ID A0A6P5W1Y1_DROOB Unreviewed; 742 AA. AC A0A6P5W1Y1; DT 02-DEC-2020, integrated into UniProtKB/TrEMBL. DT 02-DEC-2020, sequence version 1. DT 14-DEC-2022, entry version 8. DE SubName: Full=polycystin-2 {ECO:0000313|RefSeq:XP_022231378.1}; GN Name=LOC111080207 {ECO:0000313|RefSeq:XP_022231378.1}; OS Drosophila obscura (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7282 {ECO:0000313|Proteomes:UP000515133, ECO:0000313|RefSeq:XP_022231378.1}; RN [1] {ECO:0000313|RefSeq:XP_022231378.1} RP IDENTIFICATION. RC STRAIN=14011-0151.01 {ECO:0000313|RefSeq:XP_022231378.1}; RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the polycystin family. CC {ECO:0000256|ARBA:ARBA00007200}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_022231378.1; XM_022375686.1. DR AlphaFoldDB; A0A6P5W1Y1; -. DR OMA; DANMFSV; -. DR Proteomes; UP000515133; Unplaced. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR InterPro; IPR013122; PKD1_2_channel. DR InterPro; IPR003915; PKD_2. DR InterPro; IPR046791; Polycystin_dom. DR Pfam; PF08016; PKD_channel; 1. DR Pfam; PF20519; Polycystin_dom; 1. DR PRINTS; PR01433; POLYCYSTIN2. PE 3: Inferred from homology; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 6..24 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 36..52 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 122..145 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 370..392 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 404..425 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 457..474 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 494..517 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 561..587 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 165..361 FT /note="Polycystin_dom" FT /evidence="ECO:0000259|Pfam:PF20519" FT DOMAIN 366..588 FT /note="PKD_channel" FT /evidence="ECO:0000259|Pfam:PF08016" FT REGION 723..742 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 742 AA; 86474 MW; 6D8C480AD946518D CRC64; MASNVIFIVT LCIFSVCFVT IWKYSGMEHE DRKFKAILIT FFMVMLFQFL VFDPLRFLVL AIDAACWPRL QRPPVPDPEA KRHTRMDYLK LRLRSLRSQL LITEKHRNEE LNLKYRTIVR ELWVYGKLFL IHLFLNLALV NRLLYYNGES IENLMKYNHT DSIGLSNVLF LHQLYPFIEH TLINGFLNND HHRLTSHWNH VNSTQLVGVI QMRLLRDTGE HYGLSDPEYT KKEYSEGWSL PNVREPYTNK YWSIYLPWLP MSKNYSFFEK FFLSIRQYGY FAMYPELTGY ATTLRNTRKD SIKVLEYLYE KNWLDQRTAA LFLDFTLYNV DANMFSVITL RFENLPYGII HSSMYVNSVS LTESAETLPW FGMICLFAYV IIWLELGMTV IVPLWFEPKR LKLFWVKIDL AILLLSMIVV TLMAMRDGVV SRLLAVLEMS NTLDFIDFRI PARMTEFTVI LMGFLVCLVT LRLWKVMQFS SIFQVFTMTL SLAWQALFST ACVIGIFMMG FGIATVCING NNSDNFRSLL QGMATVMCFS FGFTSHVAPK DLFHGGLWMG ILIYGIMSFT IAILLTNVFV SILNNYFTAA KAVRDRKRKD QISFWEFLCV EYADIIRTVR EAFGCEHKYR RKNRTVAENI KHTMDLQAAA VASARFKRGK GHKSSIKLKG GVVTDDEAEE HERKAQAQHK DRIARTYTIA AILQTQMEIA ERTLFGDKEG NLLGEDENDL HEQVPDLPRQ YV //