ID   A0A7J7FFG1_DICBM        Unreviewed;      3760 AA.
AC   A0A7J7FFG1;
DT   07-APR-2021, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 1.
DT   13-SEP-2023, entry version 12.
DE   RecName: Full=Skeletal muscle ryanodine receptor {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HPG69_015594 {ECO:0000313|EMBL:KAF5926396.1};
OS   Diceros bicornis minor (South-central black rhinoceros).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Rhinocerotidae; Diceros.
OX   NCBI_TaxID=77932 {ECO:0000313|EMBL:KAF5926396.1, ECO:0000313|Proteomes:UP000551758};
RN   [1] {ECO:0000313|EMBL:KAF5926396.1, ECO:0000313|Proteomes:UP000551758}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SBR-YM {ECO:0000313|EMBL:KAF5926396.1};
RC   TISSUE=Skin {ECO:0000313|EMBL:KAF5926396.1};
RX   PubMed=32585004;
RA   Moodley Y., Westbury M.V., Russo I.M., Gopalakrishnan S., Rakotoarivelo A.,
RA   Olsen R.A., Prost S., Tunstall T., Ryder O.A., Dalen L., Bruford M.W.;
RT   "Interspecific Gene Flow and the Evolution of Specialization in Black and
RT   White Rhinoceros.";
RL   Mol. Biol. Evol. 37:3105-3117(2020).
CC   -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004326}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAF5926396.1}.
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DR   EMBL; JACDTQ010000768; KAF5926396.1; -; Genomic_DNA.
DR   Proteomes; UP000551758; Unassembled WGS sequence.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.10.490.160; -; 2.
DR   Gene3D; 2.60.120.920; -; 3.
DR   Gene3D; 2.80.10.50; -; 2.
DR   Gene3D; 6.20.350.10; -; 1.
DR   Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR015925; Ryanodine_IP3_receptor.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46399:SF10; RYANODINE RECEPTOR 1; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 3.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR   SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR   SUPFAM; SSF82109; MIR domain; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 3.
PE   4: Predicted;
KW   Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW   Reference proteome {ECO:0000313|Proteomes:UP000551758};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT   DOMAIN          206..261
FT                   /note="MIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50919"
FT   DOMAIN          268..313
FT                   /note="MIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50919"
FT   DOMAIN          354..411
FT                   /note="MIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50919"
FT   DOMAIN          665..881
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   DOMAIN          1097..1292
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   DOMAIN          1440..1654
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   REGION          1391..1467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1480..1506
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1932..1982
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2449..2472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2907..2937
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3552..3573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1405..1434
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1933..1978
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2907..2922
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3557..3573
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3760 AA;  420452 MW;  3AC3E04FD8AEE88C CRC64;
     MGDGGEGEDE VQFLRTRELA ELGATDGEGA LRPPFILTLA ICPGEGGPLK EHPLPPPWTQ
     ALGEGLLRFA LPFQLRVSDP RLGGRDGNWN NRLRPRGLSR GEGRGAWPVV AAWVGCSDPP
     SRPQDDEVVL QCSATVLKEQ LKLCLAAEGF GNRLCFLEPT SNAQNVPPDL AICCFVLEQS
     LSVRALQEML ANTVEAGVES SQGGGHRTLL YGHAILLRHA HSGMYLSCLT TSRSMTDKLA
     FDVGLQEDAI GEACWWTTHP ASKQRSEGEK VRVGDDLILV SVSSERYLHL STASGELQVD
     ASFMQTLWNM NPICSGCEEG YVTGGHVLRL FHGHMDECLT ISPADSDDQR SWSGSHLRWG
     QPLRIRHVTT GRYLALTEDQ GLMVVDASKA HTKATSFCFR VSKEKLDMGP KRDVEGMGPP
     EIKYGESLCF VQHVASGLWL TYAAPDPKAL RLGVLKKKAI LHQEGHMDDA LSLTRCQHEE
     SQAARMIYST AGLYNQFIKG LDSFSGKPRG SGSPAGTALP IEGVILSLQD LIGYMEPPSE
     ELQHEEKQSK LRSLRNRQSL FQEEGMLSLV LNCIDRLNVY TTAAHFAEFA GEEAAESWKE
     IVNLLYELLA SLIRGNRTNC ALFSNNLDWL VSKLDRLEAS SGILEVLYCV LIESPEVLNI
     IQENHIKSII SLLDKHGRNH KVLDVLCSLC VCNGVAVRSN QDLITENLLP GRELLLQTNL
     INYVTSIRPN IFVGRAEGTT QYGKWYFEVM VDEVAPFLTA QATHLRVGWA LTEGYTPYPG
     GGEGWGGNGV GDDLYSYGFD GLHLWTGHVP RLVTSPGQHL LAPEDVVSCC LDLSVPSISF
     RINGCPVQGV FENFNLDGLF FPVVSFSAGI KVRFLLGGRH GEFKFLPPPG YAPCHEAVLP
     RERLHLEPIK EYRREGPRGP HLVGPSRCLS HTDFVPCPVD TVQIVLPPHL ERIREKLAEN
     IHELWALTRI EQGWTYGPVR DDNKRLHPCL VDFHSLPEPE RNYNLQMSGE TLKTLLALGC
     HVGMADEKAE DNLKKTKLPK TYMMSNGYKP APLDLSHVRL TPAQTTLVDR LAENGHNVWA
     RDRVAQGWSY SAVQDIPARR NPRLVPYRLL DEATKRSNRD SLCQAVRTLL GYGYNIEPPD
     QEPSLVESQS RWDRMRIFRA EKSYAVQSGR WYFEFEAVTT GEMRVGWARP ELRPDVELGA
     DELAYVFNGH RGQRWHLGSE LFGRPWQSGD VVGCMIDLTE NTIIFTLNGE ILMSDSGSET
     AFRDIEIGDG FLPVCSLGPG QVGHLNLGQD VSSLRFFAIC GLQEGFEPFA INMQRPVTTW
     FSKSLPQFEA VPLEHPHYEV ARVDGTVDTP PCLRLTHRTW GSQNSLVEML FLRLSLPVQF
     HQHFRCTAGA TPLAPPGLQP PAEDEARAAE PDPDYENLRR SAGRWGEAEG SKEGNAKEGA
     PGGTPQAGVE AQPARVENEK DATTEKNKKR GFLFKAKKAA MMTQPPATPT LPRLPHEVVP
     TNDRDDPEII LNTTTYYYSV RVFAGQEPSC VWVGWVTPDY HQHDMNFDLS KVRAVTVTMG
     DEQGNVHSSL KCSNCYMVWG GDFVSPGQQG RISHMDLVIG CLVDLATGLM TFTANGKESN
     TFFQVEPNTK LFPAVFVLPT HQNVIQFELG KQKNIMPLSA AMFLSERKNP APQCPPRLEV
     QMLMPVSWSR MPNHFLQVET RRAGERLGWA VQCREPLTMM ALHVPEENRC MDILELSERL
     DLQRFHSHTL RLYRAVCALG NNRVAHALCS HVDQAQLLHA LEDAHLPGPL RAGYYDLLIS
     IHLESACRSR RSMLSEYIVP LTPETRAITL FPPGRSAENG PRRYGLPGVG VTTSLRPPHH
     FSAPCFVAAL PAAGLAEAPA RLSPSIPLEA LRDKALRMLG EAVRDGGQHA RDPVGGSVEF
     QFVPVLKLVS TLLEEEEEEE EEEEEEDEEE KEEDEEEEAQ EKEDEEKEEE ELAEGEKEES
     LEEGLLQMKL PESVKLQMCH LLEYFCDQEL QHRVESLAAF AERYVDKLQA NQRDRYGLLM
     KAFTMSAAET ARRTREFRSP PQEQINMLLH FKDVEDEEDC LLPEEIRQDL LEFHQDLLAH
     CGIQLEGEEE EPEEEATLGS RLMSLLEKVR LVKKKKEKSE EEGPAEESKP QSLQELVSHT
     VVRWAQEDFV QSPELVRAMF SLLHRQYDGL GELLRALPRA YTISPSSMED TMSLLECLGQ
     IRSLLIVQMG PQEENLMIQS IGNIMNNKVF YQHPNLMRAL GMHETVMEVM VNVLGGGESK
     EIRFPKMVTS CCRFLCYFCR ISRQNQRSMF DHLSYLLENS GIGLGMQGST PLDVAAASVI
     DNNELALALQ EQDLEKVVSY LAGCGLQSCP MLLAKGYPDI GWNPCGGERY LDFLRFAVFV
     NGESVEENAN VVVRLLIRKP ECFGPALRGE GGSGLLATIE EAIRISEDPA RDGPGVRRDR
     RREHFGEEPP EENRVHLGHA IMSFYAALID LLGRCAPEMH LIQAGKGEAL RIRAILRSLV
     PLDDLVGIIS LPLQIPTLGK GAEDGAGLSK GVVPGRERMG LKGIPDPLAL LAHRWRSGAA
     QDVSILRAGP QGVHGALPGP RVRHREPGLL VARTGRGATF STTEMALALN RYLCLAVLPL
     ITKCAPLFAG TEHRAIMVDS MLHTVYRLSR GRSLTKAQRD VIEDCLMSLC RYIRPSMLQH
     LLRRLVFDVP ILNEFAKMPL KLLTNHYERC WKYYCLPTGW ANFGVTSEEE LHLTRKLFWG
     IFDSLAHKKY DQELYRMAMP CLCAIAGALP PDYVDASYSS KAEKKATVDA EGNFDPRPVE
     TLNVIIPEKL DSFINKFAEY THEKWAFDKI QNNWSYGENI DEELKTHPML RPYKTFSEKD
     KEIYRWPIKE SLKAMIAWEW TIEKAREGEE EKTEKKKTRK ISQSAQTYDP REGYNPQPPD
     LSGVTLSREL QAMAEQLAEN YHNTWGRKKK QELEAKGGGT HPLLVPYDTL TAKEKARDRE
     KAQELLKFLQ MNGYAVTRQD MELDTSSIEK RFAFGFLQQL LRWMDISQEF IAHLEAVVSS
     GRVEKSPHEQ EIKFFAKILL PLINQYFTNH CLYFLSTPAK VLGSGGHASN KEKEMITSLF
     CKLAALVRHR VSLFGTDAPA VVNCLHILAR SLDARTVMKS GPEIVKAGLR SFFESASEDI
     EKMVENLRLG KVSQARTQVK GVGQNLTYTT VALLPVLTTL FQHIAQHQFG DDVILDDVQV
     SCYRTLCSIY SLGTTRNPYV EKLRPALGEC LARLAAAMPV AFLEPQLNEY NACSVYTTKS
     PRERAILGLP NSVEEMCPDI PVLERLMADI GGLAESGARY TEMPHVIEIT LPMLCSYLPR
     WWERGPEAPP PALPAGAPPP CTAVTSDHLN SLLGNILRII VNNLGIDEAT WMKRLAVFAQ
     PIVSRARPEL LHSHFIPTIG RLRKRAGKVV AEEEQLRLEA KAEAQEGELL VRDEFSVLCR
     DLYALYPLLI RYVDNNRAHW LTEPNPSAEE LFRMVGEIFI YWSKSHNFKR EEQNFVVQNE
     INNMSFLTAD NKSKMAKSGG SDQERTKKKR RGDRYSVQTS LIVATLKKML PIGLNMCAPT
     DQDLIALAKT RYALALVLNL GPGGGARGQN FGSGSGAWGR RVTQWAGPWV GLGLERSLGS
     GPGSGAAPGL EAEPRSEPRL YRWSQGVPSA RESGLNLDLG TDGQLCLGRG RVWGHDRLSR
     PQIEHPYKSK KAVWHKLLSK QRRRAVVACF RMTPLYNLPT
//