ID A0A6P3TA66_SHEEP Unreviewed; 587 AA. AC A0A6P3TA66; B3F206; DT 02-DEC-2020, integrated into UniProtKB/TrEMBL. DT 02-DEC-2020, sequence version 1. DT 03-AUG-2022, entry version 8. DE SubName: Full=Cryptochrome-1 {ECO:0000313|EMBL:ABS44879.1, ECO:0000313|RefSeq:NP_001123207.1}; DE SubName: Full=cryptochrome-1 isoform X1 {ECO:0000313|RefSeq:XP_012014825.2, ECO:0000313|RefSeq:XP_012014834.2}; GN Name=CRY1 {ECO:0000313|RefSeq:NP_001123207.1, GN ECO:0000313|RefSeq:XP_012014825.2, ECO:0000313|RefSeq:XP_012014834.2}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|RefSeq:XP_012014825.2}; RN [1] {ECO:0000313|RefSeq:NP_001123207.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12374857; DOI=10.1073/pnas.212517599; RA Lincoln G., Messager S., Andersson H., Hazlerigg D.; RT "Temporal expression of seven clock genes in the suprachiasmatic nucleus RT and the pars tuberalis of the sheep: evidence for an internal coincidence RT timer."; RL Proc. Natl. Acad. Sci. U.S.A. 99:13890-13895(2002). RN [2] {ECO:0000313|EMBL:ABS44879.1, ECO:0000313|RefSeq:NP_001123207.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=18953409; DOI=10.1371/journal.pone.0003530; RA Dardente H., Mendoza J., Fustin J.M., Challet E., Hazlerigg D.G.; RT "Implication of the F-Box Protein FBXL21 in circadian pacemaker function in RT mammals."; RL PLoS ONE 3:E3530-E3530(2008). RN [3] {ECO:0000313|EMBL:ABS44879.1, ECO:0000313|RefSeq:NP_001123207.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=19341811; DOI=10.1016/j.cbpa.2009.03.016; RA Dardente H., Fustin J.M., Hazlerigg D.G.; RT "Transcriptional feedback loops in the ovine circadian clock."; RL Comp. Biochem. Physiol. 153:391-398(2009). RN [4] {ECO:0000313|RefSeq:NP_001123207.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=19150926; RA Fustin J.M., O'Neill J.S., Hastings M.H., Hazlerigg D.G., Dardente H.; RT "Cry1 circadian phase in vitro: wrapped up with an E-box."; RL J. Biol. Rhythms 24:16-24(2009). RN [5] {ECO:0000313|RefSeq:NP_001123207.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=23598442; RA West A., Dupre S.M., Yu L., Paton I.R., Miedzinska K., McNeilly A.S., RA Davis J.R., Burt D.W., Loudon A.S.; RT "Npas4 is activated by melatonin, and drives the clock gene Cry1 in the RT ovine pars tuberalis."; RL Mol. Endocrinol. 27:979-989(2013). RN [6] {ECO:0000313|RefSeq:NP_001123207.1, ECO:0000313|RefSeq:XP_012014825.2} RP IDENTIFICATION. RC STRAIN=OAR_USU_Benz2616 {ECO:0000313|RefSeq:XP_012014825.2, RC ECO:0000313|RefSeq:XP_012014834.2}; RC TISSUE=Blood {ECO:0000313|RefSeq:XP_012014825.2, RC ECO:0000313|RefSeq:XP_012014834.2}; RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- COFACTOR: CC Name=FAD; Xref=ChEBI:CHEBI:57692; CC Evidence={ECO:0000256|ARBA:ARBA00001974}; CC -!- SIMILARITY: Belongs to the DNA photolyase class-1 family. CC {ECO:0000256|ARBA:ARBA00005862}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EF494243; ABS44879.1; -; mRNA. DR RefSeq; NP_001123207.1; NM_001129735.1. DR RefSeq; XP_012014825.1; XM_012159435.2. DR RefSeq; XP_012014825.2; XM_012159435.3. DR RefSeq; XP_012014834.1; XM_012159444.2. DR RefSeq; XP_012014834.2; XM_012159444.3. DR GeneID; 443263; -. DR KEGG; oas:443263; -. DR CTD; 1407; -. DR OrthoDB; 378952at2759; -. DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl. DR GO; GO:0005634; C:nucleus; IEA:Ensembl. DR GO; GO:0070888; F:E-box binding; IEA:Ensembl. DR GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl. DR GO; GO:0016922; F:nuclear receptor binding; IEA:Ensembl. DR GO; GO:0019902; F:phosphatase binding; IEA:Ensembl. DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW. DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl. DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:Ensembl. DR GO; GO:0006975; P:DNA damage induced protein phosphorylation; IEA:Ensembl. DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IEA:Ensembl. DR GO; GO:0006094; P:gluconeogenesis; IEA:Ensembl. DR GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl. DR GO; GO:0019915; P:lipid storage; IEA:Ensembl. DR GO; GO:0042754; P:negative regulation of circadian rhythm; IEA:Ensembl. DR GO; GO:0045744; P:negative regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl. DR GO; GO:2000323; P:negative regulation of glucocorticoid receptor signaling pathway; IEA:Ensembl. DR GO; GO:2000850; P:negative regulation of glucocorticoid secretion; IEA:Ensembl. DR GO; GO:0045721; P:negative regulation of gluconeogenesis; IEA:Ensembl. DR GO; GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl. DR GO; GO:2000001; P:regulation of DNA damage checkpoint; IEA:Ensembl. DR GO; GO:0014823; P:response to activity; IEA:Ensembl. DR GO; GO:0033762; P:response to glucagon; IEA:Ensembl. DR GO; GO:0032868; P:response to insulin; IEA:Ensembl. DR Gene3D; 3.40.50.620; -; 1. DR InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf. DR InterPro; IPR036155; Crypto/Photolyase_N_sf. DR InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd. DR InterPro; IPR002081; Cryptochrome/DNA_photolyase_1. DR InterPro; IPR006050; DNA_photolyase_N. DR InterPro; IPR014729; Rossmann-like_a/b/a_fold. DR PANTHER; PTHR11455; PTHR11455; 1. DR Pfam; PF00875; DNA_photolyase; 1. DR Pfam; PF03441; FAD_binding_7; 1. DR SUPFAM; SSF48173; SSF48173; 1. DR SUPFAM; SSF52425; SSF52425; 1. DR PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1. PE 2: Evidence at transcript level; KW Chromophore {ECO:0000256|ARBA:ARBA00022991}; KW FAD {ECO:0000256|ARBA:ARBA00022827}; KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630}; KW Photoreceptor protein {ECO:0000256|ARBA:ARBA00022543}; KW Receptor {ECO:0000256|ARBA:ARBA00022543}; KW Sensory transduction {ECO:0000256|ARBA:ARBA00022543}. FT DOMAIN 3..132 FT /note="Photolyase/cryptochrome alpha/beta" FT /evidence="ECO:0000259|PROSITE:PS51645" FT REGION 546..587 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 587 AA; 66454 MW; 4EEA4025338CE66D CRC64; MGVNAVHWFR KGLRLHDNPA LKECIQGADT IRCVYILDPW FAGSSNVGIN RWRFLLQCLE DLDANLRKLN SRLFVIRGQP ADVFPRLFKE WNITKLSIEY DSEPFGKERD AAIKKLATEA GVEVIIRISH TLYDLDKIIE LNGGQPPLTY KRFQTLISKM EPLEIPVETI TSEVMEKCTT PLSDDHDEKY GVPSLEELGF DTDGLPSAVW PGGETEALTR LERHLERKAW VANFERPRMN ANSLLASPTG LSPYLRFGCL SCRLFYFKLT DLYKKVKKNS SPPLSLYGQL LWREFFYTAA TNNPRFDKME GNPICVQIPW DKNPEALAKW AEGRTGFPWI DAIMTQLRQE GWIHHLARHA VACFLTRGDL WISWEEGMKV FEELLLDADW SINAGSWMWL SCSSFFQQFF HCYCPVGFGR RTDPNGDYIR RYLPVLRGFP AKYIYDPWNA PEGIQKVAKC LIGVNYPKPM VNHAEASRLN IERMKQIYQQ LSRYRGLGLL ASVPSNPNGN GGLMGYSPGE NIPGCSSSAS CTQGSGILHY AHGDSQQTHL LKQGRSSTAA GLGSGKRPSQ EEDTQSVGPK VQRQSTN //