ID A0A7K7I9U6_LOXCU Unreviewed; 718 AA. AC A0A7K7I9U6; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 29-SEP-2021, entry version 3. DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365}; DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00022321}; DE Flags: Fragment; GN Name=Mpeg1 {ECO:0000313|EMBL:NWY90836.1}; GN ORFNames=LOXCUR_R05392 {ECO:0000313|EMBL:NWY90836.1}; OS Loxia curvirostra (Red crossbill). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Fringillidae; OC Carduelinae; Loxia. OX NCBI_TaxID=64802 {ECO:0000313|EMBL:NWY90836.1, ECO:0000313|Proteomes:UP000564784}; RN [1] {ECO:0000313|EMBL:NWY90836.1, ECO:0000313|Proteomes:UP000564784} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=OUT-0011 {ECO:0000313|EMBL:NWY90836.1}; RC TISSUE=Muscle {ECO:0000313|EMBL:NWY90836.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane CC {ECO:0000256|ARBA:ARBA00004358}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004358}. Membrane CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the MPEG1 family. CC {ECO:0000256|ARBA:ARBA00007256}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NWY90836.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VZSM01000693; NWY90836.1; -; Genomic_DNA. DR Proteomes; UP000564784; Unassembled WGS sequence. DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR InterPro; IPR020864; MACPF. DR InterPro; IPR039707; MPEG1. DR PANTHER; PTHR31463; PTHR31463; 1. DR Pfam; PF01823; MACPF; 1. DR SMART; SM00457; MACPF; 1. DR PROSITE; PS51412; MACPF_2; 1. PE 3: Inferred from homology; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000564784}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}. FT SIGNAL 1..21 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 22..718 FT /note="Macrophage-expressed gene 1 protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5029841853" FT TRANSMEM 653..674 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 32..347 FT /note="MACPF" FT /evidence="ECO:0000259|PROSITE:PS51412" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NWY90836.1" FT NON_TER 718 FT /evidence="ECO:0000313|EMBL:NWY90836.1" SQ SEQUENCE 718 AA; 77544 MW; 4AC40AC63652675E CRC64; MGWGLRGASL TWALLAWVTG AEQPQELSSS SGFGVCSKTL KLSRLEVLPG GGWDNLRNLD MGRVINLGYS QCKTTEDGSY LIPDEIFTIP RKQSNLDMNS EIIESWKDYQ SITSASINLE LSLFSSINGK FSSDFHRTKT QQVRDKAVTT RVQVRNLVYT AKIDPEAALD KAFKKQLLTI ASHLENNQTQ MADFLAEVLV LNYGTHTITS VDAGATLVQE DQIKATLLKD SWATRSTVTA SAGVAFHSIV NVGTKESLDV SSGFTKQYLD NRTSSRVESI GGTPFYPGIT LKTWQEGIQN QLVALDRSGL PLYYFIKPSA LPELPVPTVR RVARHVELAI RRYYTFNTAP GCTNASSPNF NFHANTDDGS CEGTVANFTF GGVFQECVGL GGPDTGALCR ALEQRNPLTG AFSCPTAYTP VLLGVQEREE GHSHLECHNK CTLGIFCHRK CQDVFWLSRV QFSAYWCAAS GPVAPNSGYL FGGLFSTHGA NPITRAPSCP SGFFPLKLFG ELRVCVSQDY EAGAEYAVPF GGFFSCQAGN PLAGKHQGGA EDAHAKGCPS GFSQHLALIS DSCQVQFCIR AGLLTGGSLP PARLPPFTRP PANLPAVETL LVRDGDSTWV RDGQSHVWRL ARPEEAQRAA EMVGTRGLSG GEVAGVTVAV LAGLATGLGT AWYGHRRYRA KGYHELGTGD SPAPASPEHS TVLSVGEGYQ QEVEGMMP //