ID A0A6L7GTW8_9ACTN Unreviewed; 291 AA. AC A0A6L7GTW8; DT 07-OCT-2020, integrated into UniProtKB/TrEMBL. DT 07-OCT-2020, sequence version 1. DT 13-SEP-2023, entry version 11. DE SubName: Full=NAD-dependent deacetylase {ECO:0000313|EMBL:MXP22521.1}; GN ORFNames=GIY30_14335 {ECO:0000313|EMBL:MXP22521.1}; OS Gordonia mangrovi. OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae; OC Gordonia. OX NCBI_TaxID=2665643 {ECO:0000313|EMBL:MXP22521.1, ECO:0000313|Proteomes:UP000475545}; RN [1] {ECO:0000313|EMBL:MXP22521.1, ECO:0000313|Proteomes:UP000475545} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HNM0687 {ECO:0000313|EMBL:MXP22521.1, RC ECO:0000313|Proteomes:UP000475545}; RA Huang X., Xie Y., Chu X., Xiao K.; RT "Gordonia sp. nov., a novel actinobacterium isolated from mangrove soil in RT Hainan."; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:MXP22521.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; WMBR01000003; MXP22521.1; -; Genomic_DNA. DR AlphaFoldDB; A0A6L7GTW8; -. DR Proteomes; UP000475545; Unassembled WGS sequence. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro. DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW. DR Gene3D; 3.30.1600.10; SIR2/SIRT2 'Small Domain; 1. DR Gene3D; 3.40.50.1220; TPP-binding domain; 1. DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom. DR InterPro; IPR003000; Sirtuin. DR InterPro; IPR026591; Sirtuin_cat_small_dom_sf. DR InterPro; IPR026590; Ssirtuin_cat_dom. DR PANTHER; PTHR47651; NAD-DEPENDENT HISTONE DEACETYLASE HST4; 1. DR PANTHER; PTHR47651:SF7; NAD-DEPENDENT PROTEIN DEACYLASE SIR-2.2; 1. DR Pfam; PF02146; SIR2; 1. DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1. DR PROSITE; PS50305; SIRTUIN; 1. PE 4: Predicted; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00236}; KW NAD {ECO:0000256|ARBA:ARBA00023027}; KW Reference proteome {ECO:0000313|Proteomes:UP000475545}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00236}. FT DOMAIN 15..291 FT /note="Deacetylase sirtuin-type" FT /evidence="ECO:0000259|PROSITE:PS50305" FT ACT_SITE 136 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" FT BINDING 144 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" FT BINDING 147 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" FT BINDING 198 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" FT BINDING 201 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" SQ SEQUENCE 291 AA; 32060 MW; A34DAEE70747972D CRC64; MRTRLQIGWT PAEPTPLDEA VDDQIRRARA LLEGCRIVAL TGAGISTDSG IPDYRSPGAP TRTPMTLEMF LSSPEFRRHY WARNHLGWRH MDGAEPNIAH RALTDLQRQG RLTGVITQNV DMLHTKAGTR RVLELHGCYG RVRCLGCDWL ISRHRLAEHL EGLNDRFSER VRGRGAIEVA PDADAAVDDT SDFTMIDCPN CGGIVKPDIV YFGESVPKPT VEQAFSMLDD ADALLVVGSS LTVMSGLRFA RHAHRTGKRL VIVNRGATRA DDLADLKIDH LASVVLPALA A //