ID A0A7C3VSP8_9RHOB Unreviewed; 284 AA. AC A0A7C3VSP8; DT 02-DEC-2020, integrated into UniProtKB/TrEMBL. DT 02-DEC-2020, sequence version 1. DT 27-NOV-2024, entry version 16. DE RecName: Full=N-acetylmuramic acid 6-phosphate etherase {ECO:0000256|HAMAP-Rule:MF_00068}; DE Short=MurNAc-6-P etherase {ECO:0000256|HAMAP-Rule:MF_00068}; DE EC=4.2.1.126 {ECO:0000256|HAMAP-Rule:MF_00068}; DE AltName: Full=N-acetylmuramic acid 6-phosphate hydrolase {ECO:0000256|HAMAP-Rule:MF_00068}; DE AltName: Full=N-acetylmuramic acid 6-phosphate lyase {ECO:0000256|HAMAP-Rule:MF_00068}; DE Flags: Fragment; GN Name=murQ {ECO:0000256|HAMAP-Rule:MF_00068, GN ECO:0000313|EMBL:HGG06337.1}; GN ORFNames=ENK28_12840 {ECO:0000313|EMBL:HGG06337.1}; OS Aliiroseovarius sp. OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales; OC Paracoccaceae; Aliiroseovarius. OX NCBI_TaxID=1872442 {ECO:0000313|EMBL:HGG06337.1}; RN [1] {ECO:0000313|EMBL:HGG06337.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HyVt-562 {ECO:0000313|EMBL:HGG06337.1}; RX PubMed=31911466; RA Zhou Z., Liu Y., Xu W., Pan J., Luo Z.H., Li M.; RT "Genome- and Community-Level Interaction Insights into Carbon Utilization RT and Element Cycling Functions of Hydrothermarchaeota in Hydrothermal RT Sediment."; RL mSystems 5:e00795-e00719(2020). CC -!- FUNCTION: Specifically catalyzes the cleavage of the D-lactyl ether CC substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- CC lactate. Together with AnmK, is also required for the utilization of CC anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the CC medium or derived from its own cell wall murein, and thus plays a role CC in cell wall recycling. {ECO:0000256|HAMAP-Rule:MF_00068}. CC -!- CATALYTIC ACTIVITY: CC Reaction=N-acetyl-D-muramate 6-phosphate + H2O = N-acetyl-D-glucosamine CC 6-phosphate + (R)-lactate; Xref=Rhea:RHEA:26410, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:16004, ChEBI:CHEBI:57513, ChEBI:CHEBI:58722; CC EC=4.2.1.126; Evidence={ECO:0000256|HAMAP-Rule:MF_00068}; CC -!- PATHWAY: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate CC degradation. {ECO:0000256|HAMAP-Rule:MF_00068}. CC -!- PATHWAY: Amino-sugar metabolism; N-acetylmuramate degradation. CC {ECO:0000256|HAMAP-Rule:MF_00068}. CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan recycling. CC {ECO:0000256|HAMAP-Rule:MF_00068}. CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00068}. CC -!- MISCELLANEOUS: A lyase-type mechanism (elimination/hydration) is CC suggested for the cleavage of the lactyl ether bond of MurNAc 6- CC phosphate, with the formation of an alpha,beta-unsaturated aldehyde CC intermediate with (E)-stereochemistry, followed by the syn addition of CC water to give product. {ECO:0000256|HAMAP-Rule:MF_00068}. CC -!- SIMILARITY: Belongs to the GCKR-like family. MurNAc-6-P etherase CC subfamily. {ECO:0000256|HAMAP-Rule:MF_00068}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:HGG06337.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DRPQ01000423; HGG06337.1; -; Genomic_DNA. DR AlphaFoldDB; A0A7C3VSP8; -. DR UniPathway; UPA00342; -. DR UniPathway; UPA00343; -. DR UniPathway; UPA00544; -. DR Proteomes; UP000885941; Unassembled WGS sequence. DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter. DR GO; GO:0030246; F:carbohydrate binding; IEA:TreeGrafter. DR GO; GO:0016835; F:carbon-oxygen lyase activity; IEA:UniProtKB-UniRule. DR GO; GO:0019899; F:enzyme binding; IEA:TreeGrafter. DR GO; GO:0004857; F:enzyme inhibitor activity; IEA:TreeGrafter. DR GO; GO:0070095; F:fructose-6-phosphate binding; IEA:TreeGrafter. DR GO; GO:0097175; P:1,6-anhydro-N-acetyl-beta-muramic acid catabolic process; IEA:UniProtKB-UniPathway. DR GO; GO:0046348; P:amino sugar catabolic process; IEA:InterPro. DR GO; GO:0042593; P:glucose homeostasis; IEA:TreeGrafter. DR GO; GO:0097173; P:N-acetylmuramic acid catabolic process; IEA:UniProtKB-UniPathway. DR GO; GO:0033132; P:negative regulation of glucokinase activity; IEA:TreeGrafter. DR GO; GO:0009254; P:peptidoglycan turnover; IEA:UniProtKB-UniRule. DR GO; GO:0009750; P:response to fructose; IEA:TreeGrafter. DR CDD; cd05007; SIS_Etherase; 1. DR FunFam; 3.40.50.10490:FF:000014; N-acetylmuramic acid 6-phosphate etherase; 1. DR Gene3D; 1.10.8.1080; -; 1. DR HAMAP; MF_00068; MurQ; 1. DR InterPro; IPR005488; Etherase_MurQ. DR InterPro; IPR005486; Glucokinase_regulatory_CS. DR InterPro; IPR040190; MURQ/GCKR. DR InterPro; IPR000408; Reg_chr_condens. DR InterPro; IPR001347; SIS_dom. DR InterPro; IPR046348; SIS_dom_sf. DR NCBIfam; TIGR00274; N-acetylmuramic acid 6-phosphate etherase; 1. DR PANTHER; PTHR10088; GLUCOKINASE REGULATORY PROTEIN; 1. DR PANTHER; PTHR10088:SF4; GLUCOKINASE REGULATORY PROTEIN; 1. DR Pfam; PF22645; GKRP_SIS_N; 1. DR SUPFAM; SSF53697; SIS domain; 1. DR PROSITE; PS01272; GCKR; 1. DR PROSITE; PS50012; RCC1_3; 1. DR PROSITE; PS51464; SIS; 1. PE 3: Inferred from homology; KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277, ECO:0000256|HAMAP- KW Rule:MF_00068}; KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00068}. FT DOMAIN 36..199 FT /note="SIS" FT /evidence="ECO:0000259|PROSITE:PS51464" FT ACT_SITE 64 FT /note="Proton donor" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00068" FT ACT_SITE 95 FT /evidence="ECO:0000256|HAMAP-Rule:MF_00068" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:HGG06337.1" SQ SEQUENCE 284 AA; 29150 MW; 20B00ED8447ED632 CRC64; GLSGAEIATL MNDEDKKVTR AVQDVLAPIG QAIEAAARTL RSGGRVIYIG AGTSGRLGVL DASEIPPTFS APPDMIIGVI AGGRDAMFVA REGAEDDPEQ GKGDLAALSL TKNDFVVGLA ASGRTPYVLG AIAFARATGA TTAGISCNAD SPLDRACDIP ITPVVGPEIL TGSTRLKSGT AQKQILNMIS TGAMVRLGKC FGNRMVDLNA SNDKLKARAI NLVADLAPTG KPAAHMALVA AKWDIKTAIL TERTGLSVTE AAKLIRDSNG HLRRAIAAAE GNAP //