ID A0A7J2IDN7_9ARCH Unreviewed; 308 AA. AC A0A7J2IDN7; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 22-FEB-2023, entry version 6. DE RecName: Full=Aspartate carbamoyltransferase {ECO:0000256|HAMAP-Rule:MF_00001}; DE EC=2.1.3.2 {ECO:0000256|HAMAP-Rule:MF_00001}; DE AltName: Full=Aspartate transcarbamylase {ECO:0000256|HAMAP-Rule:MF_00001}; DE Short=ATCase {ECO:0000256|HAMAP-Rule:MF_00001}; GN Name=pyrB {ECO:0000256|HAMAP-Rule:MF_00001, GN ECO:0000313|EMBL:HDH41316.1}; GN ORFNames=ENG12_02780 {ECO:0000313|EMBL:HDH41316.1}; OS Candidatus Altiarchaeales archaeon. OC Archaea; Candidatus Altiarchaeota; Candidatus Altiarchaeales. OX NCBI_TaxID=2250256 {ECO:0000313|EMBL:HDH41316.1}; RN [1] {ECO:0000313|EMBL:HDH41316.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HyVt-188 {ECO:0000313|EMBL:HDH41316.1}; RX PubMed=31911466; RA Zhou Z., Liu Y., Xu W., Pan J., Luo Z.H., Li M.; RT "Genome- and Community-Level Interaction Insights into Carbon Utilization RT and Element Cycling Functions of Hydrothermarchaeota in Hydrothermal RT Sediment."; RL mSystems 5:e00795-e00719(2020). CC -!- CATALYTIC ACTIVITY: CC Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L- CC aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:58228; EC=2.1.3.2; CC Evidence={ECO:0000256|ARBA:ARBA00001363, ECO:0000256|HAMAP- CC Rule:MF_00001}; CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; CC (S)-dihydroorotate from bicarbonate: step 2/3. CC {ECO:0000256|ARBA:ARBA00004852, ECO:0000256|HAMAP-Rule:MF_00001}. CC -!- SUBUNIT: Heterooligomer of catalytic and regulatory chains. CC {ECO:0000256|HAMAP-Rule:MF_00001}. CC -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase CC superfamily. ATCase family. {ECO:0000256|HAMAP-Rule:MF_00001}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:HDH41316.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQZU01000100; HDH41316.1; -; Genomic_DNA. DR AlphaFoldDB; A0A7J2IDN7; -. DR UniPathway; UPA00070; UER00116. DR Proteomes; UP000886325; Unassembled WGS sequence. DR GO; GO:0016597; F:amino acid binding; IEA:InterPro. DR GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro. DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro. DR Gene3D; 3.40.50.1370; Aspartate/ornithine carbamoyltransferase; 2. DR HAMAP; MF_00001; Asp_carb_tr; 1. DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd. DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase. DR InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf. DR InterPro; IPR002082; Asp_carbamoyltransf. DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd. DR PANTHER; PTHR45753:SF6; ASPARTATE CARBAMOYLTRANSFERASE; 1. DR PANTHER; PTHR45753; ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL; 1. DR Pfam; PF00185; OTCace; 1. DR Pfam; PF02729; OTCace_N; 1. DR PRINTS; PR00100; AOTCASE. DR PRINTS; PR00101; ATCASE. DR SUPFAM; SSF53671; Aspartate/ornithine carbamoyltransferase; 1. DR TIGRFAMs; TIGR00670; asp_carb_tr; 1. DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1. PE 3: Inferred from homology; KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975, ECO:0000256|HAMAP- KW Rule:MF_00001}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP- KW Rule:MF_00001}. FT DOMAIN 6..147 FT /note="Aspartate/ornithine carbamoyltransferase carbamoyl-P FT binding" FT /evidence="ECO:0000259|Pfam:PF02729" FT DOMAIN 154..301 FT /note="Aspartate/ornithine carbamoyltransferase Asp/Orn- FT binding" FT /evidence="ECO:0000259|Pfam:PF00185" SQ SEQUENCE 308 AA; 34465 MW; 65289EFA33ACD65A CRC64; MRWTKKHIIS INDFSRDEID FVLEKSGILE KKLGSSSTSS LMNGKILANL FFEPSTRTRM SFEAAMKRLG GITIGFDHPG ISSEVKGETI ADTVRIVSGY ADLIVIRHPI EGSARLASEY SDVPVINGGD GSNQHPTQTL LDLYTIKKEF KSIDGLDICI VGDLKYGRTV HSLASALGNY DVKIRFISPQ ELRAPRQIVK SLSDRGIEVK ETTKLNLKNS DVIYVTRIQK ERFPDPQEYE RVKGAFVLNL NSLEGIRENA IIMHPLPRVS EISPDIDATK HARYFEQAKN GIPVRMALLC LVCGIKFW //