ID A0A7J7F7X3_DICBM Unreviewed; 463 AA. AC A0A7J7F7X3; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 03-MAY-2023, entry version 9. DE RecName: Full=Lipase domain-containing protein {ECO:0000259|Pfam:PF00151}; GN ORFNames=HPG69_010420 {ECO:0000313|EMBL:KAF5923988.1}; OS Diceros bicornis minor (South-central black rhinoceros). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Perissodactyla; Rhinocerotidae; Diceros. OX NCBI_TaxID=77932 {ECO:0000313|EMBL:KAF5923988.1, ECO:0000313|Proteomes:UP000551758}; RN [1] {ECO:0000313|EMBL:KAF5923988.1, ECO:0000313|Proteomes:UP000551758} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SBR-YM {ECO:0000313|EMBL:KAF5923988.1}; RC TISSUE=Skin {ECO:0000313|EMBL:KAF5923988.1}; RX PubMed=32585004; RA Moodley Y., Westbury M.V., Russo I.M., Gopalakrishnan S., Rakotoarivelo A., RA Olsen R.A., Prost S., Tunstall T., Ryder O.A., Dalen L., Bruford M.W.; RT "Interspecific Gene Flow and the Evolution of Specialization in Black and RT White Rhinoceros."; RL Mol. Biol. Evol. 37:3105-3117(2020). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family. CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KAF5923988.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JACDTQ010001070; KAF5923988.1; -; Genomic_DNA. DR AlphaFoldDB; A0A7J7F7X3; -. DR Proteomes; UP000551758; Unassembled WGS sequence. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro. DR GO; GO:0016298; F:lipase activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. DR CDD; cd00707; Pancreat_lipase_like; 1. DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1. DR InterPro; IPR029058; AB_hydrolase. DR InterPro; IPR013818; Lipase. DR InterPro; IPR016272; Lipase_LIPH. DR InterPro; IPR033906; Lipase_N. DR InterPro; IPR000734; TAG_lipase. DR PANTHER; PTHR11610; LIPASE; 1. DR PANTHER; PTHR11610:SF111; PHOSPHOLIPASE A1 MEMBER A; 1. DR Pfam; PF00151; Lipase; 1. DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1. DR PRINTS; PR00821; TAGLIPASE. DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1. PE 3: Inferred from homology; KW Calcium {ECO:0000256|PIRSR:PIRSR000865-2}; KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2}; KW Reference proteome {ECO:0000313|Proteomes:UP000551758}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..463 FT /note="Lipase domain-containing protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5029905585" FT DOMAIN 17..343 FT /note="Lipase" FT /evidence="ECO:0000259|Pfam:PF00151" FT ACT_SITE 173 FT /note="Nucleophile" FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1" FT ACT_SITE 197 FT /note="Charge relay system" FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1" FT ACT_SITE 267 FT /note="Charge relay system" FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1" FT BINDING 211 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2" FT BINDING 213 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2" FT BINDING 216 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2" SQ SEQUENCE 463 AA; 50664 MW; C0903F1F41450234 CRC64; MPPGLWERRC WVWGLLLWLS VGNAGDAPPT QQPKCTDFQN ANLLRGTNLK VQFLLFTPSD PSCGQLVEES SDIQNSGFNV TLGTKLIIHG FRALGTKPSW IGKFIGALLR AVDANVIAVD WVYGSSGAYF SAVENVVKLG LEISRFLRKL LVGAEELRVL GVSESSIHIL GVSLGAHVGG MVGHFYKGQL GRITGLDPAG PEYTRASLEE RLDAGDALFV EAIHTDTDNL GIRIPVGHVD YFVNGGQDQP GCPSFIHAGY SYLICDHMRA VHLYISALEN SCPLMAFPCA SYKAFLAGHC LDCFNPFLLS CPRIGLVEQD GVKIEPLPKE VRVYLLTSSK APYCVHHSFV EFYLQEPRKK DTSIAVTFLS GNVTSSVKIT IPRQQLQGKG VIAHPNPQCQ INQVKLKLQA SNRVWKKDRT TIVGTFCTAP LPVHDNKKMV CLPEPVNLQA SVTVSHDLKI TCV //