ID A0A7G1JIJ1_STRPY Unreviewed; 398 AA. AC A0A7G1JIJ1; DT 02-JUN-2021, integrated into UniProtKB/TrEMBL. DT 02-JUN-2021, sequence version 1. DT 29-SEP-2021, entry version 2. DE RecName: Full=Exotoxin type B {ECO:0000256|ARBA:ARBA00014407}; DE EC=3.4.22.10 {ECO:0000256|ARBA:ARBA00012576}; DE AltName: Full=SPE B {ECO:0000256|ARBA:ARBA00015840}; DE AltName: Full=Streptococcal cysteine proteinase {ECO:0000256|ARBA:ARBA00018813}; DE AltName: Full=Streptococcus peptidase A {ECO:0000256|ARBA:ARBA00020388}; DE AltName: Full=Streptopain {ECO:0000256|ARBA:ARBA00019136}; GN Name=speB {ECO:0000313|EMBL:BCK42313.1}; GN ORFNames=KUN2590_16540 {ECO:0000313|EMBL:BCK40699.1}, KUN4944_14880 GN {ECO:0000313|EMBL:BCK42313.1}; OS Streptococcus pyogenes. OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=1314 {ECO:0000313|EMBL:BCK42313.1, ECO:0000313|Proteomes:UP000515381}; RN [1] {ECO:0000313|Proteomes:UP000515381, ECO:0000313|Proteomes:UP000515552} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KUN-0012590 {ECO:0000313|EMBL:BCK40699.1, RC ECO:0000313|Proteomes:UP000515552}, and KUN-0014944 RC {ECO:0000313|EMBL:BCK42313.1, ECO:0000313|Proteomes:UP000515381}; RA Murase K., Nozawa T., Nozawa A., Nakagawa I.; RT "Complete genome sequence of three Streptococcus species."; RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=Preferential cleavage with hydrophobic residues at P2, P1 and CC P1'.; EC=3.4.22.10; Evidence={ECO:0000256|ARBA:ARBA00001285}; CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the peptidase C10 family. CC {ECO:0000256|ARBA:ARBA00009693}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP023389; BCK40699.1; -; Genomic_DNA. DR EMBL; AP023390; BCK42313.1; -; Genomic_DNA. DR RefSeq; WP_031488619.1; NZ_WVFK01000003.1. DR Proteomes; UP000515381; Chromosome. DR Proteomes; UP000515552; Chromosome. DR InterPro; IPR038765; Papain-like_cys_pep_sf. DR InterPro; IPR000200; Peptidase_C10. DR InterPro; IPR025896; Spi_Prtas-inh. DR Pfam; PF13734; Inhibitor_I69; 1. DR Pfam; PF01640; Peptidase_C10; 1. DR PRINTS; PR00797; STREPTOPAIN. DR SUPFAM; SSF54001; SSF54001; 1. PE 3: Inferred from homology; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Protease {ECO:0000256|ARBA:ARBA00022670}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}; KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}. FT SIGNAL 1..27 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 28..398 FT /note="Exotoxin type B" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5030490656" FT DOMAIN 33..128 FT /note="Inhibitor_I69" FT /evidence="ECO:0000259|Pfam:PF13734" SQ SEQUENCE 398 AA; 43172 MW; CA67DF04252F911F CRC64; MNKKKLGIRL LSLLALGGFV LANPVFADQN FARNEKEAKD SAITFIQKSA AIKAGARSAE DIKLDKVNLG GELSGSNMYV YNISTGGFVI VSGDKRSPEI LGYSTSGSFD VNGKENIASF MESYVEQIKE NKKLDTTYAG TAEIKQPVVK SLLDSKGIHY NQGNPYNLLT PVIEKVKPGE QSFVGQHAAT GCVATATAQI MKYHNYPNKG LKDYTYTLSS NNPYFNHPKN LFAAISTRQY NWNNILPTYS GRESNVQKMA ISELMADVGI SVDMDYGPSS GSAGSSRVQR ALKENFGYNQ SVHQINRGDF SKQDWEAQID KELSQNQPVY YQGVGKVGGH AFVIDGADGR NFYHVNWGWG GVSDGFFRLD ALNPSALGTG GGAGGFNGYQ SAVVGIKP //