ID A0A7K6F307_9CORV Unreviewed; 708 AA. AC A0A7K6F307; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 03-MAY-2023, entry version 8. DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365}; DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728}; DE Flags: Fragment; GN Name=Mpeg1 {ECO:0000313|EMBL:NWV44938.1}; GN ORFNames=DAPCHR_R00969 {ECO:0000313|EMBL:NWV44938.1}; OS Daphoenositta chrysoptera (varied sittella). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Pachycephalidae; OC Daphoenositta. OX NCBI_TaxID=254528 {ECO:0000313|EMBL:NWV44938.1, ECO:0000313|Proteomes:UP000557315}; RN [1] {ECO:0000313|EMBL:NWV44938.1, ECO:0000313|Proteomes:UP000557315} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B10K-DU-029-47 {ECO:0000313|EMBL:NWV44938.1}; RC TISSUE=Heart {ECO:0000313|EMBL:NWV44938.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane CC {ECO:0000256|ARBA:ARBA00004358}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004358}. Membrane CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the MPEG1 family. CC {ECO:0000256|ARBA:ARBA00007256}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NWV44938.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VZRO01000206; NWV44938.1; -; Genomic_DNA. DR AlphaFoldDB; A0A7K6F307; -. DR Proteomes; UP000557315; Unassembled WGS sequence. DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. DR CDD; cd22579; MPEG1_P2; 1. DR InterPro; IPR020864; MACPF. DR InterPro; IPR039707; MPEG1. DR PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1. DR PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1. DR Pfam; PF01823; MACPF; 1. DR SMART; SM00457; MACPF; 1. DR PROSITE; PS51412; MACPF_2; 1. PE 3: Inferred from homology; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000557315}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}. FT SIGNAL 1..17 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 18..708 FT /note="Macrophage-expressed gene 1 protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5029458919" FT TRANSMEM 646..667 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 25..340 FT /note="MACPF" FT /evidence="ECO:0000259|PROSITE:PS51412" FT REGION 681..708 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NWV44938.1" FT NON_TER 708 FT /evidence="ECO:0000313|EMBL:NWV44938.1" SQ SEQUENCE 708 AA; 76532 MW; 9B04C5245468D393 CRC64; VLLTWALLAW VTGAGQPQEL SSSSGFGVCG RTSKLSRLGV LPGGGWDNLR NLDMGRVINL GYSQCKTTED GSYVIPDEIF TIPRKQSNLD INSEIIESWK DYQSITSASI NLELSLFSSI NGKFSNDFHR TKTHHVRDQA VTTRVQVRNL VYTAKIDPEA ALDKAFKKQL LTIASHLENN QTQMADFLAE VLVLNYGTHA ITSVDAGATL VQEDQIKATF LKDSWATRSA VTASAGVAFH SIVSVGTKES LDVSSGFTKH YLENRTNSRV ESIGGTPFYP GITLKTWQER IQNQLVALDR SGLPLYYFIK PSTVPELPAP TVRRVARRVE LAVRRYYTFN TAPGCTDASS PNFNFHANTD DGSCEGTMAN FTFGGVFQEC VGLAGPDTGV LCRALEQRNP LTGTFSCPAT YTPVLLGMQE REEGHSHLEC HKKCTLGIFC HHKCQDVFWL SRVQFSAYWC ATSGPVAPNS GYLFGGLFST HGANPITGAQ SCPSGYFPLK LFGELRVCVS QDYEGGAEYA VPFGGFFSCQ AGNPLAGQHQ GTAEDPHAKG CPPGFSQHLA LISDSCQVQF CVQAGLLTGG SLPPARLPPF TQPPSNLPAV DTLMVRDGDS TWVRDGQSHA WRLAQPEEVQ HVAEMVRGRG LSGGEVAGVT AAVLAGLATV LGIAWYGRQR YRARGYRALG TGDSPAPASP EHSTVLSVGE GYQQGPRG //