ID A0A6P4H8P7_DROTK Unreviewed; 422 AA. AC A0A6P4H8P7; DT 02-DEC-2020, integrated into UniProtKB/TrEMBL. DT 02-DEC-2020, sequence version 1. DT 03-AUG-2022, entry version 8. DE RecName: Full=Dynamin GTPase {ECO:0000256|ARBA:ARBA00011980}; DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980}; GN Name=LOC108064033 {ECO:0000313|RefSeq:XP_017006851.1}; OS Drosophila takahashii (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=29030 {ECO:0000313|Proteomes:UP000515206, ECO:0000313|RefSeq:XP_017006851.1}; RN [1] {ECO:0000313|RefSeq:XP_017006851.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5; CC Evidence={ECO:0000256|ARBA:ARBA00001837}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_017006851.1; XM_017151362.1. DR GeneID; 108064033; -. DR Proteomes; UP000515206; Unplaced. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0003924; F:GTPase activity; IEA:InterPro. DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW. DR GO; GO:0000266; P:mitochondrial fission; IEA:InterPro. DR GO; GO:0016559; P:peroxisome fission; IEA:InterPro. DR InterPro; IPR030556; DNM1L. DR InterPro; IPR022812; Dynamin. DR InterPro; IPR000375; Dynamin_stalk. DR InterPro; IPR003130; GED. DR InterPro; IPR020850; GED_dom. DR PANTHER; PTHR11566; PTHR11566; 1. DR PANTHER; PTHR11566:SF39; PTHR11566:SF39; 1. DR Pfam; PF01031; Dynamin_M; 1. DR Pfam; PF02212; GED; 1. DR SMART; SM00302; GED; 1. DR PROSITE; PS51388; GED; 1. PE 4: Predicted; KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128}. FT DOMAIN 330..421 FT /note="GED" FT /evidence="ECO:0000259|PROSITE:PS51388" FT REGION 207..303 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 207..277 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 285..301 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 422 AA; 47961 MW; 93EE48D06A1721C0 CRC64; MATQFQSLLN SYGEDVSDKS QTLLQIITKF ASAYCSTIEG TARNIETTEL CGGARICYIF HETFGRTLDS IHPLAGLSKM DILTAIRNAT GPRPALFVPE VSFELLVKRQ IRRLEEPSLR CVELIHEEMQ RIVQHCGNEV QQEMLRFPKL HEKIVDVVTQ LLRRRLPHTN VMVENIVAIE LAYINTKHPD FHKDAALVPS LLKSDSDPYS QINLGQRRAN TPRNHMSPQV SAHSAASQQP QQQQNNQQQQ YSEAHDQNHV GENSTPSMAS TWLSNILPPA PTRPDSIENS ASNTPVHNNM VSPVKPVNLL PDVPANHNPR RLTDKEQKDC DVIERLIKSY FYIVRKSIQD SVPKAIMHFL VNYVKDNLQS ELVTHLYKSD RAETLLNESD HIAVRRKEAA DMLKALTRAN HIISEIRETH MW //