ID A0A7I0ZMY0_DANPL Unreviewed; 390 AA. AC A0A7I0ZMY0; DT 07-APR-2021, integrated into UniProtKB/TrEMBL. DT 07-APR-2021, sequence version 1. DT 29-SEP-2021, entry version 3. DE SubName: Full=insulin gene enhancer protein ISL-1 {ECO:0000313|RefSeq:XP_032521890.1}; GN Name=LOC116773525 {ECO:0000313|RefSeq:XP_032521890.1}; OS Danaus plexippus plexippus. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea; OC Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus. OX NCBI_TaxID=278856 {ECO:0000313|Proteomes:UP000596680, ECO:0000313|RefSeq:XP_032521890.1}; RN [1] {ECO:0000313|RefSeq:XP_032521890.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (FEB-2021) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, CC ECO:0000256|RuleBase:RU000682}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_032521890.1; XM_032665999.1. DR Proteomes; UP000596680; Genome assembly. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd00086; homeodomain; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR001781; Znf_LIM. DR Pfam; PF00046; Homeodomain; 1. DR Pfam; PF00412; LIM; 2. DR SMART; SM00389; HOX; 1. DR SMART; SM00132; LIM; 2. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS00478; LIM_DOMAIN_1; 2. DR PROSITE; PS50023; LIM_DOMAIN_2; 2. PE 4: Predicted; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE- KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE- KW ProRule:PRU00108}; Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}. FT DOMAIN 40..102 FT /note="LIM zinc-binding" FT /evidence="ECO:0000259|PROSITE:PS50023" FT DOMAIN 103..165 FT /note="LIM zinc-binding" FT /evidence="ECO:0000259|PROSITE:PS50023" FT DOMAIN 221..281 FT /note="Homeobox" FT /evidence="ECO:0000259|PROSITE:PS50071" FT DNA_BIND 223..282 FT /note="Homeobox" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108" FT REGION 166..227 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 166..208 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 390 AA; 43385 MW; 6FE9D577CD75D775 CRC64; MVMASGGGGL VQSPPDMLHH HNIMDTSSHV EMMPKKLRLS LCVGCGGQIH DQYILRVAPD LEWHAACLKC QECRQFLDES CTCFVRDGKT YCKRDYTRLF GTKCDKCGSS FSKNDFVMRA KTKIYHIDCF RCCACARQLI PGDEFALREG GALYCREDHD VLEKSANTSG SSAGNAESNN NTTLSNNNSH HPHELGSMSD SGSESGSHKS GRARAGAAAD GKPTRVRTVL NEKQLHTLRT CYAANPRPDA LMKEQLVEMT GLSPRVIRVW FQNKRCKDKK KTIQLKMQMQ QEKEGRRLGY MSMGVPLVAG SPVRHEAGSL ALEVTAYQPP WKALSDFALH ADLDRPQHSA AFQQLVNQMH GYDIPSLPPP RHEDNYVTYL ESDDSLPPSP //