ID A0A6P3D4E2_IXOSC Unreviewed; 565 AA. AC A0A6P3D4E2; DT 02-DEC-2020, integrated into UniProtKB/TrEMBL. DT 02-DEC-2020, sequence version 1. DT 19-JAN-2022, entry version 6. DE SubName: Full=major facilitator superfamily domain-containing protein 6 {ECO:0000313|RefSeq:XP_002434736.2}; GN Name=LOC8053841 {ECO:0000313|RefSeq:XP_002434736.2}; OS Ixodes scapularis (Black-legged tick) (Deer tick). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari; OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes. OX NCBI_TaxID=6945 {ECO:0000313|Proteomes:UP000515155, ECO:0000313|RefSeq:XP_002434736.2}; RN [1] {ECO:0000313|RefSeq:XP_002434736.2} RP IDENTIFICATION. RC TISSUE=Cell clone derived {ECO:0000313|RefSeq:XP_002434736.2}; RG RefSeq; RL Submitted (FEB-2021) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family. CC {ECO:0000256|ARBA:ARBA00005241}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_002434736.2; XM_002434691.2. DR OMA; ANGYANE; -. DR Proteomes; UP000515155; Genome assembly. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 1.20.1250.20; -; 3. DR InterPro; IPR024989; MFS_assoc_dom. DR InterPro; IPR036259; MFS_trans_sf. DR Pfam; PF12832; MFS_1_like; 1. DR SUPFAM; SSF103473; SSF103473; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 21..44 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 50..73 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 85..107 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 222..251 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 263..283 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 295..316 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 337..360 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 372..395 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 402..420 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 432..451 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 463..485 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 497..516 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 21..494 FT /note="MFS_1_like" FT /evidence="ECO:0000259|Pfam:PF12832" FT REGION 535..565 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 565 AA; 61246 MW; 6EAC51BC4029B413 CRC64; MTIKENVSRL SRYVVPNLEL LPLKIHMFLY FGAAVGVMPF ATVIAKQLGI SASLVGMLNT ALLFASVVMR FLVGSLTDKA QRLKIILIVV ISIESFFHFM IIVVPPITPT KLSVRTTSPE CRSQNTTMHI CFTEELPNDC SGADTSDCTL SCTHTTLNST SGGKLEIPFS SSNMCGIKTW CAPLETKDQK DSHDMFCAAE NRTCNASCLA ADQPSTIRTS TFWLYVVFRV VAGIAFGVGI SLTDAATYAI LRDRKEDYGK QRLWGTIGWG GLAPLVGYLN QMATGGSSFT DYSPGFYMLA ALAVMDVLGL VFLEVPRSPM SKQLLKDLSE VFVNVRTLFF TFAVFNMGFL MGFIWTYGLW YLEELGATPQ LLGANLAVQC FGGEVPVLFF SGWIIRKIGY GNAVSLSIGG LALRFAVYSY GSDVWAMLPV EVTHGLCFGL FYAALTSYAS TAAPPGTEAT MQGILGGTFE GLGIASGTLV AGHLYDYVGG RTTCRIYLAY CVVFLVLHVA VDCALARMEA MRAKDSTIAR ASANMASDNE TTLPLNPSKE GESLEAHLQP LDQDV //