ID A0A7K6SRL7_CALNI Unreviewed; 979 AA. AC A0A7K6SRL7; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 29-MAY-2024, entry version 10. DE RecName: Full=Nuclear factor NF-kappa-B p105 subunit {ECO:0000256|ARBA:ARBA00020838}; DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 {ECO:0000256|ARBA:ARBA00032626}; DE Flags: Fragment; GN Name=Nfkb1 {ECO:0000313|EMBL:NWX00991.1}; GN ORFNames=CALNIC_R00754 {ECO:0000313|EMBL:NWX00991.1}; OS Caloenas nicobarica (Nicobar pigeon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Caloenas. OX NCBI_TaxID=187106 {ECO:0000313|EMBL:NWX00991.1, ECO:0000313|Proteomes:UP000546235}; RN [1] {ECO:0000313|EMBL:NWX00991.1, ECO:0000313|Proteomes:UP000546235} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=OUT-0007 {ECO:0000313|EMBL:NWX00991.1}; RC TISSUE=Blood {ECO:0000313|EMBL:NWX00991.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NWX00991.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VZSB01001145; NWX00991.1; -; Genomic_DNA. DR AlphaFoldDB; A0A7K6SRL7; -. DR Proteomes; UP000546235; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR CDD; cd08797; Death_NFkB1_p105; 1. DR CDD; cd01177; IPT_NFkappaB; 1. DR CDD; cd07935; RHD-n_NFkB1; 1. DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1. DR Gene3D; 1.10.533.10; Death Domain, Fas; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR InterPro; IPR011029; DEATH-like_dom_sf. DR InterPro; IPR000488; Death_domain. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR014756; Ig_E-set. DR InterPro; IPR002909; IPT_dom. DR InterPro; IPR033926; IPT_NFkappaB. DR InterPro; IPR047096; NF-kB_p105_DD. DR InterPro; IPR030503; NF-kB_p105_RHD_N. DR InterPro; IPR000451; NFkB/Dor. DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf. DR InterPro; IPR030492; RHD_CS. DR InterPro; IPR032397; RHD_dimer. DR InterPro; IPR011539; RHD_DNA_bind_dom. DR InterPro; IPR037059; RHD_DNA_bind_dom_sf. DR PANTHER; PTHR24169:SF9; NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT; 1. DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1. DR Pfam; PF12796; Ank_2; 2. DR Pfam; PF00531; Death; 1. DR Pfam; PF16179; RHD_dimer; 1. DR Pfam; PF00554; RHD_DNA_bind; 1. DR PRINTS; PR00057; NFKBTNSCPFCT. DR SMART; SM00248; ANK; 7. DR SMART; SM00005; DEATH; 1. DR SMART; SM00429; IPT; 1. DR SUPFAM; SSF48403; Ankyrin repeat; 1. DR SUPFAM; SSF47986; DEATH domain; 1. DR SUPFAM; SSF81296; E set domains; 1. DR SUPFAM; SSF49417; p53-like transcription factors; 1. DR PROSITE; PS50297; ANK_REP_REGION; 6. DR PROSITE; PS50088; ANK_REPEAT; 6. DR PROSITE; PS01204; REL_1; 1. DR PROSITE; PS50254; REL_2; 1. PE 4: Predicted; KW Activator {ECO:0000256|ARBA:ARBA00023159}; KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE- KW ProRule:PRU00023}; DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Reference proteome {ECO:0000313|Proteomes:UP000546235}; KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}. FT DOMAIN 42..249 FT /note="RHD" FT /evidence="ECO:0000259|PROSITE:PS50254" FT REPEAT 537..569 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 576..608 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 609..641 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 645..677 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 679..712 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 713..745 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REGION 423..481 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 888..917 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 425..439 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 440..481 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NWX00991.1" FT NON_TER 979 FT /evidence="ECO:0000313|EMBL:NWX00991.1" SQ SEQUENCE 979 AA; 107775 MW; CE29EB851D2FADBC CRC64; MAGEDSYIMS DPQMFTMDQF MGMNALFNNT NYITSDLPLR TADGPYLQII EQPKQRGFRF RYVCEGPSHG GLPGASSEKN KKSYPQVKIC NYVGPAKVIV QLVTNGKYVH LHAHSLVGKF CEDGVCTVNA GPKDMVVGFA NLGILHVTKK KVFETLEARM IDACKKGYNP ELLVHPELGY LQADACGDRQ LTEREREIIR QAAVQQTKEM DLSVVRLMFT AFLPDSNGSF TRKLDPVISD AIYDSKAPNA SNLKIVRMDR TAGCVTGGEE IYLLCDKVQK DDIQIRFYEE DENGGMWEGF GDFSPTDVHR QFAIVFKTPK YRDVNITKPA SVFVQLRRKS DLETSEPKPF LYYPEIKDKE EVQRKRQKLM PNFSDGYGGG SGGGGGGMYG GGGGGAGSGF SYPSYGYSTF AGMHFHPGIT KSNAGMKHEL SNSTADQDGK NSDKQSDKWD TKHEMKMETM EKNECRTSDE NEKEDAASSC KTEVNEADCR WQDGLFLEKA MQLAKRHCNA LFDYAVTGDV KMLLAVQRHL TVVQDDNGDN VLHLAIIHLH AELVKNLLEV MRDLNSNDII NMRNDLYQTP LHLAVITKQA EVVEDLLRAG ADVSLLDRHG NSILHLAAAE GDDKILSVLL KYKKILSMVN LSNGEGLSAI HMVVMANSMS CLKQLIAAGV NVNAQEQKSG RTALHLAVEH ENIPLAGCLL LEGDADVDST TYDGTTPLHI AAGRGSTKLA AVLKAAGADP HIENFEPLFD LDDVKADEDD DEGIVPGTTP LDMAANCEVY DILNGKPYEA AVVSEDLLPQ GHLRELNESC RMQLYKLLEA PDPRKNWSTL AQKLGLGILN NAFRLSPSPS KTLLDNYEVS GGTVQELIAA LKQMDHTEAV EMIQKALSIS RSPSQQQDNT AKALPLSSPP TSANRETGEL YNSKFQDTES TCDSGVETSF RRLSFTYLDS LNSKSSVTLS KMTLGYSQES SAQSNYIAN //