ID   A0A6I5DBI8_9ACTN        Unreviewed;       523 AA.
AC   A0A6I5DBI8;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   24-JUL-2024, entry version 12.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   ORFNames=GTW73_27775 {ECO:0000313|EMBL:MYS17720.1};
OS   Streptomyces sp. SID4982.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2690291 {ECO:0000313|EMBL:MYS17720.1, ECO:0000313|Proteomes:UP000449013};
RN   [1] {ECO:0000313|EMBL:MYS17720.1, ECO:0000313|Proteomes:UP000449013}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SID4982 {ECO:0000313|EMBL:MYS17720.1,
RC   ECO:0000313|Proteomes:UP000449013};
RX   PubMed=30705269; DOI=.1038/s41467-019-08438-0;
RA   Chevrette M.G., Carlson C.M., Ortega H.E., Thomas C., Ananiev G.E.,
RA   Barns K.J., Book A.J., Cagnazzo J., Carlos C., Flanigan W., Grubbs K.J.,
RA   Horn H.A., Hoffmann F.M., Klassen J.L., Knack J.J., Lewin G.R.,
RA   McDonald B.R., Muller L., Melo W.G.P., Pinto-Tomas A.A., Schmitz A.,
RA   Wendt-Pienkowski E., Wildman S., Zhao M., Zhang F., Bugni T.S., Andes D.R.,
RA   Pupo M.T., Currie C.R.;
RT   "The antimicrobial potential of Streptomyces from insect microbiomes.";
RL   Nat. Commun. 10:516-516(2019).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:MYS17720.1}.
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DR   EMBL; WWIS01000908; MYS17720.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A6I5DBI8; -.
DR   Proteomes; UP000449013; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR050428; TCS_sensor_his_kinase.
DR   PANTHER; PTHR45436:SF5; SENSOR HISTIDINE KINASE TRCS; 1.
DR   PANTHER; PTHR45436; SENSOR HISTIDINE KINASE YKOH; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000313|EMBL:MYS17720.1};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000313|EMBL:MYS17720.1};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   DOMAIN          242..350
FT                   /note="Histidine kinase/HSP90-like ATPase"
FT                   /evidence="ECO:0000259|Pfam:PF02518"
FT   REGION          373..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          435..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          490..523
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..472
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   523 AA;  56998 MW;  CAEE22D1EF492A84 CRC64;
     MMAAVTAAAV FLVPGAARTA VGCCGVVATL LVLATAAEVV RRGRQLRAVQ AEHARHTAYL
     EHRIAAHDAE IVRLGSEVLP HALARLRRGE RLRDVLRNVV DDDPELRHLP PSQRELLRIA
     LRGAEHEINM RDATQRAFVT TARRVQAIVH QQAKELREME EDHGRNAEVF DDLLRVDHGT
     ALIGRLADSI SVLGGGRPGR QWPVPVSLYS VLRGAMSRIL EFPRINLASI VNINIKGTSV
     EPIIHAAAEL FDNATRYSPP STKVHVTAFE VQTGLAIEIE DAGVSLSEEG RARVEQMILD
     ARADDDAHNL GDSPRLGLAV VGRLCNAFNM DVSLRASAYG GVRAILVVPR DMTTTEPGVG
     AAHGIGATAV PMPELGALEG PKRPPKRRRP TAPRVPAPAS MEDDVPEVTE WTANGLPQRR
     SRVTVPLSQR YAEQAAIEQA EREGRPTIWS RPEAGPDPRA ETDPERQKLL DREPGMWVDA
     FWDGMKKGNE GAHPTDFTRN PTAYLHLIDD SADTGAGDEG EPK
//