ID A0A6M2VCF7_9MONO Unreviewed; 81 AA. AC A0A6M2VCF7; DT 07-OCT-2020, integrated into UniProtKB/TrEMBL. DT 07-OCT-2020, sequence version 1. DT 24-JAN-2024, entry version 13. DE RecName: Full=Hemagglutinin glycoprotein {ECO:0000256|ARBA:ARBA00020483}; DE Flags: Fragment; OS Measles virus genotype B3. OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; OC Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae; OC Morbillivirus; Morbillivirus hominis; Measles morbillivirus. OX NCBI_TaxID=658048 {ECO:0000313|EMBL:QCX20505.1}; RN [1] {ECO:0000313|EMBL:QCX20505.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MVs/Marseille.FRA/19.2019/3217[B3] RC {ECO:0000313|EMBL:QCX20505.1}; RA Colson P., La Scola B.; RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Attaches the virus to cell receptors and thereby initiating CC infection. Binding of H protein to the receptor induces a CC conformational change that allows the F protein to trigger virion/cell CC membranes fusion. May use human CD46 and/or SLAMF1 as receptors for CC viral entry into the cell. The high degree of interaction between H and CC MCP/CD46 results in down-regulation of the latter from the surface of CC infected cells, rendering them more sensitive to c3b-mediated CC complement lysis. {ECO:0000256|ARBA:ARBA00037156}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single- CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}. Virion CC membrane {ECO:0000256|ARBA:ARBA00004208}; Single-pass type II membrane CC protein {ECO:0000256|ARBA:ARBA00004208}. CC -!- SIMILARITY: Belongs to the paramyxoviruses hemagglutinin-neuraminidase CC family. Non-sialidase subfamily. {ECO:0000256|ARBA:ARBA00006578}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MN005226; QCX20505.1; -; Genomic_RNA. DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro. DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR Gene3D; 2.120.10.10; -; 1. DR InterPro; IPR000665; Hemagglutn/HN. DR InterPro; IPR036278; Sialidase_sf. DR Pfam; PF00423; HN; 1. DR SUPFAM; SSF50939; Sialidases; 1. PE 3: Inferred from homology; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Hemagglutinin {ECO:0000256|ARBA:ARBA00022546, KW ECO:0000256|RuleBase:RU004216}; KW Host membrane {ECO:0000256|ARBA:ARBA00022870}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}; KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804}; KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879, KW ECO:0000256|RuleBase:RU004216}; KW Virion {ECO:0000256|ARBA:ARBA00022879, ECO:0000256|RuleBase:RU004216}; KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}. FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:QCX20505.1" FT NON_TER 81 FT /evidence="ECO:0000313|EMBL:QCX20505.1" SQ SEQUENCE 81 AA; 9123 MW; 5DDC223353A9B5E1 CRC64; VPLSTDDPVV DRLYLSSHRG VIADNQAKWA VPTTRTDDKL RMETCFQHAC KGKIQALCEN PEWVPLKDNR IPSYGVLSVD L //