ID A0A7K7AI15_9AVES Unreviewed; 299 AA. AC A0A7K7AI15; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 27-MAR-2024, entry version 11. DE RecName: Full=mitogen-activated protein kinase kinase {ECO:0000256|ARBA:ARBA00038999}; DE EC=2.7.12.2 {ECO:0000256|ARBA:ARBA00038999}; DE Flags: Fragment; GN Name=Map2k3 {ECO:0000313|EMBL:NWX95517.1}; GN ORFNames=NOTORN_R08873 {ECO:0000313|EMBL:NWX95517.1}; OS Nothoprocta ornata. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Palaeognathae; Tinamiformes; Tinamidae; Nothoprocta. OX NCBI_TaxID=83376 {ECO:0000313|EMBL:NWX95517.1, ECO:0000313|Proteomes:UP000531938}; RN [1] {ECO:0000313|EMBL:NWX95517.1, ECO:0000313|Proteomes:UP000531938} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B10K-MSB-03 {ECO:0000313|EMBL:NWX95517.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; CC Evidence={ECO:0000256|ARBA:ARBA00036883}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; CC EC=2.7.12.2; Evidence={ECO:0000256|ARBA:ARBA00036524}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2; CC Evidence={ECO:0000256|ARBA:ARBA00035978}; CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr CC protein kinase family. MAP kinase kinase subfamily. CC {ECO:0000256|ARBA:ARBA00038035}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NWX95517.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VZSH01000004; NWX95517.1; -; Genomic_DNA. DR AlphaFoldDB; A0A7K7AI15; -. DR Proteomes; UP000531938; Unassembled WGS sequence. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. DR GO; GO:0000165; P:MAPK cascade; IEA:UniProt. DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW. DR CDD; cd06617; PKc_MKK3_6; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR PANTHER; PTHR48013:SF21; DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3; 1. DR PANTHER; PTHR48013; DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED; 1. DR Pfam; PF00069; Pkinase; 1. DR PIRSF; PIRSF000654; Integrin-linked_kinase; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:NWX95517.1}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000531938}; KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304}; KW Transferase {ECO:0000313|EMBL:NWX95517.1}. FT DOMAIN 16..277 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT BINDING 45 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NWX95517.1" FT NON_TER 299 FT /evidence="ECO:0000313|EMBL:NWX95517.1" SQ SEQUENCE 299 AA; 34088 MW; F862EF28E7956CC6 CRC64; ILSLSVQNFE VEADDLVTIS ELGRGAYGVV EKVRHAQSGT IMAVKRIRAT VNTQEQKRLL MDLDISMRTV DCFYTVTFYG ALFREGDVWI CMELMDTSLD KFYKKVLEKK KTIPEDILGK MAVSIVRALE HLHSKLSVIH RDVKPSNVLI NKEGHVKMCD FGISGYLVDS VAKTMDAGCK PYMAPERINP ELNQKGYNVK SDVWSLGITM IELAILRFPY ESWGTPFQQL KQVVEEPSPQ LPADRFSKEF VDFTAQCLRK NPAERMNYLE LMEHPFFTLH DTKETDMASF VTEILGEDS //