ID A0A6J0TI15_9SAUR Unreviewed; 722 AA. AC A0A6J0TI15; DT 07-OCT-2020, integrated into UniProtKB/TrEMBL. DT 07-OCT-2020, sequence version 1. DT 25-MAY-2022, entry version 5. DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365}; DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728}; GN Name=MPEG1 {ECO:0000313|RefSeq:XP_020647947.1}; OS Pogona vitticeps (central bearded dragon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; OC Iguania; Acrodonta; Agamidae; Amphibolurinae; Pogona. OX NCBI_TaxID=103695 {ECO:0000313|Proteomes:UP000504619, ECO:0000313|RefSeq:XP_020647947.1}; RN [1] {ECO:0000313|RefSeq:XP_020647947.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (FEB-2021) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane CC {ECO:0000256|ARBA:ARBA00004358}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004358}. Membrane CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the MPEG1 family. CC {ECO:0000256|ARBA:ARBA00007256}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_020647947.1; XM_020792288.1. DR Proteomes; UP000504619; Unplaced. DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR InterPro; IPR020864; MACPF. DR InterPro; IPR039707; MPEG1. DR PANTHER; PTHR31463; PTHR31463; 1. DR Pfam; PF01823; MACPF; 1. DR SMART; SM00457; MACPF; 1. DR PROSITE; PS51412; MACPF_2; 1. PE 3: Inferred from homology; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000504619}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 20..722 FT /note="Macrophage-expressed gene 1 protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5027016696" FT TRANSMEM 656..678 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 31..345 FT /note="MACPF" FT /evidence="ECO:0000259|PROSITE:PS51412" FT REGION 701..722 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 708..722 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 722 AA; 80214 MW; DA546023CB1FD43E CRC64; MSKFSIFFSL ALIFGVGWAM DQPARHPPFI GLQGCMQALK LPVLEVLPGG GWDNLRNVDM GRVINLNYSL CKTTEDGSYI IPNEVFSIAL KHSFLEMNSE IIDSWMDYQC ITAASINLEL SYLNINGRFS SDFRRMKTHQ VREQAVTTRV QVRNLVYTVK FDPAATLDEG FQQQLFTIAG HLENNQTRMA DYLAEVLVLN YGTHVITDVD AGASLVQEDQ IKSTFVKDSQ SMRSSITAAA GVSFHNTINF NAGFSVGTED LFTKQYLANR TNSRVESIGG FPFYPGITLK AWQESITNHL VAIDRSGLPL QFFITPKNLP GLPHLIVKKL ARTVASAISR YYSFNTYPGC TDPASPNFNF YANTDDGTCE GTMTNFTFGG AYQKCAQLEG PDAAILCQGL EQKNPLTGAF SCPAGYTPIR LSSQQREEGY SHLDCHRDCF VWKLFCKLVC KDVFTLSKVQ FSSYWCAARG TVPENSGFLF GGLFTTKSTN PMTNAQSCPS RYFQMKLFDQ LKICVSRDVR GQRYSVPFGG FFSCQVGNPL VGSHNGTDND PYPKRCPVGF SQHLALISDG CQVEYCVQAG RFTEGSLPQA RLPPFTHKPV MSFVATDTVM VINSNDGQMW VKDSQTQLWK IGNPAEVPHN MKKGKYVGGN LSTGEAAGIT ISVTIGLAIL IGLSVYGCRR YKTKEYREIE EEEKSLILNH PAHSHQNEME DAPQQIQENQ TV //