ID A0A7K4MZL8_9ARCH Unreviewed; 188 AA. AC A0A7K4MZL8; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 02-JUN-2021, entry version 2. DE RecName: Full=GTP cyclohydrolase 1 {ECO:0000256|HAMAP-Rule:MF_00223}; DE EC=3.5.4.16 {ECO:0000256|HAMAP-Rule:MF_00223}; DE AltName: Full=GTP cyclohydrolase I {ECO:0000256|HAMAP-Rule:MF_00223}; DE Short=GTP-CH-I {ECO:0000256|HAMAP-Rule:MF_00223}; GN Name=folE {ECO:0000256|HAMAP-Rule:MF_00223, GN ECO:0000313|EMBL:NWJ67996.1}; GN ORFNames=HX834_01380 {ECO:0000313|EMBL:NWJ67996.1}; OS Marine Group I thaumarchaeote. OC Archaea; Thaumarchaeota; Thaumarchaeota incertae sedis; Marine Group I. OX NCBI_TaxID=2511932 {ECO:0000313|EMBL:NWJ67996.1, ECO:0000313|Proteomes:UP000554454}; RN [1] {ECO:0000313|EMBL:NWJ67996.1, ECO:0000313|Proteomes:UP000554454} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=D17 {ECO:0000313|EMBL:NWJ67996.1, RC ECO:0000313|Proteomes:UP000554454}; RX PubMed=30592124; RA Wang Y., Huang J.M., Cui G.J., Nunoura T., Takaki Y., Li W.L., Li J., RA Gao Z.M., Takai K., Zhang A.Q., Stepanauskas R.; RT "Genomics insights into ecotype formation of ammonia-oxidizing archaea in RT the deep ocean."; RL Environ. Microbiol. 21:716-729(2019). CC -!- CATALYTIC ACTIVITY: CC Reaction=GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + CC H(+); Xref=Rhea:RHEA:17473, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:15740, ChEBI:CHEBI:37565, ChEBI:CHEBI:58462; EC=3.5.4.16; CC Evidence={ECO:0000256|ARBA:ARBA00001052, ECO:0000256|HAMAP- CC Rule:MF_00223}; CC -!- PATHWAY: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate CC biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. CC {ECO:0000256|ARBA:ARBA00005080, ECO:0000256|HAMAP-Rule:MF_00223}. CC -!- SUBUNIT: Homopolymer. {ECO:0000256|HAMAP-Rule:MF_00223}. CC -!- SIMILARITY: Belongs to the GTP cyclohydrolase I family. CC {ECO:0000256|HAMAP-Rule:MF_00223}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NWJ67996.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JACATA010000003; NWJ67996.1; -; Genomic_DNA. DR UniPathway; UPA00848; UER00151. DR Proteomes; UP000554454; Unassembled WGS sequence. DR GO; GO:0003934; F:GTP cyclohydrolase I activity; IEA:UniProtKB-EC. DR Gene3D; 1.10.286.10; -; 1. DR Gene3D; 3.30.1130.10; -; 1. DR HAMAP; MF_00223; FolE; 1. DR InterPro; IPR043133; GTP-CH-I_C/QueF. DR InterPro; IPR043134; GTP-CH-I_N. DR InterPro; IPR001474; GTP_CycHdrlase_I. DR InterPro; IPR018234; GTP_CycHdrlase_I_CS. DR InterPro; IPR020602; GTP_CycHdrlase_I_dom. DR PANTHER; PTHR11109; PTHR11109; 1. DR Pfam; PF01227; GTP_cyclohydroI; 1. DR TIGRFAMs; TIGR00063; folE; 1. DR PROSITE; PS00859; GTP_CYCLOHYDROL_1_1; 1. DR PROSITE; PS00860; GTP_CYCLOHYDROL_1_2; 1. PE 3: Inferred from homology; KW GTP-binding {ECO:0000256|HAMAP-Rule:MF_00223}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00223}; KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_00223}; KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00223}; KW One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_00223}; KW Zinc {ECO:0000256|HAMAP-Rule:MF_00223}. FT DOMAIN 6..171 FT /note="GTP_cyclohydroI" FT /evidence="ECO:0000259|Pfam:PF01227" FT METAL 72 FT /note="Zinc" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00223" FT METAL 75 FT /note="Zinc" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00223" FT METAL 142 FT /note="Zinc" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00223" SQ SEQUENCE 188 AA; 21627 MW; 196CEDD14CD440F2 CRC64; MDEERIKKLV RELIIEIGED PTREGLIKTP ERIANAYKEI FGGYDSNSDL SVQFSEDSEV VVVRDIQFYS MCEHHMLPFF GKIQLAYSPN GRIFGISKLV RLVEKYSRRL QIQERMTKNI ADELYSHGVK GVAVITEAEH LCMKMRGVKN NASVSSAAFR GIYERKEEKE NIINIIKNPS KTFFTQNS //