ID A0A6I9K585_CHRAS Unreviewed; 117 AA. AC A0A6I9K585; DT 07-OCT-2020, integrated into UniProtKB/TrEMBL. DT 07-OCT-2020, sequence version 1. DT 07-APR-2021, entry version 4. DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113}; GN Name=INSIG2 {ECO:0000313|RefSeq:XP_006868783.1}; OS Chrysochloris asiatica (Cape golden mole). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Afrotheria; Chrysochloridae; Chrysochlorinae; Chrysochloris. OX NCBI_TaxID=185453 {ECO:0000313|Proteomes:UP000504623, ECO:0000313|RefSeq:XP_006868783.1}; RN [1] {ECO:0000313|RefSeq:XP_006868783.1} RP IDENTIFICATION. RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_006868783.1}; RG RefSeq; RL Submitted (OCT-2020) to UniProtKB. CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis. CC {ECO:0000256|RuleBase:RU241113}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004477}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the INSIG family. CC {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|RuleBase:RU241113}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_006868783.1; XM_006868721.1. DR GeneID; 102842387; -. DR CTD; 51141; -. DR Proteomes; UP000504623; Genome assembly. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR025929; INSIG_fam. DR PANTHER; PTHR15301; PTHR15301; 1. DR Pfam; PF07281; INSIG; 1. PE 3: Inferred from homology; KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548, KW ECO:0000256|RuleBase:RU241113}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824}; KW Lipid metabolism {ECO:0000256|RuleBase:RU241113}; KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113}; KW Reference proteome {ECO:0000313|Proteomes:UP000504623}; KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221, KW ECO:0000256|RuleBase:RU241113}; KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU241113}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 25..40 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 47..66 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 78..98 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" SQ SEQUENCE 117 AA; 12957 MW; B6E21586B3026476 CRC64; MRCVAVFVGI NHASAKVDFD NNIQLSLTLA ALSIGLWWTF DRSRSGFGLG VGIAFLATLV TQLLVYNGVY QYTSPDFLYV RSWLPCIFFA GGITMGNIGR QLALYECKVI AEKSHQE //