ID A0A6P4GKC1_DROTK Unreviewed; 540 AA. AC A0A6P4GKC1; DT 02-DEC-2020, integrated into UniProtKB/TrEMBL. DT 02-DEC-2020, sequence version 1. DT 03-AUG-2022, entry version 7. DE SubName: Full=insulin gene enhancer protein isl-1 {ECO:0000313|RefSeq:XP_017001709.1}; GN Name=LOC108060510 {ECO:0000313|RefSeq:XP_017001709.1}; OS Drosophila takahashii (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=29030 {ECO:0000313|Proteomes:UP000515206, ECO:0000313|RefSeq:XP_017001709.1}; RN [1] {ECO:0000313|RefSeq:XP_017001709.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, CC ECO:0000256|RuleBase:RU000682}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_017001709.1; XM_017146220.1. DR GeneID; 108060510; -. DR Proteomes; UP000515206; Unplaced. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd00086; homeodomain; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR001781; Znf_LIM. DR Pfam; PF00046; Homeodomain; 1. DR Pfam; PF00412; LIM; 2. DR SMART; SM00389; HOX; 1. DR SMART; SM00132; LIM; 2. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS00478; LIM_DOMAIN_1; 1. DR PROSITE; PS50023; LIM_DOMAIN_2; 2. PE 4: Predicted; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE- KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE- KW ProRule:PRU00108}; Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}. FT DOMAIN 52..114 FT /note="LIM zinc-binding" FT /evidence="ECO:0000259|PROSITE:PS50023" FT DOMAIN 115..177 FT /note="LIM zinc-binding" FT /evidence="ECO:0000259|PROSITE:PS50023" FT DOMAIN 239..299 FT /note="Homeobox" FT /evidence="ECO:0000259|PROSITE:PS50071" FT DNA_BIND 241..300 FT /note="Homeobox" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108" FT REGION 178..247 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 388..450 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 462..491 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 178..222 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 223..238 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 399..419 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 420..450 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 462..483 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 540 AA; 58429 MW; 2F56D6ECA103E21C CRC64; MVMAEIGGHL AHQLPLHNHN HNQTGLQPSL VMNHHLDLDC HGHDVIKKQR LSHCVGCGGQ IHDQYILRVA PDLEWHAACL KCQECRQFLD ESCTCFVRDG KTYCKRDYVR LFGTKCDKCG NSFSKNDFVM RAKTKIFHIE CFRCSACARQ LLPGDEFALR DAGALYCKED HDVLEKSSQS SLTSSSVESN NNISSSNNNN TNLSNNNHSS ELGSMSDSGS ESGSHKSIRE KRPSGPSDGK PTRVRTVLNE KQLHTLRTCY NANPRPDALM KEQLVEMTSL SPRVIRVWFQ NKRCKDKKKT IQMKLQMQQE KEGRKLGYGA MQGIPMIASS PVRHDSPLNL QGLDVQTYQP PWKALSDFAL HADLDSNGAI NTHTPAFQQL VNQMHGYDLN GMPILPHPHS HPAQGPPHQH PPPPGGPHNH QNQQPNQQPG GSSLDSGITS HHHPDSTDSY VTYLESDDKS KLALTPSSSS SASAGTSISS PPSGVGAGGG GGGGAVGGGA GVLGLGVGVG VVANQSATEQ LMQMLQKVTG SASPASHAVL //