ID A0A6J0YZ89_ODOVR Unreviewed; 592 AA. AC A0A6J0YZ89; DT 07-OCT-2020, integrated into UniProtKB/TrEMBL. DT 07-OCT-2020, sequence version 1. DT 24-JAN-2024, entry version 13. DE RecName: Full=Transcription factor 4 {ECO:0000256|ARBA:ARBA00040305}; GN Name=TCF4 {ECO:0000313|RefSeq:XP_020766315.1, GN ECO:0000313|RefSeq:XP_020766316.1}; OS Odocoileus virginianus texanus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Cervidae; OC Odocoileinae; Odocoileus. OX NCBI_TaxID=9880 {ECO:0000313|Proteomes:UP000504613, ECO:0000313|RefSeq:XP_020766316.1}; RN [1] {ECO:0000313|RefSeq:XP_020766315.1, ECO:0000313|RefSeq:XP_020766316.1} RP IDENTIFICATION. RC TISSUE=Blood {ECO:0000313|RefSeq:XP_020766315.1, RC ECO:0000313|RefSeq:XP_020766316.1}; RG RefSeq; RL Submitted (SEP-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_020766315.1; XM_020910656.1. DR RefSeq; XP_020766316.1; XM_020910657.1. DR Proteomes; UP000504613; Unplaced. DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro. DR CDD; cd18945; bHLH_E-protein_TCF4_E2-2; 1. DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1. DR InterPro; IPR011598; bHLH_dom. DR InterPro; IPR036638; HLH_DNA-bd_sf. DR PANTHER; PTHR11793; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR; 1. DR PANTHER; PTHR11793:SF10; TRANSCRIPTION FACTOR 4; 1. DR Pfam; PF00010; HLH; 1. DR SMART; SM00353; HLH; 1. DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1. DR PROSITE; PS50888; BHLH; 1. PE 4: Predicted; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000504613}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}. FT DOMAIN 489..542 FT /note="BHLH" FT /evidence="ECO:0000259|PROSITE:PS50888" FT REGION 1..166 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 202..242 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 257..300 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 390..495 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 559..592 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..45 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 60..80 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 105..166 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 202..240 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 390..409 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 434..495 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 592 AA; 63351 MW; B0C6E9179E7787E0 CRC64; MTSRDLGSHD NLSPPFVNSR IQSKTERGSY PSYGRESNLQ GCHQQSLLGG DMDMGNPGTL SPTKPGSQYY QYSSNNPRRR PLHGSALEVQ TKKVRKVPPG LPSSVYAPSA STADYNRDSP GYPSSKPAAS TFPSSFFMQD GHHSSDPWSS SSGMNQPGYG GMLGNSSHIP QSSSYCSLHP HERLGYPSHS SADINSSLPP MSTFHRSGTN HYSTSSCTPP ANGTDSIMAN RGSGAAGSSQ TGDALGKALA SIYSPDHTNN SFSSNPSTPV GSPPSLSAGT AVWSRNGGQA SSSPNYEGPL HSLQSRIEDR LERLDDAIHV LRNHAVGPST AMPGGHGDMH GIIGPSHNGA MGGLASGYGT GLLSANRHSL MVGAHREDGV ALRGSHSLVP NQVPVPQLPV QSATSPDLNP PQDPYRGMPP GLQGQSVSSG SSEIKSDDEG DENLQDTKSS EDKKLDDDKK DIKSITRSRS SNNDDEDLTP EQKAEREKER RMANNARERL RVRDINEAFK ELGRMVQLHL KSDKPQTKLL ILHQAVAVIL SLEQQVRERN LNPKAACLKR REEEKVSSEP PPLSLAGPHP GMGDASNHMG QM //