ID   A0A6P3I767_BISBB        Unreviewed;       224 AA.
AC   A0A6P3I767;
DT   02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   RecName: Full=Beta-casein {ECO:0000256|ARBA:ARBA00018977, ECO:0000256|PIRNR:PIRNR002372};
GN   Name=CSN2 {ECO:0000313|RefSeq:XP_010850446.1};
OS   Bison bison bison (North American plains bison).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bison.
OX   NCBI_TaxID=43346 {ECO:0000313|Proteomes:UP000515208, ECO:0000313|RefSeq:XP_010850446.1};
RN   [1] {ECO:0000313|RefSeq:XP_010850446.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_010850446.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Important role in determination of the surface properties of
CC       the casein micelles. {ECO:0000256|ARBA:ARBA00002287,
CC       ECO:0000256|PIRNR:PIRNR002372}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the beta-casein family.
CC       {ECO:0000256|ARBA:ARBA00008083, ECO:0000256|PIRNR:PIRNR002372}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_010850446.1; XM_010852144.1.
DR   AlphaFoldDB; A0A6P3I767; -.
DR   SMR; A0A6P3I767; -.
DR   GeneID; 104997418; -.
DR   KEGG; bbis:104997418; -.
DR   CTD; 1447; -.
DR   OrthoDB; 4933674at2759; -.
DR   Proteomes; UP000515208; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001588; Casein.
DR   InterPro; IPR016345; Casein_beta.
DR   InterPro; IPR031305; Casein_CS.
DR   PANTHER; PTHR11500; BETA CASEIN; 1.
DR   PANTHER; PTHR11500:SF0; BETA-CASEIN; 1.
DR   Pfam; PF00363; Casein; 1.
DR   PIRSF; PIRSF002372; Beta-casein; 1.
DR   PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Milk protein {ECO:0000256|ARBA:ARBA00022743,
KW   ECO:0000256|PIRNR:PIRNR002372};
KW   Reference proteome {ECO:0000313|Proteomes:UP000515208};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..224
FT                   /note="Beta-casein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5027672173"
FT   COILED          31..58
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   224 AA;  25107 MW;  F0BBDD8148A238AE CRC64;
     MKVLILACLV ALALARELEE LNVPGEIVES LSSSEESITR INKKIEKFQS EEQQQTEDEL
     QDKIHPFAQT QSLVYPFPGP IPNSLPQNIP PLTQTPVVVP PFLQPEVMGV SKVKEAMAPK
     HKEMPFPKYP VEPFTESQSL TLTDVENLHL PLPLLQSWMH QPHQPLPPTV MFPPQSVLSL
     SQSKVLPVPQ KAVPYPQRDM PIQAFLLYQE PVLGPVRGPF PIIV
//