|EMBL:NXA89158.1" SQ SEQUENCE 715 AA; 77548 MW; 93383E72C06D1937 CRC64; MGWGLWGVLF TWALLAWVTG AGPSQELSSS SGFGACSKTL KLSRLEVLPG GGWDNLRNLD MGRVINLGYS QCKTTEDGSY LIPDEIFTIP RKQSNLDINS EIIESWKDYQ SITSASINLE LSLFSSINGK FSSDFHRTKT HHVRDQAVTT RVQVRNLVYT AKIDPEAALD KAFKEQLLTI ASHLENNQTQ MADFLAEVLV LNYGTHTITS VDAGATLVQE DQIKATFLKD SWATRSAVTA SAGVAFHSIV SVGTKESLDI SSGFAKQYLE NRTNSRVESI GGTPFYPGIT LKTWQERIQN QLVALDRSGL PLYYFIKPST VPELPAPTVH RVARRVELAI RRYYTFNTAP GCTDASSPNF NFHANTDDGS CKGTMANFTF AGVFQECVGL AGPDTDALCR ALEQRNPLTG AFSCPATYTP VLLGVQEREE GHSHLECHNK CTLGIFCHRK CQDVFWLSRV QFSAYWCAAS GPVAPNSGYL FGGLFSTHSA NPITGAQSCP SGYFPLKLFG ELRVCVSQDY EGGAKYAVPF GGFFSCQAGN PLAGHHQGTA EDPHAKRCPP GFSQHLALIS DSCQVQFCVQ AGLLTGGSLP PARLPPFTRP PANLPAVDTL LVRDGDSTWV RDGQSHVWRL ARPEEVQHVA EMVRGRGLSG GEVAGVTAAV LVGLATGLGT AWYGHRRYRA RGYRTLGTGD SPAPASPEHS TVLSVGEGYQ QEAEG //