ID A0A7G1CVY5_CVHK1 Unreviewed; 928 AA. AC A0A7G1CVY5; DT 10-FEB-2021, integrated into UniProtKB/TrEMBL. DT 10-FEB-2021, sequence version 1. DT 28-JUN-2023, entry version 10. DE RecName: Full=ORF1ab polyprotein {ECO:0000256|PROSITE-ProRule:PRU01344}; DE Flags: Fragment; OS Human coronavirus HKU1 (HCoV-HKU1). OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; OC Betacoronavirus; Embecovirus. OX NCBI_TaxID=290028 {ECO:0000313|EMBL:AXT92508.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AXT92508.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PUMCH2410/2006 {ECO:0000313|EMBL:AXT92508.1}; RA Wang X., Ren L., Wang J.; RT "Molecular epidemiology of human coronavirus HKU1."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The replicase polyprotein of coronaviruses is a CC multifunctional protein: it contains the activities necessary for the CC transcription of negative stranded RNA, leader RNA, subgenomic mRNAs CC and progeny virion RNA as well as proteinases responsible for the CC cleavage of the polyprotein into functional products. CC {ECO:0000256|ARBA:ARBA00003368}. CC -!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family. CC {ECO:0000256|ARBA:ARBA00008087, ECO:0000256|PROSITE-ProRule:PRU01344}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MH556971; AXT92508.1; -; Genomic_RNA. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro. DR CDD; cd21593; HCoV_HKU1-like_RdRp; 1. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR044863; NIRAN. DR InterPro; IPR047570; NSP12_IF_CoV. DR InterPro; IPR046441; RdRp_CoV. DR InterPro; IPR044347; RdRp_HCoV_HKU1-like. DR InterPro; IPR009469; RdRp_N_CoV. DR InterPro; IPR001205; RNA-dir_pol_C. DR Pfam; PF06478; CoV_RPol_N; 1. DR Pfam; PF00680; RdRP_1; 1. DR SUPFAM; SSF56672; DNA/RNA polymerases; 1. DR PROSITE; PS52000; COV_NSP12_IF; 1. DR PROSITE; PS51948; COV_NSP12_RDRP; 1. DR PROSITE; PS51947; NIRAN; 1. PE 3: Inferred from homology; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484, KW ECO:0000313|EMBL:AXT92508.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 6..261 FT /note="NiRAN" FT /evidence="ECO:0000259|PROSITE:PS51947" FT DOMAIN 262..360 FT /note="Nsp12 Interface" FT /evidence="ECO:0000259|PROSITE:PS52000" FT DOMAIN 361..928 FT /note="Nsp12 RNA-dependent RNA polymerase" FT /evidence="ECO:0000259|PROSITE:PS51948" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AXT92508.1" FT NON_TER 928 FT /evidence="ECO:0000313|EMBL:AXT92508.1" SQ SEQUENCE 928 AA; 106606 MW; 92CA998C25C10850 CRC64; SKDLNFLNRV RGTSVNARLV PCASGLSTDV QLRAFDICNT NRAGIGLYYK VNCCRFQRID DDGNKLDKFF VVKRTNLEVY NKEKTYYELI KSCGVVAEHD FFTFDIDGSR VPHIVRRNLS KYTMLDLCYA LRHFDRNDCS ILCEILCEYA DCKESYFSKK DWYDFVENPD IINIYKKLGP IFNRALLNTV IFADTLVEVG LVGVLTLDNQ DLYGQWYDFG DFIQTAPGFG VAVADSYYSY MMPMLTMCHV LDCELFVNDS YRQFDLVQYD FTDYKLELFN KYFKYWGMKY HPNTVDCDND RCIIHCANFN ILFSMVLPNT CFGPLVRQIF VDGVPFVVSI GYHYKELGVV MNLDVDTHRY RLSLKDLLLY AADPAMHVAS ASALLDLRTC CFSVAAITSG IKFQTVKPGN FNQDFYEFVK SKGLFKEGST VDLKHFFFTQ DGNAAITDYN YYKYNLPTMV DIKQLLFVLE VVYKYFEIYD GGCIPASQVI VNNYDKSAGY PFNKFGKARL YYEALSFEEQ NEIYAYTKRN VLPTLTQMNL KYAISAKNRA RTVAGVSILS TMTGRMFHQK CLKSIAATRG VPVVIGTTKF YGGWDDMLRH LIKDVDNPVL MGWDYPKCDR AMPNILRIVS SLVLARKHEF CCSHGDRFYR LANECAQVLS EIVMCGGCYY VKPGGTSSGD ATTAFANSVF NICQAVTANV CSLMACNGHK IEDLSIRNLQ KRLYSNVYRT DYVDYTFVNE YYEFLCKHFS MMILSDDGVV CYNSDYASKG YIANISVFQQ VLYYQNNVFM SESKCWVEND ITNGPHEFCS QHTMLVKIDG DYVYLPYPDP SRILGAGCFV DDLLKTDSVL LIERFVSLAI DAYPLVYHEN EEYQKVFRVY LEYIKKLYND LGTQILDSYS VILSTCDGLK FTEESFYKNM YLKSAVMQ //