ID A0A7K6UEG3_9AVES Unreviewed; 981 AA. AC A0A7K6UEG3; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 03-MAY-2023, entry version 8. DE RecName: Full=Nuclear factor NF-kappa-B p105 subunit {ECO:0000256|ARBA:ARBA00020838}; DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 {ECO:0000256|ARBA:ARBA00032626}; DE Flags: Fragment; GN Name=Nfkb1 {ECO:0000313|EMBL:NWX21242.1}; GN ORFNames=AEGBEN_R08556 {ECO:0000313|EMBL:NWX21242.1}; OS Aegotheles bennettii. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Caprimulgiformes; OC Aegothelidae; Aegotheles. OX NCBI_TaxID=48278 {ECO:0000313|EMBL:NWX21242.1, ECO:0000313|Proteomes:UP000559068}; RN [1] {ECO:0000313|EMBL:NWX21242.1, ECO:0000313|Proteomes:UP000559068} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B10K-DU-029-76 {ECO:0000313|EMBL:NWX21242.1}; RC TISSUE=Heart {ECO:0000313|EMBL:NWX21242.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NWX21242.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VZRW01010342; NWX21242.1; -; Genomic_DNA. DR AlphaFoldDB; A0A7K6UEG3; -. DR Proteomes; UP000559068; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR CDD; cd08797; Death_NFkB1_p105; 1. DR CDD; cd01177; IPT_NFkappaB; 1. DR CDD; cd07935; RHD-n_NFkB1; 1. DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1. DR Gene3D; 1.10.533.10; Death Domain, Fas; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR InterPro; IPR011029; DEATH-like_dom_sf. DR InterPro; IPR000488; Death_domain. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR014756; Ig_E-set. DR InterPro; IPR002909; IPT_dom. DR InterPro; IPR033926; IPT_NFkappaB. DR InterPro; IPR047096; NF-kB_p105_DD. DR InterPro; IPR030503; NF-kB_p105_RHD_N. DR InterPro; IPR000451; NFkB/Dor. DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf. DR InterPro; IPR030492; RHD_CS. DR InterPro; IPR032397; RHD_dimer. DR InterPro; IPR011539; RHD_DNA_bind_dom. DR InterPro; IPR037059; RHD_DNA_bind_dom_sf. DR PANTHER; PTHR24169:SF9; NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT; 1. DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1. DR Pfam; PF12796; Ank_2; 2. DR Pfam; PF00531; Death; 1. DR Pfam; PF16179; RHD_dimer; 1. DR Pfam; PF00554; RHD_DNA_bind; 1. DR PRINTS; PR00057; NFKBTNSCPFCT. DR SMART; SM00248; ANK; 7. DR SMART; SM00005; DEATH; 1. DR SMART; SM00429; IPT; 1. DR SUPFAM; SSF48403; Ankyrin repeat; 1. DR SUPFAM; SSF47986; DEATH domain; 1. DR SUPFAM; SSF81296; E set domains; 1. DR SUPFAM; SSF49417; p53-like transcription factors; 1. DR PROSITE; PS50297; ANK_REP_REGION; 6. DR PROSITE; PS50088; ANK_REPEAT; 6. DR PROSITE; PS01204; REL_1; 1. DR PROSITE; PS50254; REL_2; 1. PE 4: Predicted; KW Activator {ECO:0000256|ARBA:ARBA00023159}; KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE- KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Reference proteome {ECO:0000313|Proteomes:UP000559068}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}. FT DOMAIN 44..251 FT /note="RHD" FT /evidence="ECO:0000259|PROSITE:PS50254" FT REPEAT 539..571 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 578..610 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 611..634 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 647..679 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 681..714 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 715..747 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REGION 423..451 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 426..442 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NWX21242.1" FT NON_TER 981 FT /evidence="ECO:0000313|EMBL:NWX21242.1" SQ SEQUENCE 981 AA; 107753 MW; FFA60F94574E0135 CRC64; MAGEDSYIMG VSDPQMFAMD QLMGMNALFN NTNYITSDLP LRTADGPYLQ IIEQPKQRGF RFRYVCEGPS HGGLPGASSE KNKKSYPQVK ICNYVGPAKV IVQLVTNGKY VHLHAHSLVG KFCEDGVCTV NAGPKDMVVG FANLGILHVT KKKVFETLET RMIDACKKGY NPGLLVHPEL AYLQAEGSGD RQLTEREREI IRQAAVQQTK EMDLSVVRLM FTAFLPDSNG SFTRKLDPVI SDAIYDSKAP NASNLKIVRM DRTAGCVTGG EEIYLLCDKV QKDDIQIRFY EEDENGGMWE GFGDFSPTDV HRQFAIVFKT PKYRDVNITK PASVFVQLRR KSDLETSEPK PFLYYPEIKD KEEVQRKRQK LMPNFSDGYG GGSGAGGGGM YGGGGSGAGS GFSYPSYGYS AFGGMHFHPG TTKSNAGMKH GLSDSTAEQG GKSSDRQSDK WNMKYDVKVE TMERNECRTS GDNEQEEDAA SCKTEVNEAD CRWQDGPFLE KAMQLAKHHC NALFDYAVTG DVKMLLAVQR HLTVVQDDNG DNVLHLAIIH LHTELVKNLL EVMPDVNYDE IINMRNDLYQ TPLHLAVITK QAELVEDLLK AGADVSLLDR HGNSVLHLAA TEGDDKILSL LLKHKKISPL VDLSNGEGLS AIHMVVMANS MSCLKQLIAA GVNVNAQEQK SGRTALHLAV EQENIPLAGC LLLEGDADVD STTYDGTTPL HIAAARGSAK LAAVLKAAGA NPHVENFEPL FDLDDVKDDE YDDEGIVPGT TPLDMAANCE VYDILNGKPY ESAVVSEDLL TQGHLKELNE SSKRELYRLL EVPDPNKNWS TLAQKLGLGI LNNAFMLSPS PSKTLLDNYE VSGGTVQELI AALRQMDHTK AIEVIQKALC VSQSPSYKED NTAKVLPSSS PPTFANRDTG ELYNSKFQDN ESMCDSGVET SFRKLSFTYS DSLNSKSSVT LSKMTLGYGR ESSLQSNYIA N //