ID A0A7I2YQ76_HUMAN Unreviewed; 77 AA. AC A0A7I2YQ76; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 29-MAY-2024, entry version 13. DE SubName: Full=Glycogen synthase kinase 3 alpha {ECO:0000313|Ensembl:ENSP00000502913.1}; DE Flags: Fragment; GN Name=GSK3A {ECO:0000313|Ensembl:ENSP00000502913.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000502913.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000502913.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000502913.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2024) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC006486; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877743; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456580; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; A0A7I2YQ76; -. DR SMR; A0A7I2YQ76; -. DR PeptideAtlas; A0A7I2YQ76; -. DR Ensembl; ENST00000676790.1; ENSP00000502913.1; ENSG00000105723.13. DR HGNC; HGNC:4616; GSK3A. DR GeneTree; ENSGT00520000055635; -. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000105723; Expressed in cortical plate and 213 other cell types or tissues. DR GO; GO:0030424; C:axon; IEA:TreeGrafter. DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter. DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:TreeGrafter. DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:TreeGrafter. DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:TreeGrafter. DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:TreeGrafter. DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:TreeGrafter. DR GO; GO:0010975; P:regulation of neuron projection development; IEA:TreeGrafter. DR PANTHER; PTHR24057; GLYCOGEN SYNTHASE KINASE-3 ALPHA; 1. DR PANTHER; PTHR24057:SF14; GLYCOGEN SYNTHASE KINASE-3 ALPHA; 1. PE 4: Predicted; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSP00000502913.1" SQ SEQUENCE 77 AA; 8508 MW; 8FCFA41994309324 CRC64; KDELYLNLVL EYVPETVYRV ARHFTKAKLT IPILYVKFCY PVPAAGVHVP ALPQLGLHPL PGRVSPRHQA PEPAGGP //