ID A0A6M5UKK1_MOUSE Unreviewed; 776 AA. AC A0A6M5UKK1; DT 07-OCT-2020, integrated into UniProtKB/TrEMBL. DT 07-OCT-2020, sequence version 1. DT 24-JAN-2024, entry version 11. DE SubName: Full=Breast and ovarian cancer susceptibility protein {ECO:0000313|EMBL:QJW38984.1}; DE Flags: Fragment; GN Name=Brca1 {ECO:0000313|EMBL:QJW38984.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:QJW38984.1}; RN [1] {ECO:0000313|EMBL:QJW38984.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=32392190; RA Bogdanov A.S., Maltsev A.N., Kotenkova E.V., Malikov V.G., Lissovsky A.A., RA Stakheev V.V., Darvish J., Castiglia R.; RT "[Variability of Fragments of Nuclear Brca1 Gene, Exon 11, and RT Mitochondrial Cox1 Gene in House Mice Mus musculus]."; RL Mol. Biol. (Mosk.) 54:212-223(2020). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MN228616; QJW38984.1; -; Genomic_DNA. DR GO; GO:0005634; C:nucleus; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006281; P:DNA repair; IEA:InterPro. DR InterPro; IPR011364; BRCA1. DR InterPro; IPR031099; BRCA1-associated. DR InterPro; IPR025994; BRCA1_serine_dom. DR PANTHER; PTHR13763:SF0; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN; 1. DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1. DR Pfam; PF12820; BRCT_assoc; 1. DR PIRSF; PIRSF001734; BRCA1; 1. DR PRINTS; PR00493; BRSTCANCERI. PE 4: Predicted; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}. FT DOMAIN 89..250 FT /note="BRCA1 serine-rich" FT /evidence="ECO:0000259|Pfam:PF12820" FT REGION 59..109 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 246..328 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 364..517 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 611..646 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 59..86 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 268..303 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 373..402 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 406..438 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 450..479 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 501..517 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 632..646 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:QJW38984.1" FT NON_TER 776 FT /evidence="ECO:0000313|EMBL:QJW38984.1" SQ SEQUENCE 776 AA; 84572 MW; E1B89688104EDA91 CRC64; HPEKCQSISI SNVCVEPCGT DAHASSLQPE TSSLLLIEDR MNAEKAEFCN KSKQPGIAXS QQSRWAASKG TCNDRQVPST GEKVGPNADS LSDREKWTHP QSLCPENSGA TTDVPWITLN SSVQKVNEWF SRTGEMLTSD SASARRHESN AEAAVVLEVS NEVDGGFSSS RKTDLVTPDP HHTLMCKSGR DFSKPVENNI SDKIFGKSYQ RKGSRPHLNH VTEIIGTFIT EPQITQEQPF TNKLKRKRST SLQPEDFIKK ADXAGVQRTP DNINQGTDXM EPNEQAVSTT SNCQENKIAG SNLQKEKSAH PXESLRKEPA STAGAKSISN SVSDLEVELN VHSSKAPKKN RLRRKSSIRC ALPLEPISRN PSPPTCAELQ IDSCGSSEET KKNHSNQQPA GHLREPQLIE DTEPAADAKK NEPNEHIRKR RASDAFPEEK LMNKAGLLTS CXSPRKSQGP VNPSPQRTGT EQLETXQMSD SAKELGDRVL GGEPSGKTTD RSEESTSVSL VPDTDYDTQN SVSVLDAXTV RYARTGSAQC MTQFVASENP KELVHGSNNA GSGTEGLKPP LRHALNLSQE XVEMEDSELD TQYLQNTFQV SKRQSFALFS KPRSPQKDCA HSVPSKELSP KVTAKGKQKE RQGQEEFEIS HVQAVAATVG LPVPCQEGKL AADTMCDRGS RLCPSSHYRS GENGLSATGK SGISQNSHFK QSVSPIRSSI KTDNRKPLTE GRLRHTSXTE MAVGNENILQ STVHTVSLNN RGNACQEASS GSIHEV //