ID A0A7K6TQZ0_9AVES Unreviewed; 729 AA. AC A0A7K6TQZ0; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 13-SEP-2023, entry version 8. DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732}; DE Flags: Fragment; GN Name=Slc6a15 {ECO:0000313|EMBL:NWX12987.1}; GN ORFNames=AEGBEN_R04114 {ECO:0000313|EMBL:NWX12987.1}; OS Aegotheles bennettii. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Caprimulgiformes; OC Aegothelidae; Aegotheles. OX NCBI_TaxID=48278 {ECO:0000313|EMBL:NWX12987.1, ECO:0000313|Proteomes:UP000559068}; RN [1] {ECO:0000313|EMBL:NWX12987.1, ECO:0000313|Proteomes:UP000559068} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B10K-DU-029-76 {ECO:0000313|EMBL:NWX12987.1}; RC TISSUE=Heart {ECO:0000313|EMBL:NWX12987.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out); CC Xref=Rhea:RHEA:29283, ChEBI:CHEBI:29101, ChEBI:CHEBI:57972; CC Evidence={ECO:0000256|ARBA:ARBA00034289}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out); CC Xref=Rhea:RHEA:71383, ChEBI:CHEBI:29101, ChEBI:CHEBI:58048; CC Evidence={ECO:0000256|ARBA:ARBA00034241}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-cysteine(in) + Na(+)(in) = L-cysteine(out) + Na(+)(out); CC Xref=Rhea:RHEA:68232, ChEBI:CHEBI:29101, ChEBI:CHEBI:35235; CC Evidence={ECO:0000256|ARBA:ARBA00034279}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out); CC Xref=Rhea:RHEA:68236, ChEBI:CHEBI:29101, ChEBI:CHEBI:58359; CC Evidence={ECO:0000256|ARBA:ARBA00034242}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-isoleucine(in) + Na(+)(in) = L-isoleucine(out) + Na(+)(out); CC Xref=Rhea:RHEA:29275, ChEBI:CHEBI:29101, ChEBI:CHEBI:58045; CC Evidence={ECO:0000256|ARBA:ARBA00034260}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out); CC Xref=Rhea:RHEA:29263, ChEBI:CHEBI:29101, ChEBI:CHEBI:57427; CC Evidence={ECO:0000256|ARBA:ARBA00034222}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out); CC Xref=Rhea:RHEA:68240, ChEBI:CHEBI:29101, ChEBI:CHEBI:57844; CC Evidence={ECO:0000256|ARBA:ARBA00034276}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-phenylalanine(in) + Na(+)(in) = L-phenylalanine(out) + CC Na(+)(out); Xref=Rhea:RHEA:68244, ChEBI:CHEBI:29101, CC ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00034253}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-pipecolate(in) + Na(+)(in) = L-pipecolate(out) + Na(+)(out); CC Xref=Rhea:RHEA:71387, ChEBI:CHEBI:29101, ChEBI:CHEBI:61185; CC Evidence={ECO:0000256|ARBA:ARBA00034235}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out); CC Xref=Rhea:RHEA:28967, ChEBI:CHEBI:29101, ChEBI:CHEBI:60039; CC Evidence={ECO:0000256|ARBA:ARBA00033708}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out); CC Xref=Rhea:RHEA:29575, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384; CC Evidence={ECO:0000256|ARBA:ARBA00034261}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out); CC Xref=Rhea:RHEA:69999, ChEBI:CHEBI:29101, ChEBI:CHEBI:57926; CC Evidence={ECO:0000256|ARBA:ARBA00034271}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-valine(in) + Na(+)(in) = L-valine(out) + Na(+)(out); CC Xref=Rhea:RHEA:29267, ChEBI:CHEBI:29101, ChEBI:CHEBI:57762; CC Evidence={ECO:0000256|ARBA:ARBA00034282}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC CC 2.A.22) family. SLC6A15 subfamily. {ECO:0000256|ARBA:ARBA00006563}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NWX12987.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VZRW01001657; NWX12987.1; -; Genomic_DNA. DR AlphaFoldDB; A0A7K6TQZ0; -. DR Proteomes; UP000559068; Unassembled WGS sequence. DR GO; GO:0005886; C:plasma membrane; IEA:InterPro. DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW. DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW. DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. DR CDD; cd11522; SLC6sbd_SBAT1; 1. DR InterPro; IPR042934; B(0)AT2. DR InterPro; IPR000175; Na/ntran_symport. DR InterPro; IPR002438; Neutral_aa_SLC6. DR InterPro; IPR037272; SNS_sf. DR NCBIfam; NF037979; Na_transp; 1. DR PANTHER; PTHR11616:SF101; SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT2; 1. DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1. DR Pfam; PF00209; SNF; 1. DR PRINTS; PR00176; NANEUSMPORT. DR PRINTS; PR01206; ORPHTRNSPORT. DR SUPFAM; SSF161070; SNF-like; 1. DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1. DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1. DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1. PE 3: Inferred from homology; KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Reference proteome {ECO:0000313|Proteomes:UP000559068}; KW Sodium {ECO:0000256|ARBA:ARBA00023201}; KW Sodium transport {ECO:0000256|ARBA:ARBA00023201}; KW Symport {ECO:0000256|RuleBase:RU003732}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003732}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}. FT TRANSMEM 70..88 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 100..121 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 142..169 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 226..247 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 259..282 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 302..323 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 335..356 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 458..484 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 496..515 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 527..549 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 570..594 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 614..639 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT REGION 23..56 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 680..706 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 23..43 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NWX12987.1" FT NON_TER 729 FT /evidence="ECO:0000313|EMBL:NWX12987.1" SQ SEQUENCE 729 AA; 81688 MW; 9FE697DC96E96E7A CRC64; MPKNSKVVKR ELDDEVIESV KDLLSNEDSS DDAFKKSELM VDDPEEKDVD VEEGSDIEDE RPAWNSKLQY ILAQVGFSVG LGNVWRFPYL CQKNGGGAYL VPYLILLLII GIPLFFLELA VGQRIRRGSI GVWNYISPKL GGIGFASCVV CFFVALYYNV IIGWSLFYFS QSFQHPLPWD QCPLVKNTSH TFVEPECEKS SATTYYWYRE ALNISSSLSE SGGLNWKMTI CLLAAWVMVC LAMIKGIQSS GKIMYFSSLF PYVVLLCFLI RGLLLNGSVD GIRHMFTPKL EIMLEPKVWR EAATQVFFAL GLGFGGVIAF SSYNKRDNNC HFDAVLVSFI NFFTSVLATL VVFAVLGFKA NIINEKCVIQ NSQKILKLLK IGNLSQDMIP HHINFSSITA EDYNLVYDII QKVKEEEFDS LGLKSCQIED ELNKAVQGTG LAFIAFTEAM THFPASPFWS VMFFLMLVNL GLGSMFGTIE GIITPIVDTF KVRKEILTVI CCLVAFFIGL IFVQHSGNYF VTMFDDYSAT LPLLIVVILE NIAVTRIYGI DKFVEDLKDM LGFSPSQYYY YMWKYVSPLV LLCLLVASIV QMGLSPPGYN AWIEDTATEE FHSYPTWGMI VCISLMVLAI LPVPIVFMVR RCNLIDDSSG SLASVSYKRG RIIKEPVNLE GDNTSLIHGK SPSEVPSPNF GKNIYRKQTG SPTLDTAPNG RYGIGYLMAD MPVMPESDL //