ID A0A7K7CZV0_PHEME Unreviewed; 225 AA. AC A0A7K7CZV0; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 25-MAY-2022, entry version 5. DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113}; DE Flags: Fragment; GN Name=Insig2 {ECO:0000313|EMBL:NWY26364.1}; GN ORFNames=PHEMEL_R00771 {ECO:0000313|EMBL:NWY26364.1}; OS Pheucticus melanocephalus (Black-headed grosbeak) (Guiraca melanocephala). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Fringillidae; OC Emberizinae; Cardinalini; Pheucticus. OX NCBI_TaxID=371919 {ECO:0000313|EMBL:NWY26364.1, ECO:0000313|Proteomes:UP000578259}; RN [1] {ECO:0000313|EMBL:NWY26364.1, ECO:0000313|Proteomes:UP000578259} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=OUT-0018 {ECO:0000313|EMBL:NWY26364.1}; RC TISSUE=Muscle {ECO:0000313|EMBL:NWY26364.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis. CC {ECO:0000256|RuleBase:RU241113}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU241113}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477, CC ECO:0000256|RuleBase:RU241113}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the INSIG family. CC {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NWY26364.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VZSJ01000775; NWY26364.1; -; Genomic_DNA. DR Proteomes; UP000578259; Unassembled WGS sequence. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR025929; INSIG_fam. DR PANTHER; PTHR15301; PTHR15301; 1. DR Pfam; PF07281; INSIG; 1. PE 3: Inferred from homology; KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548, KW ECO:0000256|RuleBase:RU241113}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824, KW ECO:0000256|RuleBase:RU241113}; KW Lipid metabolism {ECO:0000256|RuleBase:RU241113}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113}; KW Reference proteome {ECO:0000313|Proteomes:UP000578259}; KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221, KW ECO:0000256|RuleBase:RU241113}; KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU241113}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 28..49 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 69..88 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 131..148 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 155..174 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 186..206 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NWY26364.1" FT NON_TER 225 FT /evidence="ECO:0000313|EMBL:NWY26364.1" SQ SEQUENCE 225 AA; 24852 MW; 16B36C921279819B CRC64; MAENDAMPTI PKKCGPYISS VTSRGMNLVI RGVVLFFIGV FLALVLNLLQ IQRNVTLFPP DVITSIFSSA WWVPPCCGTA SAVIGLLYPC MDRHLGEPHK FKREWSSVMR CVAVFVGINH ASAKVDFANN IQLSLTLAAL SIGLWWTFDR SRSGFGLGVG IAFLATLVSQ LLVYNGVYQY TSPDFLYVRS WLPCIFFAGG ITMGNIGRQL AMYECKVIAE KSHED //