ID A0A7I2V480_HUMAN Unreviewed; 363 AA. AC A0A7I2V480; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 02-JUN-2021, entry version 2. DE RecName: Full=Cathepsin E {ECO:0000256|ARBA:ARBA00015580}; DE EC=3.4.23.34 {ECO:0000256|ARBA:ARBA00013240}; GN Name=CTSE {ECO:0000313|Ensembl:ENSP00000503796}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000503796, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000503796, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000503796} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2020) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=Similar to cathepsin D, but slightly broader specificity.; CC EC=3.4.23.34; Evidence={ECO:0000256|ARBA:ARBA00001898}; CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}. CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000256|ARBA:ARBA00004177}. CC -!- SIMILARITY: Belongs to the peptidase A1 family. CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX571818; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; FO535328; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000678712; ENSP00000503796; ENSG00000196188. DR HGNC; HGNC:2530; CTSE. DR OpenTargets; ENSG00000196188; -. DR GeneTree; ENSGT00940000161300; -. DR Proteomes; UP000005640; Chromosome 1. DR Gene3D; 2.40.70.10; -; 3. DR InterPro; IPR001461; Aspartic_peptidase_A1. DR InterPro; IPR001969; Aspartic_peptidase_AS. DR InterPro; IPR012848; Aspartic_peptidase_N. DR InterPro; IPR033145; Cathepsin_E. DR InterPro; IPR033121; PEPTIDASE_A1. DR InterPro; IPR021109; Peptidase_aspartic_dom_sf. DR PANTHER; PTHR47966; PTHR47966; 2. DR PANTHER; PTHR47966:SF26; PTHR47966:SF26; 2. DR Pfam; PF07966; A1_Propeptide; 1. DR Pfam; PF00026; Asp; 2. DR PRINTS; PR00792; PEPSIN. DR SUPFAM; SSF50630; SSF50630; 1. DR PROSITE; PS00141; ASP_PROTEASE; 2. DR PROSITE; PS51767; PEPTIDASE_A1; 1. PE 1: Evidence at protein level; KW Aspartyl protease {ECO:0000256|RuleBase:RU000454}; KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Endosome {ECO:0000256|ARBA:ARBA00022753}; KW Hydrolase {ECO:0000256|RuleBase:RU000454}; KW Protease {ECO:0000256|RuleBase:RU000454}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A7I2V480, KW ECO:0007829|ProteomicsDB:A0A7I2V480}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 20..363 FT /note="Cathepsin E" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5029632412" FT DOMAIN 78..363 FT /note="Peptidase A1" FT /evidence="ECO:0000259|PROSITE:PS51767" SQ SEQUENCE 363 AA; 39219 MW; CA3C91570A2B02D4 CRC64; MKTLLLLLLV LLELGEAQGS LHRVPLRRHP SLKKKLRARS QLSEFWKSHN LDMIQFTESC SMDQSAKEPL INYLDMEYFG TISIGSPPQN FTVIFDTGSS NLWVPSVYCT SPACKTHSRF QPSQSSTYSQ PGQSFSIQYG TGSLSGIIGA DQVSVEGLTV VGQQFGESVT EPGQTFVDAE FDGILGLGYP SLAVGGVTPV FDNMMAQNLV DLPMFSVYMS SNPEGGAGSE LIFGGYDHSH FSGSLNWVPV TKQAYWQIAL DNIQVGGTVM FCSEGCQAIV DTGTSLITGP SDKIKQLQNA IGAAPVDGED FVDGMQFCSS GFQGLDIHPP AGPLWILGDV FIRQFYSVFD RGNNRVGLAP AVP //