ID   A0A6M4SRA9_ERYTA        Unreviewed;       451 AA.
AC   A0A6M4SRA9;
DT   07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT   07-OCT-2020, sequence version 1.
DT   02-OCT-2024, entry version 19.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4 {ECO:0000256|ARBA:ARBA00021006, ECO:0000256|RuleBase:RU003297};
DE            EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU003297};
GN   Name=ND4 {ECO:0000313|EMBL:QJS52082.1};
OS   Eryx tataricus (Tartar sand boa).
OG   Mitochondrion {ECO:0000313|EMBL:QJS52082.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Henophidia; Boidae; Erycinae; Eryx.
OX   NCBI_TaxID=51873 {ECO:0000313|EMBL:QJS52082.1};
RN   [1] {ECO:0000313|EMBL:QJS52082.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver {ECO:0000313|EMBL:QJS52082.1};
RA   Cai B., Guo X., Song Z., Jiang J.;
RT   "Next-generation sequencing yields a complete mitochondrial genome of the
RT   Tartar sand boa (Eryx tataricus) from Junggar Basin.";
RL   Mitochondrial DNA Part B Resour 5:731-732(2020).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone.
CC       {ECO:0000256|ARBA:ARBA00003257}.
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity and assembly of complex
CC       I. {ECO:0000256|RuleBase:RU003297}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000766,
CC         ECO:0000256|RuleBase:RU003297};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       membrane {ECO:0000256|ARBA:ARBA00004225,
CC       ECO:0000256|RuleBase:RU003297}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004225, ECO:0000256|RuleBase:RU003297}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4 family.
CC       {ECO:0000256|ARBA:ARBA00009025, ECO:0000256|RuleBase:RU003297}.
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DR   EMBL; MN646174; QJS52082.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A6M4SRA9; -.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR000260; NADH4_N.
DR   InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR   InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   NCBIfam; TIGR01972; NDH_I_M; 1.
DR   PANTHER; PTHR43507; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; 1.
DR   PANTHER; PTHR43507:SF20; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; 1.
DR   Pfam; PF01059; Oxidored_q5_N; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01437; NUOXDRDTASE4.
PE   3: Inferred from homology;
KW   Electron transport {ECO:0000256|RuleBase:RU003297};
KW   Membrane {ECO:0000256|RuleBase:RU003297};
KW   Mitochondrion {ECO:0000256|RuleBase:RU003297, ECO:0000313|EMBL:QJS52082.1};
KW   NAD {ECO:0000256|RuleBase:RU003297};
KW   Respiratory chain {ECO:0000256|RuleBase:RU003297};
KW   Transmembrane {ECO:0000256|RuleBase:RU003297};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU003297}; Transport {ECO:0000256|RuleBase:RU003297};
KW   Ubiquinone {ECO:0000256|RuleBase:RU003297}.
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        61..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        94..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        118..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        149..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        190..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        220..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        253..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        282..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        306..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        348..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   DOMAIN          1..109
FT                   /note="NADH:ubiquinone oxidoreductase chain 4 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01059"
FT   DOMAIN          112..398
FT                   /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT                   subunit"
FT                   /evidence="ECO:0000259|Pfam:PF00361"
SQ   SEQUENCE   451 AA;  50829 MW;  386B3A352482534E CRC64;
     MLKIIIPTMM LMPSSMLLKP KILYQTMISY TFLLALMSLM LLKQDTYLKP MSNLYFNLDP
     ISAPLLTLSF WLLPLMIIAS QHMMLSEPMQ RQRMFLTTIT LLQALISLTF LASNLTTMYI
     MFEATLVPTL IVITRWGQQA ERLTAGSYFI MYTLMTSMPL LMSIIFLNNT SHTPTLFFMM
     TQPTNQWTNL LLWLACLTAF LAKLPVYGLH LWLPKAHVEA PIAGSMVLAA ILLKLGGYGI
     IRMMQIFPVT KTDMFLPFMV LSLWGAILAN MTCLQQTDLK SLIAYSSISH MGLVIAAIMI
     QTPWALAGAM ALMIAHGFTS SALFCLANIT YERTHTRIMV LTRGFHNILP MMTAWWLLAN
     LTNIAIPPSM NFTGELLIMS SMFNWCPTTM ILLGLSMLIT ATYSLHMFLS TQAGKPSPDL
     NINPTHTREH LLLILHIAPL LLISMKPELV L
//