ID A0A6P3ECN2_SHEEP Unreviewed; 400 AA. AC A0A6P3ECN2; DT 02-DEC-2020, integrated into UniProtKB/TrEMBL. DT 02-DEC-2020, sequence version 1. DT 19-JAN-2022, entry version 6. DE SubName: Full=dual specificity mitogen-activated protein kinase kinase 2 isoform X1 {ECO:0000313|RefSeq:XP_004008652.2}; GN Name=MAP2K2 {ECO:0000313|RefSeq:XP_004008652.2}; GN ORFNames=JEQ12_016473 {ECO:0000313|EMBL:KAG5208908.1}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Proteomes:UP000515149, ECO:0000313|RefSeq:XP_004008652.2}; RN [1] {ECO:0000313|EMBL:KAG5208908.1, ECO:0000313|Proteomes:UP000664991} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Heart {ECO:0000313|EMBL:KAG5208908.1}; RA Li X.; RT "De novo assembly of Tibetan sheep genome."; RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|RefSeq:XP_004008652.2} RP IDENTIFICATION. RC STRAIN=OAR_USU_Benz2616 {ECO:0000313|RefSeq:XP_004008652.2}; RC TISSUE=Blood {ECO:0000313|RefSeq:XP_004008652.2}; RG RefSeq; RL Submitted (FEB-2021) to UniProtKB. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CC {ECO:0000256|RuleBase:RU000304}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JAEMGP010000005; KAG5208908.1; -; Genomic_DNA. DR RefSeq; XP_004008652.2; XM_004008603.4. DR KEGG; oas:101113846; -. DR OMA; ATQELPW; -. DR Proteomes; UP000515149; Genome assembly. DR Proteomes; UP000664991; Unassembled WGS sequence. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR Pfam; PF00069; Pkinase; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils}; KW Kinase {ECO:0000313|RefSeq:XP_004008652.2}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU10141}; KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304}; KW Transferase {ECO:0000313|RefSeq:XP_004008652.2}. FT DOMAIN 72..369 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT REGION 286..310 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 34..57 FT /evidence="ECO:0000256|SAM:Coils" FT BINDING 101 FT /note="ATP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141" SQ SEQUENCE 400 AA; 44502 MW; FF7CDABD0A943BD4 CRC64; MLARRKPVLP ALTINPAIAE GPSPTSEGAS EAHLVDLQKK LEELELDEQQ KKRLEAFLTQ KAKVGELKDD DFERISELGA GNGGVVTKVQ HRPSGLIMAR KLIHLEIKPA IRNQIIRELQ VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMSPERLQ GTHYSVQSDI WSMGLSLVEL SIGRYPIPPP DAKELEAIFG RPMVDGAEGE PPSISPRPRP PGRPISGHGM DSRPAMAIFE LLDYIVNEPP PKLPNGVFTQ DFQEFVNKCL IKNPAERADL KMLMNHTFIK RSEVEEVDFA GWLCKTLRLN QPSTPTRTAV //