ID A0A6P3IR59_BISBB Unreviewed; 379 AA. AC A0A6P3IR59; DT 02-DEC-2020, integrated into UniProtKB/TrEMBL. DT 02-DEC-2020, sequence version 1. DT 24-JUL-2024, entry version 17. DE SubName: Full=Tumor susceptibility gene 101 protein {ECO:0000313|RefSeq:XP_010856776.1}; GN Name=TSG101 {ECO:0000313|RefSeq:XP_010856776.1}; OS Bison bison bison (North American plains bison). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bison. OX NCBI_TaxID=43346 {ECO:0000313|Proteomes:UP000515208, ECO:0000313|RefSeq:XP_010856776.1}; RN [1] {ECO:0000313|RefSeq:XP_010856776.1} RP IDENTIFICATION. RC TISSUE=Blood {ECO:0000313|RefSeq:XP_010856776.1}; RG RefSeq; RL Submitted (APR-2024) to UniProtKB. CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UEV CC subfamily. {ECO:0000256|ARBA:ARBA00009594}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_010856776.1; XM_010858474.1. DR AlphaFoldDB; A0A6P3IR59; -. DR GeneID; 105002031; -. DR KEGG; bbis:105002031; -. DR CTD; 7251; -. DR OrthoDB; 37962at2759; -. DR Proteomes; UP000515208; Unplaced. DR GO; GO:0000813; C:ESCRT I complex; IEA:TreeGrafter. DR GO; GO:0043130; F:ubiquitin binding; IEA:TreeGrafter. DR GO; GO:0008333; P:endosome to lysosome transport; IEA:TreeGrafter. DR GO; GO:0036211; P:protein modification process; IEA:InterPro. DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule. DR CDD; cd00890; Prefoldin; 1. DR Gene3D; 6.10.140.820; -; 1. DR Gene3D; 6.10.250.370; -; 1. DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1. DR InterPro; IPR052070; ESCRT-I_UEV_domain. DR InterPro; IPR037202; ESCRT_assembly_dom. DR InterPro; IPR017916; SB_dom. DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD. DR InterPro; IPR008883; UEV_N. DR PANTHER; PTHR23306:SF17; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN; 1. DR PANTHER; PTHR23306; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED; 1. DR Pfam; PF05743; UEV; 1. DR Pfam; PF09454; Vps23_core; 1. DR SMART; SM00212; UBCc; 1. DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1. DR SUPFAM; SSF54495; UBC-like; 1. DR PROSITE; PS51312; SB; 1. DR PROSITE; PS51322; UEV; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}; KW Endosome {ECO:0000256|ARBA:ARBA00022753}; KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|PROSITE- KW ProRule:PRU00644}; Reference proteome {ECO:0000313|Proteomes:UP000515208}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PROSITE- KW ProRule:PRU00644}. FT DOMAIN 1..133 FT /note="UEV" FT /evidence="ECO:0000259|PROSITE:PS51322" FT DOMAIN 311..379 FT /note="SB" FT /evidence="ECO:0000259|PROSITE:PS51312" FT REGION 183..209 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 228..300 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 184..209 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 379 AA; 42809 MW; 2C685495837C860C CRC64; MKYKYRDLTV RETVNVISLY KDLKPVLDSY VFNDGSSREL MNLTGTIPVP YRGNTYNIPI CLWLLDTYPY NPPICFVKPT SSMTIKTGKH VDANGKIYLP YLHEWKHPQS DLLGLIQVMI VVFGDEPPVF SRPTVSASYP PYQATGPPNT SYMPGMPSGI SAYPSGYPPN PSGYTGCPYP PGGQYPATTS SQYPSQPPVT TVGPSRDGTI SEDTIRASLI SAVSDKLRWR MKEEMDRAQA ELNALKRTEE DLKKGHQKLE EMVNRLDQEV AEVDKNIELL RKKDEELSSA LEKMENQSEN NDIDEVIIPT APLYKQILNL YAEENAIEDT IFYLGEALRR GVIDLDVFLK HVRLLSRKQF QLRALMQKAR KTAGLSDLY //