ID A0A7J7FFG1_DICBM Unreviewed; 3760 AA. AC A0A7J7FFG1; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 27-NOV-2024, entry version 18. DE RecName: Full=Ryanodine receptor 1 {ECO:0000256|ARBA:ARBA00014291}; DE AltName: Full=Skeletal muscle calcium release channel {ECO:0000256|ARBA:ARBA00032969}; DE AltName: Full=Skeletal muscle ryanodine receptor {ECO:0000256|ARBA:ARBA00031197}; DE AltName: Full=Skeletal muscle-type ryanodine receptor {ECO:0000256|ARBA:ARBA00033030}; DE AltName: Full=Type 1 ryanodine receptor {ECO:0000256|ARBA:ARBA00032832}; GN ORFNames=HPG69_015594 {ECO:0000313|EMBL:KAF5926396.1}; OS Diceros bicornis minor (South-central black rhinoceros). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Perissodactyla; Rhinocerotidae; Diceros. OX NCBI_TaxID=77932 {ECO:0000313|EMBL:KAF5926396.1, ECO:0000313|Proteomes:UP000551758}; RN [1] {ECO:0000313|EMBL:KAF5926396.1, ECO:0000313|Proteomes:UP000551758} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SBR-YM {ECO:0000313|EMBL:KAF5926396.1}; RC TISSUE=Skin {ECO:0000313|EMBL:KAF5926396.1}; RX PubMed=32585004; RA Moodley Y., Westbury M.V., Russo I.M., Gopalakrishnan S., Rakotoarivelo A., RA Olsen R.A., Prost S., Tunstall T., Ryder O.A., Dalen L., Bruford M.W.; RT "Interspecific Gene Flow and the Evolution of Specialization in Black and RT White Rhinoceros."; RL Mol. Biol. Evol. 37:3105-3117(2020). CC -!- FUNCTION: Cytosolic calcium-activated calcium channel that mediates the CC release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and CC thereby plays a key role in triggering muscle contraction following CC depolarization of T-tubules. Repeated very high-level exercise CC increases the open probability of the channel and leads to Ca(2+) CC leaking into the cytoplasm. Can also mediate the release of Ca(2+) from CC intracellular stores in neurons, and may thereby promote prolonged CC Ca(2+) signaling in the brain. Required for normal embryonic CC development of muscle fibers and skeletal muscle. Required for normal CC heart morphogenesis, skin development and ossification during CC embryogenesis. {ECO:0000256|ARBA:ARBA00045680}. CC -!- SUBUNIT: Homotetramer. Can also form heterotetramers with RYR2. CC Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and CC protein phosphatase 1 (PP1). Repeated very high-level exercise CC decreases interaction with PDE4D and protein phosphatase 1 (PP1). CC Interacts with CALM; CALM with bound calcium inhibits the RYR1 channel CC activity. Interacts with S100A1. Interacts with FKBP1A; this stabilizes CC the closed conformation of the channel. Interacts with CACNA1S; CC interaction with CACNA1S is important for activation of the RYR1 CC channel. Interacts with CACNB1. Interacts with TRDN and ASPH; these CC interactions stimulate RYR1 channel activity. Interacts with SELENON. CC Interacts with scorpion calcins (AC P0DPT1; AC P0DM30; AC A0A1L4BJ42; CC AC P59868; AC P60254; AC B8QG00; AC L0GBR1; AC P60252; AC P60253). CC {ECO:0000256|ARBA:ARBA00046784}. CC -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004326}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KAF5926396.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JACDTQ010000768; KAF5926396.1; -; Genomic_DNA. DR Proteomes; UP000551758; Unassembled WGS sequence. DR GO; GO:0034704; C:calcium channel complex; IEA:TreeGrafter. DR GO; GO:0042383; C:sarcolemma; IEA:TreeGrafter. DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:TreeGrafter. DR GO; GO:0030018; C:Z disc; IEA:TreeGrafter. DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW. DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro. DR GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:TreeGrafter. DR GO; GO:0006941; P:striated muscle contraction; IEA:TreeGrafter. DR CDD; cd12877; SPRY1_RyR; 1. DR CDD; cd12878; SPRY2_RyR; 1. DR CDD; cd12879; SPRY3_RyR; 1. DR FunFam; 1.10.490.160:FF:000008; -; 1. DR FunFam; 2.60.120.920:FF:000019; Ryanodine receptor 1 (skeletal); 1. DR FunFam; 1.10.490.160:FF:000001; Ryanodine receptor 2 (Cardiac); 1. DR FunFam; 2.80.10.50:FF:000006; Ryanodine receptor 2 (Cardiac); 1. DR FunFam; 1.25.10.30:FF:000002; ryanodine receptor isoform X2; 1. DR FunFam; 2.60.120.920:FF:000002; ryanodine receptor isoform X2; 1. DR FunFam; 2.60.120.920:FF:000003; ryanodine receptor isoform X2; 1. DR Gene3D; 1.10.490.160; -; 2. DR Gene3D; 2.60.120.920; -; 3. DR Gene3D; 2.80.10.50; -; 2. DR Gene3D; 6.20.350.10; -; 1. DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1. DR InterPro; IPR001870; B30.2/SPRY. DR InterPro; IPR043136; B30.2/SPRY_sf. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR014821; Ins145_P3_rcpt. DR InterPro; IPR036300; MIR_dom_sf. DR InterPro; IPR016093; MIR_motif. DR InterPro; IPR000699; RIH_dom. DR InterPro; IPR013333; Ryan_recept. DR InterPro; IPR015925; Ryanodine_IP3_receptor. DR InterPro; IPR003032; Ryanodine_rcpt. DR InterPro; IPR048581; RYDR_Jsol. DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf. DR InterPro; IPR035761; SPRY1_RyR. DR InterPro; IPR035764; SPRY2_RyR. DR InterPro; IPR035762; SPRY3_RyR. DR InterPro; IPR003877; SPRY_dom. DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR46399:SF10; RYANODINE RECEPTOR 1; 1. DR Pfam; PF08709; Ins145_P3_rec; 1. DR Pfam; PF02815; MIR; 1. DR Pfam; PF01365; RYDR_ITPR; 2. DR Pfam; PF21119; RYDR_Jsol; 1. DR Pfam; PF02026; RyR; 4. DR Pfam; PF00622; SPRY; 3. DR PRINTS; PR00795; RYANODINER. DR SMART; SM00472; MIR; 3. DR SMART; SM00449; SPRY; 3. DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3. DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2. DR SUPFAM; SSF82109; MIR domain; 2. DR PROSITE; PS50188; B302_SPRY; 3. DR PROSITE; PS50919; MIR; 3. PE 4: Predicted; KW Calcium {ECO:0000256|ARBA:ARBA00022837}; KW Calcium channel {ECO:0000256|ARBA:ARBA00022673}; KW Calcium transport {ECO:0000256|ARBA:ARBA00022568}; KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860}; KW Developmental protein {ECO:0000256|ARBA:ARBA00022473}; KW Ion channel {ECO:0000256|ARBA:ARBA00022673}; KW Ion transport {ECO:0000256|ARBA:ARBA00022568}; KW Receptor {ECO:0000256|ARBA:ARBA00023170}; KW Reference proteome {ECO:0000313|Proteomes:UP000551758}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799}; KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}; KW Transport {ECO:0000256|ARBA:ARBA00022568}. FT DOMAIN 206..261 FT /note="MIR" FT /evidence="ECO:0000259|PROSITE:PS50919" FT DOMAIN 268..313 FT /note="MIR" FT /evidence="ECO:0000259|PROSITE:PS50919" FT DOMAIN 354..411 FT /note="MIR" FT /evidence="ECO:0000259|PROSITE:PS50919" FT DOMAIN 665..881 FT /note="B30.2/SPRY" FT /evidence="ECO:0000259|PROSITE:PS50188" FT DOMAIN 1097..1292 FT /note="B30.2/SPRY" FT /evidence="ECO:0000259|PROSITE:PS50188" FT DOMAIN 1440..1654 FT /note="B30.2/SPRY" FT /evidence="ECO:0000259|PROSITE:PS50188" FT REGION 1391..1467 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1480..1506 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1932..1982 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2449..2472 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2907..2937 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3552..3573 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1405..1434 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1933..1978 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2907..2922 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 3557..3573 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 3760 AA; 420452 MW; 3AC3E04FD8AEE88C CRC64; MGDGGEGEDE VQFLRTRELA ELGATDGEGA LRPPFILTLA ICPGEGGPLK EHPLPPPWTQ ALGEGLLRFA LPFQLRVSDP RLGGRDGNWN NRLRPRGLSR GEGRGAWPVV AAWVGCSDPP SRPQDDEVVL QCSATVLKEQ LKLCLAAEGF GNRLCFLEPT SNAQNVPPDL AICCFVLEQS LSVRALQEML ANTVEAGVES SQGGGHRTLL YGHAILLRHA HSGMYLSCLT TSRSMTDKLA FDVGLQEDAI GEACWWTTHP ASKQRSEGEK VRVGDDLILV SVSSERYLHL STASGELQVD ASFMQTLWNM NPICSGCEEG YVTGGHVLRL FHGHMDECLT ISPADSDDQR SWSGSHLRWG QPLRIRHVTT GRYLALTEDQ GLMVVDASKA HTKATSFCFR VSKEKLDMGP KRDVEGMGPP EIKYGESLCF VQHVASGLWL TYAAPDPKAL RLGVLKKKAI LHQEGHMDDA LSLTRCQHEE SQAARMIYST AGLYNQFIKG LDSFSGKPRG SGSPAGTALP IEGVILSLQD LIGYMEPPSE ELQHEEKQSK LRSLRNRQSL FQEEGMLSLV LNCIDRLNVY TTAAHFAEFA GEEAAESWKE IVNLLYELLA SLIRGNRTNC ALFSNNLDWL VSKLDRLEAS SGILEVLYCV LIESPEVLNI IQENHIKSII SLLDKHGRNH KVLDVLCSLC VCNGVAVRSN QDLITENLLP GRELLLQTNL INYVTSIRPN IFVGRAEGTT QYGKWYFEVM VDEVAPFLTA QATHLRVGWA LTEGYTPYPG GGEGWGGNGV GDDLYSYGFD GLHLWTGHVP RLVTSPGQHL LAPEDVVSCC LDLSVPSISF RINGCPVQGV FENFNLDGLF FPVVSFSAGI KVRFLLGGRH GEFKFLPPPG YAPCHEAVLP RERLHLEPIK EYRREGPRGP HLVGPSRCLS HTDFVPCPVD TVQIVLPPHL ERIREKLAEN IHELWALTRI EQGWTYGPVR DDNKRLHPCL VDFHSLPEPE RNYNLQMSGE TLKTLLALGC HVGMADEKAE DNLKKTKLPK TYMMSNGYKP APLDLSHVRL TPAQTTLVDR LAENGHNVWA RDRVAQGWSY SAVQDIPARR NPRLVPYRLL DEATKRSNRD SLCQAVRTLL GYGYNIEPPD QEPSLVESQS RWDRMRIFRA EKSYAVQSGR WYFEFEAVTT GEMRVGWARP ELRPDVELGA DELAYVFNGH RGQRWHLGSE LFGRPWQSGD VVGCMIDLTE NTIIFTLNGE ILMSDSGSET AFRDIEIGDG FLPVCSLGPG QVGHLNLGQD VSSLRFFAIC GLQEGFEPFA INMQRPVTTW FSKSLPQFEA VPLEHPHYEV ARVDGTVDTP PCLRLTHRTW GSQNSLVEML FLRLSLPVQF HQHFRCTAGA TPLAPPGLQP PAEDEARAAE PDPDYENLRR SAGRWGEAEG SKEGNAKEGA PGGTPQAGVE AQPARVENEK DATTEKNKKR GFLFKAKKAA MMTQPPATPT LPRLPHEVVP TNDRDDPEII LNTTTYYYSV RVFAGQEPSC VWVGWVTPDY HQHDMNFDLS KVRAVTVTMG DEQGNVHSSL KCSNCYMVWG GDFVSPGQQG RISHMDLVIG CLVDLATGLM TFTANGKESN TFFQVEPNTK LFPAVFVLPT HQNVIQFELG KQKNIMPLSA AMFLSERKNP APQCPPRLEV QMLMPVSWSR MPNHFLQVET RRAGERLGWA VQCREPLTMM ALHVPEENRC MDILELSERL DLQRFHSHTL RLYRAVCALG NNRVAHALCS HVDQAQLLHA LEDAHLPGPL RAGYYDLLIS IHLESACRSR RSMLSEYIVP LTPETRAITL FPPGRSAENG PRRYGLPGVG VTTSLRPPHH FSAPCFVAAL PAAGLAEAPA RLSPSIPLEA LRDKALRMLG EAVRDGGQHA RDPVGGSVEF QFVPVLKLVS TLLEEEEEEE EEEEEEDEEE KEEDEEEEAQ EKEDEEKEEE ELAEGEKEES LEEGLLQMKL PESVKLQMCH LLEYFCDQEL QHRVESLAAF AERYVDKLQA NQRDRYGLLM KAFTMSAAET ARRTREFRSP PQEQINMLLH FKDVEDEEDC LLPEEIRQDL LEFHQDLLAH CGIQLEGEEE EPEEEATLGS RLMSLLEKVR LVKKKKEKSE EEGPAEESKP QSLQELVSHT VVRWAQEDFV QSPELVRAMF SLLHRQYDGL GELLRALPRA YTISPSSMED TMSLLECLGQ IRSLLIVQMG PQEENLMIQS IGNIMNNKVF YQHPNLMRAL GMHETVMEVM VNVLGGGESK EIRFPKMVTS CCRFLCYFCR ISRQNQRSMF DHLSYLLENS GIGLGMQGST PLDVAAASVI DNNELALALQ EQDLEKVVSY LAGCGLQSCP MLLAKGYPDI GWNPCGGERY LDFLRFAVFV NGESVEENAN VVVRLLIRKP ECFGPALRGE GGSGLLATIE EAIRISEDPA RDGPGVRRDR RREHFGEEPP EENRVHLGHA IMSFYAALID LLGRCAPEMH LIQAGKGEAL RIRAILRSLV PLDDLVGIIS LPLQIPTLGK GAEDGAGLSK GVVPGRERMG LKGIPDPLAL LAHRWRSGAA QDVSILRAGP QGVHGALPGP RVRHREPGLL VARTGRGATF STTEMALALN RYLCLAVLPL ITKCAPLFAG TEHRAIMVDS MLHTVYRLSR GRSLTKAQRD VIEDCLMSLC RYIRPSMLQH LLRRLVFDVP ILNEFAKMPL KLLTNHYERC WKYYCLPTGW ANFGVTSEEE LHLTRKLFWG IFDSLAHKKY DQELYRMAMP CLCAIAGALP PDYVDASYSS KAEKKATVDA EGNFDPRPVE TLNVIIPEKL DSFINKFAEY THEKWAFDKI QNNWSYGENI DEELKTHPML RPYKTFSEKD KEIYRWPIKE SLKAMIAWEW TIEKAREGEE EKTEKKKTRK ISQSAQTYDP REGYNPQPPD LSGVTLSREL QAMAEQLAEN YHNTWGRKKK QELEAKGGGT HPLLVPYDTL TAKEKARDRE KAQELLKFLQ MNGYAVTRQD MELDTSSIEK RFAFGFLQQL LRWMDISQEF IAHLEAVVSS GRVEKSPHEQ EIKFFAKILL PLINQYFTNH CLYFLSTPAK VLGSGGHASN KEKEMITSLF CKLAALVRHR VSLFGTDAPA VVNCLHILAR SLDARTVMKS GPEIVKAGLR SFFESASEDI EKMVENLRLG KVSQARTQVK GVGQNLTYTT VALLPVLTTL FQHIAQHQFG DDVILDDVQV SCYRTLCSIY SLGTTRNPYV EKLRPALGEC LARLAAAMPV AFLEPQLNEY NACSVYTTKS PRERAILGLP NSVEEMCPDI PVLERLMADI GGLAESGARY TEMPHVIEIT LPMLCSYLPR WWERGPEAPP PALPAGAPPP CTAVTSDHLN SLLGNILRII VNNLGIDEAT WMKRLAVFAQ PIVSRARPEL LHSHFIPTIG RLRKRAGKVV AEEEQLRLEA KAEAQEGELL VRDEFSVLCR DLYALYPLLI RYVDNNRAHW LTEPNPSAEE LFRMVGEIFI YWSKSHNFKR EEQNFVVQNE INNMSFLTAD NKSKMAKSGG SDQERTKKKR RGDRYSVQTS LIVATLKKML PIGLNMCAPT DQDLIALAKT RYALALVLNL GPGGGARGQN FGSGSGAWGR RVTQWAGPWV GLGLERSLGS GPGSGAAPGL EAEPRSEPRL YRWSQGVPSA RESGLNLDLG TDGQLCLGRG RVWGHDRLSR PQIEHPYKSK KAVWHKLLSK QRRRAVVACF RMTPLYNLPT //