ID A0A7K5KF47_9TYRA Unreviewed; 464 AA. AC A0A7K5KF47; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 24-JAN-2024, entry version 9. DE RecName: Full=Keratin, type I cytoskeletal 14 {ECO:0000256|ARBA:ARBA00040326}; DE AltName: Full=Cytokeratin-14 {ECO:0000256|ARBA:ARBA00041705}; DE AltName: Full=Keratin-14 {ECO:0000256|ARBA:ARBA00042490}; DE Flags: Fragment; GN Name=Krt14_0 {ECO:0000313|EMBL:NWT04880.1}; GN ORFNames=MIOMAC_R13390 {ECO:0000313|EMBL:NWT04880.1}; OS Mionectes macconnelli (McConnell's flycatcher). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Tyrannidae; Mionectes. OX NCBI_TaxID=254557 {ECO:0000313|EMBL:NWT04880.1, ECO:0000313|Proteomes:UP000525714}; RN [1] {ECO:0000313|EMBL:NWT04880.1, ECO:0000313|Proteomes:UP000525714} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B10K-DU-003-16 {ECO:0000313|EMBL:NWT04880.1}; RC TISSUE=Mixed tissue sample {ECO:0000313|EMBL:NWT04880.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The nonhelical tail domain is involved in promoting KRT5- CC KRT14 filaments to self-organize into large bundles and enhances the CC mechanical properties involved in resilience of keratin intermediate CC filaments in vitro. {ECO:0000256|ARBA:ARBA00037229}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the intermediate filament family. CC {ECO:0000256|RuleBase:RU000685}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NWT04880.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VYZC01000739; NWT04880.1; -; Genomic_DNA. DR AlphaFoldDB; A0A7K5KF47; -. DR Proteomes; UP000525714; Unassembled WGS sequence. DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR Gene3D; 1.20.5.170; -; 1. DR Gene3D; 1.20.5.500; Single helix bin; 1. DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1. DR InterPro; IPR018039; IF_conserved. DR InterPro; IPR039008; IF_rod_dom. DR InterPro; IPR002957; Keratin_I. DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1. DR PANTHER; PTHR23239:SF368; KERATIN, TYPE I CYTOSKELETAL 14; 1. DR Pfam; PF00038; Filament; 1. DR PRINTS; PR01248; TYPE1KERATIN. DR SMART; SM01391; Filament; 1. DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2. DR PROSITE; PS00226; IF_ROD_1; 1. DR PROSITE; PS51842; IF_ROD_2; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754, KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744}; KW Reference proteome {ECO:0000313|Proteomes:UP000525714}. FT DOMAIN 106..417 FT /note="IF rod" FT /evidence="ECO:0000259|PROSITE:PS51842" FT REGION 1..22 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 110..144 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 209..395 FT /evidence="ECO:0000256|SAM:Coils" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NWT04880.1" FT NON_TER 464 FT /evidence="ECO:0000313|EMBL:NWT04880.1" SQ SEQUENCE 464 AA; 50824 MW; CD09DB5444EB70A6 CRC64; MSTTVRQYSS STSLKGFGSL GGGSSRLSSV RVGGGGYRAP SVHGGSGSYS VSSRVVSGLG SGFGGSYCSS IGGALGGGFG GSYGAGFGTG FGGGFGGGDG ILPAGEKETM QNLNDRLAAY LDKVRALEEA NTDLEVKIRE WYKKQGPGPD RDYSPYYRTI EELRNKILSA TVENANIVLQ IDNARLAADD FRTKFESEQA LRLSVEADIN GLRRVLDELT LSRADLEMQI ENLKEELAYL KKNHEEEMTA LRGQVGGEIS VEMDAAPGID LTKILAEMRE QYESLAEKNR RDAEQWFFSK TEELNREVAI NTEQLQSGKT EITELRRTIQ SLEIDLQSQL STKAALEGTL ADTEARYGTQ LAQLQALITS VEEQLAELRC DMERQNQEYR VLLDVKCRLE QEIATYRRLL EGEDAHISSQ YSSAMSPHSG RDVVTSSRQV RTIVEEVQDG KVVSSREQVA LTTR //